DISC: Latent Diffusion Models with Self-Distillation from Separated Conditions for Prostate Cancer Grading

Latent Diffusion Models (LDMs) can generate high-fidelity images from noise, offering a promising approach for augmenting histopathology images for training cancer grading models. While previous works successfully generated high-fidelity histopathology images using LDMs, the generation of image tiles to improve prostate cancer grading has not yet been explored. Additionally, LDMs face challenges in accurately generating admixtures of multiple cancer grades in a tile when conditioned by a tile mask. In this study, we train specific LDMs to generate synthetic tiles that contain multiple Gleason Grades (GGs) by leveraging pixel-wise annotations in input tiles. We introduce a novel framework named Self-Distillation from Separated Conditions (DISC) that generates GG patterns guided by GG masks. Finally, we deploy a training framework for pixel-level and slide-level prostate cancer grading, where synthetic tiles are effectively utilized to improve the cancer grading performance of existing models. As a result, this work surpasses previous works in two domains: 1) our LDMs enhanced with DISC produce more accurate tiles in terms of GG patterns, and 2) our training scheme, incorporating synthetic data, significantly improves the generalization of the baseline model for prostate cancer grading, particularly in challenging cases of rare GG5, demonstrating the potential of generative models to enhance cancer grading when data is limited.

Peer-aided Repairer: Empowering Large Language Models to Repair Advanced Student Assignments

Automated generation of feedback on programming assignments holds significant benefits for programming education, especially when it comes to advanced assignments. Automated Program Repair techniques, especially Large Language Model based approaches, have gained notable recognition for their potential to fix introductory assignments. However, the programs used for evaluation are relatively simple. It remains unclear how existing approaches perform in repairing programs from higher-level programming courses. To address these limitations, we curate a new advanced student assignment dataset named Defects4DS from a higher-level programming course. Subsequently, we identify the challenges related to fixing bugs in advanced assignments. Based on the analysis, we develop a framework called PaR that is powered by the LLM. PaR works in three phases: Peer Solution Selection, Multi-Source Prompt Generation, and Program Repair. Peer Solution Selection identifies the closely related peer programs based on lexical, semantic, and syntactic criteria. Then Multi-Source Prompt Generation adeptly combines multiple sources of information to create a comprehensive and informative prompt for the last Program Repair stage. The evaluation on Defects4DS and another well-investigated ITSP dataset reveals that PaR achieves a new state-of-the-art performance, demonstrating impressive improvements of 19.94% and 15.2% in repair rate compared to prior state-of-the-art LLM- and symbolic-based approaches, respectively

Large Language Models as Master Key: Unlocking the Secrets of Materials Science with GPT

The amount of data has growing significance in exploring cutting-edge materials and a number of datasets have been generated either by hand or automated approaches. However, the materials science field struggles to effectively utilize the abundance of data, especially in applied disciplines where materials are evaluated based on device performance rather than their properties. This article presents a new natural language processing (NLP) task called structured information inference (SII) to address the complexities of information extraction at the device level in materials science. We accomplished this task by tuning GPT-3 on an existing perovskite solar cell FAIR (Findable, Accessible, Interoperable, Reusable) dataset with 91.8% F1-score and extended the dataset with data published since its release. The produced data is formatted and normalized, enabling its direct utilization as input in subsequent data analysis. This feature empowers materials scientists to develop models by selecting high-quality review articles within their domain. Additionally, we designed experiments to predict the electrical performance of solar cells and design materials or devices with targeted parameters using large language models (LLMs). Our results demonstrate comparable performance to traditional machine learning methods without feature selection, highlighting the potential of LLMs to acquire scientific knowledge and design new materials akin to materials scientists.