DETRAM: End-to-end DEtection, Tracking and Recovery of HumAn Meshes

In the task of human mesh recovery (HMR), multi-person scenes are particularly difficult to handle due to the many entities that appear and occlusions between them over time. In particular for video inputs, there is a need to track each entity reliably and consistently. Existing methods rely on pretrained human detection modules, increasing their runtime and limiting the number of tracked entities. We present DETRAM, a unified framework for multi-person HMR and tracking that simultaneously detects, reconstructs, and tracks humans across time, both automatically and via user prompts. DETRAM uses a single transformer decoder with an identity-consistent set of learnable query embeddings that persist across frames: detection queries discover new people, tracking queries maintain pose and shape for existing individuals, and prompt queries follow user-specified identities. Our approach achieves state-of-the-art tracking results on PoseTrack21, 3DPW, BEDLAM, and MuPoTS-3D, and competitive reconstruction accuracy on BEDLAM and 3DPW, while uniquely supporting prompt-based tracking of individuals in multi-person scenes. To our knowledge, this is the first method to unify promptability and multi-person HMR with tracking in an end-to-end trainable framework, enabling user-directed human analysis in videos.

DyaPlex: Full-Duplex Speech-Motion Model for Dyadic Interaction

We present DyaPlex, a streaming, full-duplex speech-and-motion model designed for dyadic interaction. To capture the continuous and reciprocal nature of human communication, this full-duplex capability empowers the agent to simultaneously perceive and generate both speech and physical motion in a streaming fashion. At its core, our method leverages the strong priors of a foundational full-duplex speech model and integrates a novel motion pathway, thereby achieving fully synchronized multi-modal interaction. Specifically, we design a dual-tower Transformer architecture that preserves the zero-shot conversational reasoning of a frozen base speech model while constructing a deeply coupled, streaming motion pathway. By introducing a unified dyadic token interleaving mechanism and guiding cross-attention via a time-aligned speech-motion RoPE, our model effectively aligns autoregressive motions with rich latent speech features. Trained on the 4,000-hour Seamless Interaction dataset, our model effectively captures cross-speaker dependencies and establishes new state-of-the-art performance across both monadic and dyadic human interaction benchmarks.

VideoFDB: Evaluating Full-Duplex Vision-Speech Capabilities in Conversational Agents

Natural human conversation is full-duplex and audio-visual: people simultaneously speak and listen while continuously interpreting and producing nonverbal cues, such as nods, smiles, and gestures. To support successful human-agent interaction, agents must model full-duplex audiovisual conversation; however, existing full-duplex benchmarks evaluate only speech. In this work, we present VideoFDB, the first benchmark to evaluate full-duplex audio-visual-to-audio-visual (AV2AV) conversational agents. VideoFDB contributes (i) 237 dyadic clips spanning 11 nonverbal conversational dynamics from real-world video calls, (ii) a taxonomy separating perception from generation behaviors, and (iii) a rubric-based LM-as-judge evaluation framework with interpretable axes for assessing conversational quality with respect to nonverbal conversational dynamics. Across open- and closed-source vision-speech agents, we find systematic failure modes: captioning collapse and visual-stream ignorance, and we show that current systems exploit vision for explicit visual question answering but not for the streaming joint audiovisual grounding required in natural conversation. We further evaluate cascaded speech-to-avatar systems and find that their architecture fundamentally precludes the production of full-duplex nonverbal cues. As the first benchmark for full-duplex AV2AV interaction, VideoFDB establishes a foundation for systematic evaluation and, we hope, will accelerate the advancement and development of next-generation multimodal conversational agents.

Instant Expressive Gaussian Head Avatar via 3D-Aware Expression Distillation

Portrait animation has witnessed tremendous quality improvements thanks to recent advances in video diffusion models. However, these 2D methods often compromise 3D consistency and speed, limiting their applicability in real-world scenarios, such as digital twins or telepresence. In contrast, 3D-aware facial animation feedforward methods -- built upon explicit 3D representations, such as neural radiance fields or Gaussian splatting -- ensure 3D consistency and achieve faster inference speed, but come with inferior expression details. In this paper, we aim to combine their strengths by distilling knowledge from a 2D diffusion-based method into a feed-forward encoder, which instantly converts an in-the-wild single image into a 3D-consistent, fast yet expressive animatable representation. Our animation representation is decoupled from the face's 3D representation and learns motion implicitly from data, eliminating the dependency on pre-defined parametric models that often constrain animation capabilities. Unlike previous computationally intensive global fusion mechanisms (e.g., multiple attention layers) for fusing 3D structural and animation information, our design employs an efficient lightweight local fusion strategy to achieve high animation expressivity. As a result, our method runs at 107.31 FPS for animation and pose control while achieving comparable animation quality to the state-of-the-art, surpassing alternative designs that trade speed for quality or vice versa. Project website is https://research.nvidia.com/labs/amri/projects/instant4d

Generalizing AI-driven Assessment of Immunohistochemistry across Immunostains and Cancer Types: A Universal Immunohistochemistry Analyzer

Despite advancements in methodologies, immunohistochemistry (IHC) remains the most utilized ancillary test for histopathologic and companion diagnostics in targeted therapies. However, objective IHC assessment poses challenges. Artificial intelligence (AI) has emerged as a potential solution, yet its development requires extensive training for each cancer and IHC type, limiting versatility. We developed a Universal IHC (UIHC) analyzer, an AI model for interpreting IHC images regardless of tumor or IHC types, using training datasets from various cancers stained for PD-L1 and/or HER2. This multi-cohort trained model outperforms conventional single-cohort models in interpreting unseen IHCs (Kappa score 0.578 vs. up to 0.509) and consistently shows superior performance across different positive staining cutoff values. Qualitative analysis reveals that UIHC effectively clusters patches based on expression levels. The UIHC model also quantitatively assesses c-MET expression with MET mutations, representing a significant advancement in AI application in the era of personalized medicine and accumulating novel biomarkers.

EFE: End-to-end Frame-to-Gaze Estimation

Despite the recent development of learning-based gaze estimation methods, most methods require one or more eye or face region crops as inputs and produce a gaze direction vector as output. Cropping results in a higher resolution in the eye regions and having fewer confounding factors (such as clothing and hair) is believed to benefit the final model performance. However, this eye/face patch cropping process is expensive, erroneous, and implementation-specific for different methods. In this paper, we propose a frame-to-gaze network that directly predicts both 3D gaze origin and 3D gaze direction from the raw frame out of the camera without any face or eye cropping. Our method demonstrates that direct gaze regression from the raw downscaled frame, from FHD/HD to VGA/HVGA resolution, is possible despite the challenges of having very few pixels in the eye region. The proposed method achieves comparable results to state-of-the-art methods in Point-of-Gaze (PoG) estimation on three public gaze datasets: GazeCapture, MPIIFaceGaze, and EVE, and generalizes well to extreme camera view changes.

OCELOT: Overlapped Cell on Tissue Dataset for Histopathology

Cell detection is a fundamental task in computational pathology that can be used for extracting high-level medical information from whole-slide images. For accurate cell detection, pathologists often zoom out to understand the tissue-level structures and zoom in to classify cells based on their morphology and the surrounding context. However, there is a lack of efforts to reflect such behaviors by pathologists in the cell detection models, mainly due to the lack of datasets containing both cell and tissue annotations with overlapping regions. To overcome this limitation, we propose and publicly release OCELOT, a dataset purposely dedicated to the study of cell-tissue relationships for cell detection in histopathology. OCELOT provides overlapping cell and tissue annotations on images acquired from multiple organs. Within this setting, we also propose multi-task learning approaches that benefit from learning both cell and tissue tasks simultaneously. When compared against a model trained only for the cell detection task, our proposed approaches improve cell detection performance on 3 datasets: proposed OCELOT, public TIGER, and internal CARP datasets. On the OCELOT test set in particular, we show up to 6.79 improvement in F1-score. We believe the contributions of this paper, including the release of the OCELOT dataset at https://lunit-io.github.io/research/publications/ocelot are a crucial starting point toward the important research direction of incorporating cell-tissue relationships in computation pathology.

Benchmarking Self-Supervised Learning on Diverse Pathology Datasets

Computational pathology can lead to saving human lives, but models are annotation hungry and pathology images are notoriously expensive to annotate. Self-supervised learning has shown to be an effective method for utilizing unlabeled data, and its application to pathology could greatly benefit its downstream tasks. Yet, there are no principled studies that compare SSL methods and discuss how to adapt them for pathology. To address this need, we execute the largest-scale study of SSL pre-training on pathology image data, to date. Our study is conducted using 4 representative SSL methods on diverse downstream tasks. We establish that large-scale domain-aligned pre-training in pathology consistently out-performs ImageNet pre-training in standard SSL settings such as linear and fine-tuning evaluations, as well as in low-label regimes. Moreover, we propose a set of domain-specific techniques that we experimentally show leads to a performance boost. Lastly, for the first time, we apply SSL to the challenging task of nuclei instance segmentation and show large and consistent performance improvements under diverse settings.

Interactive Multi-Class Tiny-Object Detection

Annotating tens or hundreds of tiny objects in a given image is laborious yet crucial for a multitude of Computer Vision tasks. Such imagery typically contains objects from various categories, yet the multi-class interactive annotation setting for the detection task has thus far been unexplored. To address these needs, we propose a novel interactive annotation method for multiple instances of tiny objects from multiple classes, based on a few point-based user inputs. Our approach, C3Det, relates the full image context with annotator inputs in a local and global manner via late-fusion and feature-correlation, respectively. We perform experiments on the Tiny-DOTA and LCell datasets using both two-stage and one-stage object detection architectures to verify the efficacy of our approach. Our approach outperforms existing approaches in interactive annotation, achieving higher mAP with fewer clicks. Furthermore, we validate the annotation efficiency of our approach in a user study where it is shown to be 2.85x faster and yield only 0.36x task load (NASA-TLX, lower is better) compared to manual annotation. The code is available at https://github.com/ChungYi347/Interactive-Multi-Class-Tiny-Object-Detection.

Weakly-Supervised Physically Unconstrained Gaze Estimation

A major challenge for physically unconstrained gaze estimation is acquiring training data with 3D gaze annotations for in-the-wild and outdoor scenarios. In contrast, videos of human interactions in unconstrained environments are abundantly available and can be much more easily annotated with frame-level activity labels. In this work, we tackle the previously unexplored problem of weakly-supervised gaze estimation from videos of human interactions. We leverage the insight that strong gaze-related geometric constraints exist when people perform the activity of "looking at each other" (LAEO). To acquire viable 3D gaze supervision from LAEO labels, we propose a training algorithm along with several novel loss functions especially designed for the task. With weak supervision from two large scale CMU-Panoptic and AVA-LAEO activity datasets, we show significant improvements in (a) the accuracy of semi-supervised gaze estimation and (b) cross-domain generalization on the state-of-the-art physically unconstrained in-the-wild Gaze360 gaze estimation benchmark. We open source our code at https://github.com/NVlabs/weakly-supervised-gaze.