COVID-19 Literature Knowledge Graph Construction and Drug Repurposing Report Generation

To combat COVID-19, clinicians and scientists all need to digest the vast amount of relevant biomedical knowledge in literature to understand the disease mechanism and the related biological functions. We have developed a novel and comprehensive knowledge discovery framework, COVID-KG, which leverages novel semantic representation and external ontologies to represent text and images in the input literature data, and then performs various extraction components to extract fine-grained multimedia knowledge elements (entities, relations and events). We then exploit the constructed multimedia KGs for question answering and report generation, using drug repurposing as a case study. Our framework also provides detailed contextual sentences, subfigures and knowledge subgraphs as evidence. All of the data, KGs, resources, and shared services are publicly available.

A Formal Analysis of Multimodal Referring Strategies Under Common Ground

In this paper, we present an analysis of computationally generated mixed-modality definite referring expressions using combinations of gesture and linguistic descriptions. In doing so, we expose some striking formal semantic properties of the interactions between gesture and language, conditioned on the introduction of content into the common ground between the (computational) speaker and (human) viewer, and demonstrate how these formal features can contribute to training better models to predict viewer judgment of referring expressions, and potentially to the generation of more natural and informative referring expressions.

Assessing the Efficacy of Clinical Sentiment Analysis and Topic Extraction in Psychiatric Readmission Risk Prediction

Predicting which patients are more likely to be readmitted to a hospital within 30 days after discharge is a valuable piece of information in clinical decision-making. Building a successful readmission risk classifier based on the content of Electronic Health Records (EHRs) has proved, however, to be a challenging task. Previously explored features include mainly structured information, such as sociodemographic data, comorbidity codes and physiological variables. In this paper we assess incorporating additional clinically interpretable NLP-based features such as topic extraction and clinical sentiment analysis to predict early readmission risk in psychiatry patients.

Multimodal Continuation-style Architectures for Human-Robot Interaction

We present an architecture for integrating real-time, multimodal input into a computational agent's contextual model. Using a human-avatar interaction in a virtual world, we treat aligned gesture and speech as an ensemble where content may be communicated by either modality. With a modified nondeterministic pushdown automaton architecture, the computer system: (1) consumes input incrementally using continuation-passing style until it achieves sufficient understanding the user's aim; (2) constructs and asks questions where necessary using established contextual information; and (3) maintains track of prior discourse items using multimodal cues. This type of architecture supports special cases of pushdown and finite state automata as well as integrating outputs from machine learning models. We present examples of this architecture's use in multimodal one-shot learning interactions of novel gestures and live action composition.

Distinguishing Clinical Sentiment: The Importance of Domain Adaptation in Psychiatric Patient Health Records

Recently natural language processing (NLP) tools have been developed to identify and extract salient risk indicators in electronic health records (EHRs). Sentiment analysis, although widely used in non-medical areas for improving decision making, has been studied minimally in the clinical setting. In this study, we undertook, to our knowledge, the first domain adaptation of sentiment analysis to psychiatric EHRs by defining psychiatric clinical sentiment, performing an annotation project, and evaluating multiple sentence-level sentiment machine learning (ML) models. Results indicate that off-the-shelf sentiment analysis tools fail in identifying clinically positive or negative polarity, and that the definition of clinical sentiment that we provide is learnable with relatively small amounts of training data. This project is an initial step towards further refining sentiment analysis methods for clinical use. Our long-term objective is to incorporate the results of this project as part of a machine learning model that predicts inpatient readmission risk. We hope that this work will initiate a discussion concerning domain adaptation of sentiment analysis to the clinical setting.

Situational Grounding within Multimodal Simulations

In this paper, we argue that simulation platforms enable a novel type of embodied spatial reasoning, one facilitated by a formal model of object and event semantics that renders the continuous quantitative search space of an open-world, real-time environment tractable. We provide examples for how a semantically-informed AI system can exploit the precise, numerical information provided by a game engine to perform qualitative reasoning about objects and events, facilitate learning novel concepts from data, and communicate with a human to improve its models and demonstrate its understanding. We argue that simulation environments, and game engines in particular, bring together many different notions of "simulation" and many different technologies to provide a highly-effective platform for developing both AI systems and tools to experiment in both machine and human intelligence.

Combining Deep Learning and Qualitative Spatial Reasoning to Learn Complex Structures from Sparse Examples with Noise

Many modern machine learning approaches require vast amounts of training data to learn new concepts; conversely, human learning often requires few examples--sometimes only one--from which the learner can abstract structural concepts. We present a novel approach to introducing new spatial structures to an AI agent, combining deep learning over qualitative spatial relations with various heuristic search algorithms. The agent extracts spatial relations from a sparse set of noisy examples of block-based structures, and trains convolutional and sequential models of those relation sets. To create novel examples of similar structures, the agent begins placing blocks on a virtual table, uses a CNN to predict the most similar complete example structure after each placement, an LSTM to predict the most likely set of remaining moves needed to complete it, and recommends one using heuristic search. We verify that the agent learned the concept by observing its virtual block-building activities, wherein it ranks each potential subsequent action toward building its learned concept. We empirically assess this approach with human participants' ratings of the block structures. Initial results and qualitative evaluations of structures generated by the trained agent show where it has generalized concepts from the training data, which heuristics perform best within the search space, and how we might improve learning and execution.

Multimodal Interactive Learning of Primitive Actions

We describe an ongoing project in learning to perform primitive actions from demonstrations using an interactive interface. In our previous work, we have used demonstrations captured from humans performing actions as training samples for a neural network-based trajectory model of actions to be performed by a computational agent in novel setups. We found that our original framework had some limitations that we hope to overcome by incorporating communication between the human and the computational agent, using the interaction between them to fine-tune the model learned by the machine. We propose a framework that uses multimodal human-computer interaction to teach action concepts to machines, making use of both live demonstration and communication through natural language, as two distinct teaching modalities, while requiring few training samples.

Analysis of Risk Factor Domains in Psychosis Patient Health Records

Readmission after discharge from a hospital is disruptive and costly, regardless of the reason. However, it can be particularly problematic for psychiatric patients, so predicting which patients may be readmitted is critically important but also very difficult. Clinical narratives in psychiatric electronic health records (EHRs) span a wide range of topics and vocabulary; therefore, a psychiatric readmission prediction model must begin with a robust and interpretable topic extraction component. We created a data pipeline for using document vector similarity metrics to perform topic extraction on psychiatric EHR data in service of our long-term goal of creating a readmission risk classifier. We show initial results for our topic extraction model and identify additional features we will be incorporating in the future.

Learning event representation: As sparse as possible, but not sparser

Selecting an optimal event representation is essential for event classification in real world contexts. In this paper, we investigate the application of qualitative spatial reasoning (QSR) frameworks for classification of human-object interaction in three dimensional space, in comparison with the use of quantitative feature extraction approaches for the same purpose. In particular, we modify QSRLib, a library that allows computation of Qualitative Spatial Relations and Calculi, and employ it for feature extraction, before inputting features into our neural network models. Using an experimental setup involving motion captures of human-object interaction as three dimensional inputs, we observe that the use of qualitative spatial features significantly improves the performance of our machine learning algorithm against our baseline, while quantitative features of similar kinds fail to deliver similar improvement. We also observe that sequential representations of QSR features yield the best classification performance. A result of our learning method is a simple approach to the qualitative representation of 3D activities as compositions of 2D actions that can be visualized and learned using 2-dimensional QSR.