FAN-Net: Fourier-Based Adaptive Normalization For Cross-Domain Stroke Lesion Segmentation

Since stroke is the main cause of various cerebrovascular diseases, deep learning-based stroke lesion segmentation on magnetic resonance (MR) images has attracted considerable attention. However, the existing methods often neglect the domain shift among MR images collected from different sites, which has limited performance improvement. To address this problem, we intend to change style information without affecting high-level semantics via adaptively changing the low-frequency amplitude components of the Fourier transform so as to enhance model robustness to varying domains. Thus, we propose a novel FAN-Net, a U-Net--based segmentation network incorporated with a Fourier-based adaptive normalization (FAN) and a domain classifier with a gradient reversal layer. The FAN module is tailored for learning adaptive affine parameters for the amplitude components of different domains, which can dynamically normalize the style information of source images. Then, the domain classifier provides domain-agnostic knowledge to endow FAN with strong domain generalizability. The experimental results on the ATLAS dataset, which consists of MR images from 9 sites, show the superior performance of the proposed FAN-Net compared with baseline methods.

CLIP-Lung: Textual Knowledge-Guided Lung Nodule Malignancy Prediction

Lung nodule malignancy prediction has been enhanced by advanced deep-learning techniques and effective tricks. Nevertheless, current methods are mainly trained with cross-entropy loss using one-hot categorical labels, which results in difficulty in distinguishing those nodules with closer progression labels. Interestingly, we observe that clinical text information annotated by radiologists provides us with discriminative knowledge to identify challenging samples. Drawing on the capability of the contrastive language-image pre-training (CLIP) model to learn generalized visual representations from text annotations, in this paper, we propose CLIP-Lung, a textual knowledge-guided framework for lung nodule malignancy prediction. First, CLIP-Lung introduces both class and attribute annotations into the training of the lung nodule classifier without any additional overheads in inference. Second, we designed a channel-wise conditional prompt (CCP) module to establish consistent relationships between learnable context prompts and specific feature maps. Third, we align image features with both class and attribute features via contrastive learning, rectifying false positives and false negatives in latent space. The experimental results on the benchmark LIDC-IDRI dataset have demonstrated the superiority of CLIP-Lung, both in classification performance and interpretability of attention maps.

BerDiff: Conditional Bernoulli Diffusion Model for Medical Image Segmentation

Medical image segmentation is a challenging task with inherent ambiguity and high uncertainty, attributed to factors such as unclear tumor boundaries and multiple plausible annotations. The accuracy and diversity of segmentation masks are both crucial for providing valuable references to radiologists in clinical practice. While existing diffusion models have shown strong capacities in various visual generation tasks, it is still challenging to deal with discrete masks in segmentation. To achieve accurate and diverse medical image segmentation masks, we propose a novel conditional Bernoulli Diffusion model for medical image segmentation (BerDiff). Instead of using the Gaussian noise, we first propose to use the Bernoulli noise as the diffusion kernel to enhance the capacity of the diffusion model for binary segmentation tasks, resulting in more accurate segmentation masks. Second, by leveraging the stochastic nature of the diffusion model, our BerDiff randomly samples the initial Bernoulli noise and intermediate latent variables multiple times to produce a range of diverse segmentation masks, which can highlight salient regions of interest that can serve as valuable references for radiologists. In addition, our BerDiff can efficiently sample sub-sequences from the overall trajectory of the reverse diffusion, thereby speeding up the segmentation process. Extensive experimental results on two medical image segmentation datasets with different modalities demonstrate that our BerDiff outperforms other recently published state-of-the-art methods. Our results suggest diffusion models could serve as a strong backbone for medical image segmentation.

CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization

Low-dose computed tomography (CT) images suffer from noise and artifacts due to photon starvation and electronic noise. Recently, some works have attempted to use diffusion models to address the over-smoothness and training instability encountered by previous deep-learning-based denoising models. However, diffusion models suffer from long inference times due to the large number of sampling steps involved. Very recently, cold diffusion model generalizes classical diffusion models and has greater flexibility. Inspired by the cold diffusion, this paper presents a novel COntextual eRror-modulated gEneralized Diffusion model for low-dose CT (LDCT) denoising, termed CoreDiff. First, CoreDiff utilizes LDCT images to displace the random Gaussian noise and employs a novel mean-preserving degradation operator to mimic the physical process of CT degradation, significantly reducing sampling steps thanks to the informative LDCT images as the starting point of the sampling process. Second, to alleviate the error accumulation problem caused by the imperfect restoration operator in the sampling process, we propose a novel ContextuaL Error-modulAted Restoration Network (CLEAR-Net), which can leverage contextual information to constrain the sampling process from structural distortion and modulate time step embedding features for better alignment with the input at the next time step. Third, to rapidly generalize to a new, unseen dose level with as few resources as possible, we devise a one-shot learning framework to make CoreDiff generalize faster and better using only a single LDCT image (un)paired with NDCT. Extensive experimental results on two datasets demonstrate that our CoreDiff outperforms competing methods in denoising and generalization performance, with a clinically acceptable inference time.

Cross-head Supervision for Crowd Counting with Noisy Annotations

Noisy annotations such as missing annotations and location shifts often exist in crowd counting datasets due to multi-scale head sizes, high occlusion, etc. These noisy annotations severely affect the model training, especially for density map-based methods. To alleviate the negative impact of noisy annotations, we propose a novel crowd counting model with one convolution head and one transformer head, in which these two heads can supervise each other in noisy areas, called Cross-Head Supervision. The resultant model, CHS-Net, can synergize different types of inductive biases for better counting. In addition, we develop a progressive cross-head supervision learning strategy to stabilize the training process and provide more reliable supervision. Extensive experimental results on ShanghaiTech and QNRF datasets demonstrate superior performance over state-of-the-art methods. Code is available at https://github.com/RaccoonDML/CHSNet.

Twin Contrastive Learning with Noisy Labels

Learning from noisy data is a challenging task that significantly degenerates the model performance. In this paper, we present TCL, a novel twin contrastive learning model to learn robust representations and handle noisy labels for classification. Specifically, we construct a Gaussian mixture model (GMM) over the representations by injecting the supervised model predictions into GMM to link label-free latent variables in GMM with label-noisy annotations. Then, TCL detects the examples with wrong labels as the out-of-distribution examples by another two-component GMM, taking into account the data distribution. We further propose a cross-supervision with an entropy regularization loss that bootstraps the true targets from model predictions to handle the noisy labels. As a result, TCL can learn discriminative representations aligned with estimated labels through mixup and contrastive learning. Extensive experimental results on several standard benchmarks and real-world datasets demonstrate the superior performance of TCL. In particular, TCL achieves 7.5\% improvements on CIFAR-10 with 90\% noisy label -- an extremely noisy scenario. The source code is available at \url{https://github.com/Hzzone/TCL}.

LIT-Former: Linking In-plane and Through-plane Transformers for Simultaneous CT Image Denoising and Deblurring

This paper studies 3D low-dose computed tomography (CT) imaging. Although various deep learning methods were developed in this context, typically they perform denoising due to low-dose and deblurring for super-resolution separately. Up to date, little work was done for simultaneous in-plane denoising and through-plane deblurring, which is important to improve clinical CT images. For this task, a straightforward method is to directly train an end-to-end 3D network. However, it demands much more training data and expensive computational costs. Here, we propose to link in-plane and through-plane transformers for simultaneous in-plane denoising and through-plane deblurring, termed as LIT-Former, which can efficiently synergize in-plane and through-plane sub-tasks for 3D CT imaging and enjoy the advantages of both convolution and transformer networks. LIT-Former has two novel designs: efficient multi-head self-attention modules (eMSM) and efficient convolutional feed-forward networks (eCFN). First, eMSM integrates in-plane 2D self-attention and through-plane 1D self-attention to efficiently capture global interactions of 3D self-attention, the core unit of transformer networks. Second, eCFN integrates 2D convolution and 1D convolution to extract local information of 3D convolution in the same fashion. As a result, the proposed LIT-Former synergizes these two sub-tasks, significantly reducing the computational complexity as compared to 3D counterparts and enabling rapid convergence. Extensive experimental results on simulated and clinical datasets demonstrate superior performance over state-of-the-art models.

CORE: Learning Consistent Ordinal REpresentations for Image Ordinal Estimation

The goal of image ordinal estimation is to estimate the ordinal label of a given image with a convolutional neural network. Existing methods are mainly based on ordinal regression and particularly focus on modeling the ordinal mapping from the feature representation of the input to the ordinal label space. However, the manifold of the resultant feature representations does not maintain the intrinsic ordinal relations of interest, which hinders the effectiveness of the image ordinal estimation. Therefore, this paper proposes learning intrinsic Consistent Ordinal REpresentations (CORE) from ordinal relations residing in groundtruth labels while encouraging the feature representations to embody the ordinal low-dimensional manifold. First, we develop an ordinal totally ordered set (toset) distribution (OTD), which can (i) model the label embeddings to inherit ordinal information and measure distances between ordered labels of samples in a neighborhood, and (ii) model the feature embeddings to infer numerical magnitude with unknown ordinal information among the features of different samples. Second, through OTD, we convert the feature representations and labels into the same embedding space for better alignment, and then compute the Kullback Leibler (KL) divergence between the ordinal labels and feature representations to endow the latent space with consistent ordinal relations. Third, we optimize the KL divergence through ordinal prototype-constrained convex programming with dual decomposition; our theoretical analysis shows that we can obtain the optimal solutions via gradient backpropagation. Extensive experimental results demonstrate that the proposed CORE can accurately construct an ordinal latent space and significantly enhance existing deep ordinal regression methods to achieve better results.

Temporal Modeling Matters: A Novel Temporal Emotional Modeling Approach for Speech Emotion Recognition

Speech emotion recognition (SER) plays a vital role in improving the interactions between humans and machines by inferring human emotion and affective states from speech signals. Whereas recent works primarily focus on mining spatiotemporal information from hand-crafted features, we explore how to model the temporal patterns of speech emotions from dynamic temporal scales. Towards that goal, we introduce a novel temporal emotional modeling approach for SER, termed Temporal-aware bI-direction Multi-scale Network (TIM-Net), which learns multi-scale contextual affective representations from various time scales. Specifically, TIM-Net first employs temporal-aware blocks to learn temporal affective representation, then integrates complementary information from the past and the future to enrich contextual representations, and finally, fuses multiple time scale features for better adaptation to the emotional variation. Extensive experimental results on six benchmark SER datasets demonstrate the superior performance of TIM-Net, gaining 2.34% and 2.61% improvements of the average UAR and WAR over the second-best on each corpus. Remarkably, TIM-Net outperforms the latest domain-adaptation method on the cross-corpus SER tasks, demonstrating strong generalizability.

When Age-Invariant Face Recognition Meets Face Age Synthesis: A Multi-Task Learning Framework and A New Benchmark

To minimize the impact of age variation on face recognition, age-invariant face recognition (AIFR) extracts identity-related discriminative features by minimizing the correlation between identity- and age-related features while face age synthesis (FAS) eliminates age variation by converting the faces in different age groups to the same group. However, AIFR lacks visual results for model interpretation and FAS compromises downstream recognition due to artifacts. Therefore, we propose a unified, multi-task framework to jointly handle these two tasks, termed MTLFace, which can learn the age-invariant identity-related representation for face recognition while achieving pleasing face synthesis for model interpretation. Specifically, we propose an attention-based feature decomposition to decompose the mixed face features into two uncorrelated components -- identity- and age-related features -- in a spatially constrained way. Unlike the conventional one-hot encoding that achieves group-level FAS, we propose a novel identity conditional module to achieve identity-level FAS, which can improve the age smoothness of synthesized faces through a weight-sharing strategy. Benefiting from the proposed multi-task framework, we then leverage those high-quality synthesized faces from FAS to further boost AIFR via a novel selective fine-tuning strategy. Furthermore, to advance both AIFR and FAS, we collect and release a large cross-age face dataset with age and gender annotations, and a new benchmark specifically designed for tracing long-missing children. Extensive experimental results on five benchmark cross-age datasets demonstrate that MTLFace yields superior performance for both AIFR and FAS. We further validate MTLFace on two popular general face recognition datasets, obtaining competitive performance on face recognition in the wild. Code is available at http://hzzone.github.io/MTLFace.