Learning Modular Safe Policies in the Bandit Setting with Application to Adaptive Clinical Trials

The stochastic multi-armed bandit problem is a well-known model for studying the exploration-exploitation trade-off. It has significant possible applications in adaptive clinical trials, which allow for dynamic changes in the treatment allocation probabilities of patients. However, most bandit learning algorithms are designed with the goal of minimizing the expected regret. While this approach is useful in many areas, in clinical trials, it can be sensitive to outlier data, especially when the sample size is small. In this paper, we define and study a new robustness criterion for bandit problems. Specifically, we consider optimizing a function of the distribution of returns as a regret measure. This provides practitioners more flexibility to define an appropriate regret measure. The learning algorithm we propose to solve this type of problem is a modification of the BESA algorithm [Baransi et al., 2014], which considers a more general version of regret. We present a regret bound for our approach and evaluate it empirically both on synthetic problems as well as on a dataset from the clinical trial literature. Our approach compares favorably to a suite of standard bandit algorithms.

Uncertainty Aware Learning from Demonstrations in Multiple Contexts using Bayesian Neural Networks

Diversity of environments is a key challenge that causes learned robotic controllers to fail due to the discrepancies between the training and evaluation conditions. Training from demonstrations in various conditions can mitigate---but not completely prevent---such failures. Learned controllers such as neural networks typically do not have a notion of uncertainty that allows to diagnose an offset between training and testing conditions, and potentially intervene. In this work, we propose to use Bayesian Neural Networks, which have such a notion of uncertainty. We show that uncertainty can be leveraged to consistently detect situations in high-dimensional simulated and real robotic domains in which the performance of the learned controller would be sub-par. Also, we show that such an uncertainty based solution allows making an informed decision about when to invoke a fallback strategy. One fallback strategy is to request more data. We empirically show that providing data only when requested results in increased data-efficiency.

The Termination Critic

In this work, we consider the problem of autonomously discovering behavioral abstractions, or options, for reinforcement learning agents. We propose an algorithm that focuses on the termination condition, as opposed to -- as is common -- the policy. The termination condition is usually trained to optimize a control objective: an option ought to terminate if another has better value. We offer a different, information-theoretic perspective, and propose that terminations should focus instead on the compressibility of the option's encoding -- arguably a key reason for using abstractions. To achieve this algorithmically, we leverage the classical options framework, and learn the option transition model as a "critic" for the termination condition. Using this model, we derive gradients that optimize the desired criteria. We show that the resulting options are non-trivial, intuitively meaningful, and useful for learning and planning.

Clustering-Oriented Representation Learning with Attractive-Repulsive Loss

The standard loss function used to train neural network classifiers, categorical cross-entropy (CCE), seeks to maximize accuracy on the training data; building useful representations is not a necessary byproduct of this objective. In this work, we propose clustering-oriented representation learning (COREL) as an alternative to CCE in the context of a generalized attractive-repulsive loss framework. COREL has the consequence of building latent representations that collectively exhibit the quality of natural clustering within the latent space of the final hidden layer, according to a predefined similarity function. Despite being simple to implement, COREL variants outperform or perform equivalently to CCE in a variety of scenarios, including image and news article classification using both feed-forward and convolutional neural networks. Analysis of the latent spaces created with different similarity functions facilitates insights on the different use cases COREL variants can satisfy, where the Cosine-COREL variant makes a consistently clusterable latent space, while Gaussian-COREL consistently obtains better classification accuracy than CCE.

Off-Policy Deep Reinforcement Learning without Exploration

Reinforcement learning traditionally considers the task of balancing exploration and exploitation. This work examines batch reinforcement learning--the task of maximally exploiting a given batch of off-policy data, without further data collection. We demonstrate that due to errors introduced by extrapolation, standard off-policy deep reinforcement learning algorithms, such as DQN and DDPG, are only capable of learning with data correlated to their current policy, making them ineffective for most off-policy applications. We introduce a novel class of off-policy algorithms, batch-constrained reinforcement learning, which restricts the action space to force the agent towards behaving on-policy with respect to a subset of the given data. We extend this notion to deep reinforcement learning, and to the best of our knowledge, present the first continuous control deep reinforcement learning algorithm which can learn effectively from uncorrelated off-policy data.

Environments for Lifelong Reinforcement Learning

To achieve general artificial intelligence, reinforcement learning (RL) agents should learn not only to optimize returns for one specific task but also to constantly build more complex skills and scaffold their knowledge about the world, without forgetting what has already been learned. In this paper, we discuss the desired characteristics of environments that can support the training and evaluation of lifelong reinforcement learning agents, review existing environments from this perspective, and propose recommendations for devising suitable environments in the future.

The Barbados 2018 List of Open Issues in Continual Learning

We want to make progress toward artificial general intelligence, namely general-purpose agents that autonomously learn how to competently act in complex environments. The purpose of this report is to sketch a research outline, share some of the most important open issues we are facing, and stimulate further discussion in the community. The content is based on some of our discussions during a week-long workshop held in Barbados in February 2018.

Temporal Regularization in Markov Decision Process

Several applications of Reinforcement Learning suffer from instability due to high variance. This is especially prevalent in high dimensional domains. Regularization is a commonly used technique in machine learning to reduce variance, at the cost of introducing some bias. Most existing regularization techniques focus on spatial (perceptual) regularization. Yet in reinforcement learning, due to the nature of the Bellman equation, there is an opportunity to also exploit temporal regularization based on smoothness in value estimates over trajectories. This paper explores a class of methods for temporal regularization. We formally characterize the bias induced by this technique using Markov chain concepts. We illustrate the various characteristics of temporal regularization via a sequence of simple discrete and continuous MDPs, and show that the technique provides improvement even in high-dimensional Atari games.

Convergent Tree Backup and Retrace with Function Approximation

Off-policy learning is key to scaling up reinforcement learning as it allows to learn about a target policy from the experience generated by a different behavior policy. Unfortunately, it has been challenging to combine off-policy learning with function approximation and multi-step bootstrapping in a way that leads to both stable and efficient algorithms. In this work, we show that the \textsc{Tree Backup} and \textsc{Retrace} algorithms are unstable with linear function approximation, both in theory and in practice with specific examples. Based on our analysis, we then derive stable and efficient gradient-based algorithms using a quadratic convex-concave saddle-point formulation. By exploiting the problem structure proper to these algorithms, we are able to provide convergence guarantees and finite-sample bounds. The applicability of our new analysis also goes beyond \textsc{Tree Backup} and \textsc{Retrace} and allows us to provide new convergence rates for the GTD and GTD2 algorithms without having recourse to projections or Polyak averaging.

Exploring Uncertainty Measures in Deep Networks for Multiple Sclerosis Lesion Detection and Segmentation

Deep learning (DL) networks have recently been shown to outperform other segmentation methods on various public, medical-image challenge datasets [3,11,16], especially for large pathologies. However, in the context of diseases such as Multiple Sclerosis (MS), monitoring all the focal lesions visible on MRI sequences, even very small ones, is essential for disease staging, prognosis, and evaluating treatment efficacy. Moreover, producing deterministic outputs hinders DL adoption into clinical routines. Uncertainty estimates for the predictions would permit subsequent revision by clinicians. We present the first exploration of multiple uncertainty estimates based on Monte Carlo (MC) dropout [4] in the context of deep networks for lesion detection and segmentation in medical images. Specifically, we develop a 3D MS lesion segmentation CNN, augmented to provide four different voxel-based uncertainty measures based on MC dropout. We train the network on a proprietary, large-scale, multi-site, multi-scanner, clinical MS dataset, and compute lesion-wise uncertainties by accumulating evidence from voxel-wise uncertainties within detected lesions. We analyze the performance of voxel-based segmentation and lesion-level detection by choosing operating points based on the uncertainty. Empirical evidence suggests that uncertainty measures consistently allow us to choose superior operating points compared only using the network's sigmoid output as a probability.