Assessing Economic Viability: A Comparative Analysis of Total Cost of Ownership for Domain-Adapted Large Language Models versus State-of-the-art Counterparts in Chip Design Coding Assistance

This paper presents a comparative analysis of total cost of ownership (TCO) and performance between domain-adapted large language models (LLM) and state-of-the-art (SoTA) LLMs , with a particular emphasis on tasks related to coding assistance for chip design. We examine the TCO and performance metrics of a domain-adaptive LLM, ChipNeMo, against two leading LLMs, Claude 3 Opus and ChatGPT-4 Turbo, to assess their efficacy in chip design coding generation. Through a detailed evaluation of the accuracy of the model, training methodologies, and operational expenditures, this study aims to provide stakeholders with critical information to select the most economically viable and performance-efficient solutions for their specific needs. Our results underscore the benefits of employing domain-adapted models, such as ChipNeMo, that demonstrate improved performance at significantly reduced costs compared to their general-purpose counterparts. In particular, we reveal the potential of domain-adapted LLMs to decrease TCO by approximately 90%-95%, with the cost advantages becoming increasingly evident as the deployment scale expands. With expansion of deployment, the cost benefits of ChipNeMo become more pronounced, making domain-adaptive LLMs an attractive option for organizations with substantial coding needs supported by LLMs

Multiple Instance Learning for Glioma Diagnosis using Hematoxylin and Eosin Whole Slide Images: An Indian Cohort Study

The effective management of brain tumors relies on precise typing, subtyping, and grading. This study advances patient care with findings from rigorous multiple instance learning experimentations across various feature extractors and aggregators in brain tumor histopathology. It establishes new performance benchmarks in glioma subtype classification across multiple datasets, including a novel dataset focused on the Indian demographic (IPD- Brain), providing a valuable resource for existing research. Using a ResNet-50, pretrained on histopathology datasets for feature extraction, combined with the Double-Tier Feature Distillation (DTFD) feature aggregator, our approach achieves state-of-the-art AUCs of 88.08 on IPD-Brain and 95.81 on the TCGA-Brain dataset, respectively, for three-way glioma subtype classification. Moreover, it establishes new benchmarks in grading and detecting IHC molecular biomarkers (IDH1R132H, TP53, ATRX, Ki-67) through H&E stained whole slide images for the IPD-Brain dataset. The work also highlights a significant correlation between the model decision-making processes and the diagnostic reasoning of pathologists, underscoring its capability to mimic professional diagnostic procedures.

Multiple Instance Learning for Glioma Diagnosis using Hematoxylin and Eosin Whole Slide Images: An Indian cohort Study

Brain tumors represent a severe and life-threatening condition, demanding precise diagnosis and tailored treatment strategies. This study advances patient care with findings from rigorous multiple-instance-learning experimentations across various feature extractors and aggregators in brain tumor histopathology. It establishes new performance benchmarks in glioma subtype classification across multiple datasets, including a novel dataset focused on the Indian demographic (IPD-Brain), providing a valuable resource for existing research. Using a ResNet-50, pretrained on histopathology datasets, for feature extraction, combined with DTFD feature aggregator, our approach achieves state-of-the-art AUCs of 88.08 on IPD-Brain and 95.81 on TCGA-Brain dataset respectively for three-way glioma subtype classification. Moreover, it establishes new benchmarks in grading and detecting IHC molecular biomarkers (IDH1 (mutant R132H), TP53, ATRX, Ki-67) through H&E stained whole slide images for the IPD-Brain dataset. The work also highlights a significant correlation between the model decision-making processes and the diagnostic reasoning of pathologists, underscoring its capability to mimic professional diagnostic procedures.

NICE: To Optimize In-Context Examples or Not?

Recent work shows that in-context learning and optimization of in-context examples (ICE) can significantly improve the accuracy of large language models (LLMs) on a wide range of tasks, leading to an apparent consensus that ICE optimization is crucial for better performance. However, most of these studies assume a fixed or no instruction provided in the prompt. We challenge this consensus by investigating the necessity of optimizing ICE when task-specific instructions are provided and find that there are tasks for which it yields diminishing returns. In particular, using a diverse set of tasks and a systematically created instruction set with gradually added details, we find that as the prompt instruction becomes more detailed, the returns on ICE optimization diminish. To characterize this behavior, we introduce a task-specific metric called Normalized Invariability to Choice of Examples (NICE) that quantifies the learnability of tasks from a given instruction, and provides a heuristic that helps decide whether to optimize instructions or ICE for a new task. Given a task, the proposed metric can reliably predict the utility of optimizing ICE compared to using random ICE.

Pre-registration for Predictive Modeling

Amid rising concerns of reproducibility and generalizability in predictive modeling, we explore the possibility and potential benefits of introducing pre-registration to the field. Despite notable advancements in predictive modeling, spanning core machine learning tasks to various scientific applications, challenges such as overlooked contextual factors, data-dependent decision-making, and unintentional re-use of test data have raised questions about the integrity of results. To address these issues, we propose adapting pre-registration practices from explanatory modeling to predictive modeling. We discuss current best practices in predictive modeling and their limitations, introduce a lightweight pre-registration template, and present a qualitative study with machine learning researchers to gain insight into the effectiveness of pre-registration in preventing biased estimates and promoting more reliable research outcomes. We conclude by exploring the scope of problems that pre-registration can address in predictive modeling and acknowledging its limitations within this context.

GAR-meets-RAG Paradigm for Zero-Shot Information Retrieval

Given a query and a document corpus, the information retrieval (IR) task is to output a ranked list of relevant documents. Combining large language models (LLMs) with embedding-based retrieval models, recent work shows promising results on the zero-shot retrieval problem, i.e., no access to labeled data from the target domain. Two such popular paradigms are generation-augmented retrieval or GAR (generate additional context for the query and then retrieve), and retrieval-augmented generation or RAG (retrieve relevant documents as context and then generate answers). The success of these paradigms hinges on (i) high-recall retrieval models, which are difficult to obtain in the zero-shot setting, and (ii) high-precision (re-)ranking models which typically need a good initialization. In this work, we propose a novel GAR-meets-RAG recurrence formulation that overcomes the challenges of existing paradigms. Our method iteratively improves retrieval (via GAR) and rewrite (via RAG) stages in the zero-shot setting. A key design principle is that the rewrite-retrieval stages improve the recall of the system and a final re-ranking stage improves the precision. We conduct extensive experiments on zero-shot passage retrieval benchmarks, BEIR and TREC-DL. Our method establishes a new state-of-the-art in the BEIR benchmark, outperforming previous best results in Recall@100 and nDCG@10 metrics on 6 out of 8 datasets, with up to 17% relative gains over the previous best.

Causal Inference Using LLM-Guided Discovery

At the core of causal inference lies the challenge of determining reliable causal graphs solely based on observational data. Since the well-known backdoor criterion depends on the graph, any errors in the graph can propagate downstream to effect inference. In this work, we initially show that complete graph information is not necessary for causal effect inference; the topological order over graph variables (causal order) alone suffices. Further, given a node pair, causal order is easier to elicit from domain experts compared to graph edges since determining the existence of an edge can depend extensively on other variables. Interestingly, we find that the same principle holds for Large Language Models (LLMs) such as GPT-3.5-turbo and GPT-4, motivating an automated method to obtain causal order (and hence causal effect) with LLMs acting as virtual domain experts. To this end, we employ different prompting strategies and contextual cues to propose a robust technique of obtaining causal order from LLMs. Acknowledging LLMs' limitations, we also study possible techniques to integrate LLMs with established causal discovery algorithms, including constraint-based and score-based methods, to enhance their performance. Extensive experiments demonstrate that our approach significantly improves causal ordering accuracy as compared to discovery algorithms, highlighting the potential of LLMs to enhance causal inference across diverse fields.

Faithful Explanations of Black-box NLP Models Using LLM-generated Counterfactuals

Causal explanations of the predictions of NLP systems are essential to ensure safety and establish trust. Yet, existing methods often fall short of explaining model predictions effectively or efficiently and are often model-specific. In this paper, we address model-agnostic explanations, proposing two approaches for counterfactual (CF) approximation. The first approach is CF generation, where a large language model (LLM) is prompted to change a specific text concept while keeping confounding concepts unchanged. While this approach is demonstrated to be very effective, applying LLM at inference-time is costly. We hence present a second approach based on matching, and propose a method that is guided by an LLM at training-time and learns a dedicated embedding space. This space is faithful to a given causal graph and effectively serves to identify matches that approximate CFs. After showing theoretically that approximating CFs is required in order to construct faithful explanations, we benchmark our approaches and explain several models, including LLMs with billions of parameters. Our empirical results demonstrate the excellent performance of CF generation models as model-agnostic explainers. Moreover, our matching approach, which requires far less test-time resources, also provides effective explanations, surpassing many baselines. We also find that Top-K techniques universally improve every tested method. Finally, we showcase the potential of LLMs in constructing new benchmarks for model explanation and subsequently validate our conclusions. Our work illuminates new pathways for efficient and accurate approaches to interpreting NLP systems.

Large Language Models as Annotators: Enhancing Generalization of NLP Models at Minimal Cost

State-of-the-art supervised NLP models achieve high accuracy but are also susceptible to failures on inputs from low-data regimes, such as domains that are not represented in training data. As an approximation to collecting ground-truth labels for the specific domain, we study the use of large language models (LLMs) for annotating inputs and improving the generalization of NLP models. Specifically, given a budget for LLM annotations, we present an algorithm for sampling the most informative inputs to annotate and retrain the NLP model. We find that popular active learning strategies such as uncertainty-based sampling do not work well. Instead, we propose a sampling strategy based on the difference in prediction scores between the base model and the finetuned NLP model, utilizing the fact that most NLP models are finetuned from a base model. Experiments with classification (semantic similarity) and ranking (semantic search) tasks show that our sampling strategy leads to significant gains in accuracy for both the training and target domains.