An Innovative Framework for Breast Cancer Detection Using Pyramid Adaptive Atrous Convolution, Transformer Integration, and Multi-Scale Feature Fusion

Breast cancer is one of the most common cancers among women worldwide, and its accurate and timely diagnosis plays a critical role in improving treatment outcomes. This thesis presents an innovative framework for detecting malignant masses in mammographic images by integrating the Pyramid Adaptive Atrous Convolution (PAAC) and Transformer architectures. The proposed approach utilizes Multi-Scale Feature Fusion to enhance the extraction of features from benign and malignant tissues and combines Dice Loss and Focal Loss functions to improve the model's learning process, effectively reducing errors in binary breast cancer classification and achieving high accuracy and efficiency. In this study, a comprehensive dataset of breast cancer images from INbreast, MIAS, and DDSM was preprocessed through data augmentation and contrast enhancement and resized to 227x227 pixels for model training. Leveraging the Transformer's ability to manage long-range dependencies with Self-Attention mechanisms, the proposed model achieved high accuracy in detecting cancerous masses, outperforming foundational models such as BreastNet, DeepMammo, Multi-Scale CNN, Swin-Unet, and SegFormer. The final evaluation results for the proposed model include an accuracy of 98.5\%, sensitivity of 97.8\%, specificity of 96.3\%, F1-score of 98.2\%, and overall precision of 97.9\%. These metrics demonstrate a significant improvement over traditional methods and confirm the model's effectiveness in identifying cancerous masses in complex scenarios and large datasets. This model shows potential as a reliable and efficient tool for breast cancer diagnosis and can be effectively integrated into medical diagnostic systems.

GRAFNet: Multiscale Retinal Processing via Guided Cortical Attention Feedback for Enhancing Medical Image Polyp Segmentation

Accurate polyp segmentation in colonoscopy is essential for cancer prevention but remains challenging due to: (1) high morphological variability (from flat to protruding lesions), (2) strong visual similarity to normal structures such as folds and vessels, and (3) the need for robust multi-scale detection. Existing deep learning approaches suffer from unidirectional processing, weak multi-scale fusion, and the absence of anatomical constraints, often leading to false positives (over-segmentation of normal structures) and false negatives (missed subtle flat lesions). We propose GRAFNet, a biologically inspired architecture that emulates the hierarchical organisation of the human visual system. GRAFNet integrates three key modules: (1) a Guided Asymmetric Attention Module (GAAM) that mimics orientation-tuned cortical neurones to emphasise polyp boundaries, (2) a MultiScale Retinal Module (MSRM) that replicates retinal ganglion cell pathways for parallel multi-feature analysis, and (3) a Guided Cortical Attention Feedback Module (GCAFM) that applies predictive coding for iterative refinement. These are unified in a Polyp Encoder-Decoder Module (PEDM) that enforces spatial-semantic consistency via resolution-adaptive feedback. Extensive experiments on five public benchmarks (Kvasir-SEG, CVC-300, CVC-ColonDB, CVC-Clinic, and PolypGen) demonstrate consistent state-of-the-art performance, with 3-8% Dice improvements and 10-20% higher generalisation over leading methods, while offering interpretable decision pathways. This work establishes a paradigm in which neural computation principles bridge the gap between AI accuracy and clinically trustworthy reasoning. Code is available at https://github.com/afofanah/GRAFNet.

Learning with Geometric Priors in U-Net Variants for Polyp Segmentation

Accurate and robust polyp segmentation is essential for early colorectal cancer detection and for computer-aided diagnosis. While convolutional neural network-, Transformer-, and Mamba-based U-Net variants have achieved strong performance, they still struggle to capture geometric and structural cues, especially in low-contrast or cluttered colonoscopy scenes. To address this challenge, we propose a novel Geometric Prior-guided Module (GPM) that injects explicit geometric priors into U-Net-based architectures for polyp segmentation. Specifically, we fine-tune the Visual Geometry Grounded Transformer (VGGT) on a simulated ColonDepth dataset to estimate depth maps of polyp images tailored to the endoscopic domain. These depth maps are then processed by GPM to encode geometric priors into the encoder's feature maps, where they are further refined using spatial and channel attention mechanisms that emphasize both local spatial and global channel information. GPM is plug-and-play and can be seamlessly integrated into diverse U-Net variants. Extensive experiments on five public polyp segmentation datasets demonstrate consistent gains over three strong baselines. Code and the generated depth maps are available at: https://github.com/fvazqu/GPM-PolypSeg

Efficient endometrial carcinoma screening via cross-modal synthesis and gradient distillation

Early detection of myometrial invasion is critical for the staging and life-saving management of endometrial carcinoma (EC), a prevalent global malignancy. Transvaginal ultrasound serves as the primary, accessible screening modality in resource-constrained primary care settings; however, its diagnostic reliability is severely hindered by low tissue contrast, high operator dependence, and a pronounced scarcity of positive pathological samples. Existing artificial intelligence solutions struggle to overcome this severe class imbalance and the subtle imaging features of invasion, particularly under the strict computational limits of primary care clinics. Here we present an automated, highly efficient two-stage deep learning framework that resolves both data and computational bottlenecks in EC screening. To mitigate pathological data scarcity, we develop a structure-guided cross-modal generation network that synthesizes diverse, high-fidelity ultrasound images from unpaired magnetic resonance imaging (MRI) data, strictly preserving clinically essential anatomical junctions. Furthermore, we introduce a lightweight screening network utilizing gradient distillation, which transfers discriminative knowledge from a high-capacity teacher model to dynamically guide sparse attention towards task-critical regions. Evaluated on a large, multicenter cohort of 7,951 participants, our model achieves a sensitivity of 99.5\%, a specificity of 97.2\%, and an area under the curve of 0.987 at a minimal computational cost (0.289 GFLOPs), substantially outperforming the average diagnostic accuracy of expert sonographers. Our approach demonstrates that combining cross-modal synthetic augmentation with knowledge-driven efficient modeling can democratize expert-level, real-time cancer screening for resource-constrained primary care settings.

Conditional Random Fields for Interactive Refinement of Histopathological Predictions

Assisting pathologists in the analysis of histopathological images has high clinical value, as it supports cancer detection and staging. In this context, histology foundation models have recently emerged. Among them, Vision-Language Models (VLMs) provide strong yet imperfect zero-shot predictions. We propose to refine these predictions by adapting Conditional Random Fields (CRFs) to histopathological applications, requiring no additional model training. We present HistoCRF, a CRF-based framework, with a novel definition of the pairwise potential that promotes label diversity and leverages expert annotations. We consider three experiments: without annotations, with expert annotations, and with iterative human-in-the-loop annotations that progressively correct misclassified patches. Experiments on five patch-level classification datasets covering different organs and diseases demonstrate average accuracy gains of 16.0% without annotations and 27.5% with only 100 annotations, compared to zero-shot predictions. Moreover, integrating a human in the loop reaches a further gain of 32.6% with the same number of annotations. The code will be made available on https://github.com/tgodelaine/HistoCRF.

Kidney Cancer Detection Using 3D-Based Latent Diffusion Models

In this work, we present a novel latent diffusion-based pipeline for 3D kidney anomaly detection on contrast-enhanced abdominal CT. The method combines Denoising Diffusion Probabilistic Models (DDPMs), Denoising Diffusion Implicit Models (DDIMs), and Vector-Quantized Generative Adversarial Networks (VQ-GANs). Unlike prior slice-wise approaches, our method operates directly on an image volume and leverages weak supervision with only case-level pseudo-labels. We benchmark our approach against state-of-the-art supervised segmentation and detection models. This study demonstrates the feasibility and promise of 3D latent diffusion for weakly supervised anomaly detection. While the current results do not yet match supervised baselines, they reveal key directions for improving reconstruction fidelity and lesion localization. Our findings provide an important step toward annotation-efficient, generative modeling of complex abdominal anatomy.

Unsupervised Anomaly Detection of Diseases in the Female Pelvis for Real-Time MR Imaging

Pelvic diseases in women of reproductive age represent a major global health burden, with diagnosis frequently delayed due to high anatomical variability, complicating MRI interpretation. Existing AI approaches are largely disease-specific and lack real-time compatibility, limiting generalizability and clinical integration. To address these challenges, we establish a benchmark framework for disease- and parameter-agnostic, real-time-compatible unsupervised anomaly detection in pelvic MRI. The method uses a residual variational autoencoder trained exclusively on healthy sagittal T2-weighted scans acquired across diverse imaging protocols to model normal pelvic anatomy. During inference, reconstruction error heatmaps indicate deviations from learned healthy structure, enabling detection of pathological regions without labeled abnormal data. The model is trained on 294 healthy scans and augmented with diffusion-generated synthetic data to improve robustness. Quantitative evaluation on the publicly available Uterine Myoma MRI Dataset yields an average area-under-the-curve (AUC) value of 0.736, with 0.828 sensitivity and 0.692 specificity. Additional inter-observer clinical evaluation extends analysis to endometrial cancer, endometriosis, and adenomyosis, revealing the influence of anatomical heterogeneity and inter-observer variability on performance interpretation. With a reconstruction time of approximately 92.6 frames per second, the proposed framework establishes a baseline for unsupervised anomaly detection in the female pelvis and supports future integration into real-time MRI. Code is available upon request (https://github.com/AniKnu/UADPelvis), prospective data sets are available for academic collaboration.

Multi-head automated segmentation by incorporating detection head into the contextual layer neural network

Deep learning based auto segmentation is increasingly used in radiotherapy, but conventional models often produce anatomically implausible false positives, or hallucinations, in slices lacking target structures. We propose a gated multi-head Transformer architecture based on Swin U-Net, augmented with inter-slice context integration and a parallel detection head, which jointly performs slice-level structure detection via a multi-layer perceptron and pixel-level segmentation through a context-enhanced stream. Detection outputs gate the segmentation predictions to suppress false positives in anatomically invalid slices, and training uses slice-wise Tversky loss to address class imbalance. Experiments on the Prostate-Anatomical-Edge-Cases dataset from The Cancer Imaging Archive demonstrate that the gated model substantially outperforms a non-gated segmentation-only baseline, achieving a mean Dice loss of $0.013 \pm 0.036$ versus $0.732 \pm 0.314$, with detection probabilities strongly correlated with anatomical presence, effectively eliminating spurious segmentations. In contrast, the non-gated model exhibited higher variability and persistent false positives across all slices. These results indicate that detection-based gating enhances robustness and anatomical plausibility in automated segmentation applications, reducing hallucinated predictions without compromising segmentation quality in valid slices, and offers a promising approach for improving the reliability of clinical radiotherapy auto-contouring workflows.

EndoCaver: Handling Fog, Blur and Glare in Endoscopic Images via Joint Deblurring-Segmentation

Endoscopic image analysis is vital for colorectal cancer screening, yet real-world conditions often suffer from lens fogging, motion blur, and specular highlights, which severely compromise automated polyp detection. We propose EndoCaver, a lightweight transformer with a unidirectional-guided dual-decoder architecture, enabling joint multi-task capability for image deblurring and segmentation while significantly reducing computational complexity and model parameters. Specifically, it integrates a Global Attention Module (GAM) for cross-scale aggregation, a Deblurring-Segmentation Aligner (DSA) to transfer restoration cues, and a cosine-based scheduler (LoCoS) for stable multi-task optimisation. Experiments on the Kvasir-SEG dataset show that EndoCaver achieves 0.922 Dice on clean data and 0.889 under severe image degradation, surpassing state-of-the-art methods while reducing model parameters by 90%. These results demonstrate its efficiency and robustness, making it well-suited for on-device clinical deployment. Code is available at https://github.com/ReaganWu/EndoCaver.

Data Augmentation for High-Fidelity Generation of CAR-T/NK Immunological Synapse Images

Chimeric antigen receptor (CAR)-T and NK cell immunotherapies have transformed cancer treatment, and recent studies suggest that the quality of the CAR-T/NK cell immunological synapse (IS) may serve as a functional biomarker for predicting therapeutic efficacy. Accurate detection and segmentation of CAR-T/NK IS structures using artificial neural networks (ANNs) can greatly increase the speed and reliability of IS quantification. However, a persistent challenge is the limited size of annotated microscopy datasets, which restricts the ability of ANNs to generalize. To address this challenge, we integrate two complementary data-augmentation frameworks. First, we employ Instance Aware Automatic Augmentation (IAAA), an automated, instance-preserving augmentation method that generates synthetic CAR-T/NK IS images and corresponding segmentation masks by applying optimized augmentation policies to original IS data. IAAA supports multiple imaging modalities (e.g., fluorescence and brightfield) and can be applied directly to CAR-T/NK IS images derived from patient samples. In parallel, we introduce a Semantic-Aware AI Augmentation (SAAA) pipeline that combines a diffusion-based mask generator with a Pix2Pix conditional image synthesizer. This second method enables the creation of diverse, anatomically realistic segmentation masks and produces high-fidelity CAR-T/NK IS images aligned with those masks, further expanding the training corpus beyond what IAAA alone can provide. Together, these augmentation strategies generate synthetic images whose visual and structural properties closely match real IS data, significantly improving CAR-T/NK IS detection and segmentation performance. By enhancing the robustness and accuracy of IS quantification, this work supports the development of more reliable imaging-based biomarkers for predicting patient response to CAR-T/NK immunotherapy.