Explainability Through Human-Centric Design for XAI in Lung Cancer Detection

Deep learning models have shown promise in lung pathology detection from chest X-rays, but widespread clinical adoption remains limited due to opaque model decision-making. In prior work, we introduced ClinicXAI, a human-centric, expert-guided concept bottleneck model (CBM) designed for interpretable lung cancer diagnosis. We now extend that approach and present XpertXAI, a generalizable expert-driven model that preserves human-interpretable clinical concepts while scaling to detect multiple lung pathologies. Using a high-performing InceptionV3-based classifier and a public dataset of chest X-rays with radiology reports, we compare XpertXAI against leading post-hoc explainability methods and an unsupervised CBM, XCBs. We assess explanations through comparison with expert radiologist annotations and medical ground truth. Although XpertXAI is trained for multiple pathologies, our expert validation focuses on lung cancer. We find that existing techniques frequently fail to produce clinically meaningful explanations, omitting key diagnostic features and disagreeing with radiologist judgments. XpertXAI not only outperforms these baselines in predictive accuracy but also delivers concept-level explanations that better align with expert reasoning. While our focus remains on explainability in lung cancer detection, this work illustrates how human-centric model design can be effectively extended to broader diagnostic contexts - offering a scalable path toward clinically meaningful explainable AI in medical diagnostics.

OODTE: A Differential Testing Engine for the ONNX Optimizer

With $700$ stars on GitHub and part of the official ONNX repository, the ONNX Optimizer consists of the standard method to apply graph-based optimizations on ONNX models. However, its ability to preserve model accuracy across optimizations, has not been rigorously explored. We propose OODTE, a utility to automatically and thoroughly assess the correctness of the ONNX Optimizer. OODTE follows a simple, yet effective differential testing and evaluation approach that can be easily adopted to other compiler optimizers. In particular, OODTE utilizes a number of ONNX models, then optimizes them and executes both the original and the optimized variants across a user-defined set of inputs, while automatically logging any issues with the optimization process. Finally, for successfully optimized models, OODTE compares the results, and, if any accuracy deviations are observed, it iteratively repeats the process for each pass of the ONNX Optimizer, to localize the root cause of the differences observed. Using OODTE, we sourced well-known $130$ models from the official ONNX Model Hub, used for a wide variety of tasks (classification, object detection, semantic segmentation, text summarization, question and answering, sentiment analysis) from the official ONNX model hub. We detected 15 issues, 14 of which were previously unknown, associated with optimizer crashes and accuracy deviations. We also observed $9.2$% of all model instances presenting issues leading into the crash of the optimizer, or the generation of an invalid model while using the primary optimizer strategies. In addition, $30$% of the classification models presented accuracy differences across the original and the optimized model variants, while $16.6$% of semantic segmentation and object detection models are also affected, at least to a limited extent.

Metric-Guided Synthesis of Class Activation Mapping

Class activation mapping (CAM) is a widely adopted class of saliency methods used to explain the behavior of convolutional neural networks (CNNs). These methods generate heatmaps that highlight the parts of the input most relevant to the CNN output. Various CAM methods have been proposed, each distinguished by the expressions used to derive heatmaps. In general, users look for heatmaps with specific properties that reflect different aspects of CNN functionality. These may include similarity to ground truth, robustness, equivariance, and more. Although existing CAM methods implicitly encode some of these properties in their expressions, they do not allow for variability in heatmap generation following the user's intent or domain knowledge. In this paper, we address this limitation by introducing SyCAM, a metric-based approach for synthesizing CAM expressions. Given a predefined evaluation metric for saliency maps, SyCAM automatically generates CAM expressions optimized for that metric. We specifically explore a syntax-guided synthesis instantiation of SyCAM, where CAM expressions are derived based on predefined syntactic constraints and the given metric. Using several established evaluation metrics, we demonstrate the efficacy and flexibility of our approach in generating targeted heatmaps. We compare SyCAM with other well-known CAM methods on three prominent models: ResNet50, VGG16, and VGG19.

CoRPA: Adversarial Image Generation for Chest X-rays Using Concept Vector Perturbations and Generative Models

Deep learning models for medical image classification tasks are becoming widely implemented in AI-assisted diagnostic tools, aiming to enhance diagnostic accuracy, reduce clinician workloads, and improve patient outcomes. However, their vulnerability to adversarial attacks poses significant risks to patient safety. Current attack methodologies use general techniques such as model querying or pixel value perturbations to generate adversarial examples designed to fool a model. These approaches may not adequately address the unique characteristics of clinical errors stemming from missed or incorrectly identified clinical features. We propose the Concept-based Report Perturbation Attack (CoRPA), a clinically-focused black-box adversarial attack framework tailored to the medical imaging domain. CoRPA leverages clinical concepts to generate adversarial radiological reports and images that closely mirror realistic clinical misdiagnosis scenarios. We demonstrate the utility of CoRPA using the MIMIC-CXR-JPG dataset of chest X-rays and radiological reports. Our evaluation reveals that deep learning models exhibiting strong resilience to conventional adversarial attacks are significantly less robust when subjected to CoRPA's clinically-focused perturbations. This underscores the importance of addressing domain-specific vulnerabilities in medical AI systems. By introducing a specialized adversarial attack framework, this study provides a foundation for developing robust, real-world-ready AI models in healthcare, ensuring their safe and reliable deployment in high-stakes clinical environments.

Go-Oracle: Automated Test Oracle for Go Concurrency Bugs

The Go programming language has gained significant traction for developing software, especially in various infrastructure systems. Nonetheless, concurrency bugs have become a prevalent issue within Go, presenting a unique challenge due to the language's dual concurrency mechanisms-communicating sequential processes and shared memory. Detecting concurrency bugs and accurately classifying program executions as pass or fail presents an immense challenge, even for domain experts. We conducted a survey with expert developers at Bytedance that confirmed this challenge. Our work seeks to address the test oracle problem for Go programs, to automatically classify test executions as pass or fail. This problem has not been investigated in the literature for Go programs owing to its distinctive programming model. Our approach involves collecting both passing and failing execution traces from various subject Go programs. We capture a comprehensive array of execution events using the native Go execution tracer. Subsequently, we preprocess and encode these traces before training a transformer-based neural network to effectively classify the traces as either passing or failing. The evaluation of our approach encompasses 8 subject programs sourced from the GoBench repository. These subject programs are routinely used as benchmarks in an industry setting. Encouragingly, our test oracle, Go-Oracle, demonstrates high accuracies even when operating with a limited dataset, showcasing the efficacy and potential of our methodology. Developers at Bytedance strongly agreed that they would use the Go-Oracle tool over the current practice of manual inspections to classify tests for Go programs as pass or fail.

Explainable Attribute-Based Speaker Verification

This paper proposes a fully explainable approach to speaker verification (SV), a task that fundamentally relies on individual speaker characteristics. The opaque use of speaker attributes in current SV systems raises concerns of trust. Addressing this, we propose an attribute-based explainable SV system that identifies speakers by comparing personal attributes such as gender, nationality, and age extracted automatically from voice recordings. We believe this approach better aligns with human reasoning, making it more understandable than traditional methods. Evaluated on the Voxceleb1 test set, the best performance of our system is comparable with the ground truth established when using all correct attributes, proving its efficacy. Whilst our approach sacrifices some performance compared to non-explainable methods, we believe that it moves us closer to the goal of transparent, interpretable AI and lays the groundwork for future enhancements through attribute expansion.

Transparent and Clinically Interpretable AI for Lung Cancer Detection in Chest X-Rays

The rapidly advancing field of Explainable Artificial Intelligence (XAI) aims to tackle the issue of trust regarding the use of complex black-box deep learning models in real-world applications. Existing post-hoc XAI techniques have recently been shown to have poor performance on medical data, producing unreliable explanations which are infeasible for clinical use. To address this, we propose an ante-hoc approach based on concept bottleneck models which introduces for the first time clinical concepts into the classification pipeline, allowing the user valuable insight into the decision-making process. On a large public dataset of chest X-rays and associated medical reports, we focus on the binary classification task of lung cancer detection. Our approach yields improved classification performance in lung cancer detection when compared to baseline deep learning models (F1 > 0.9), while also generating clinically relevant and more reliable explanations than existing techniques. We evaluate our approach against post-hoc image XAI techniques LIME and SHAP, as well as CXR-LLaVA, a recent textual XAI tool which operates in the context of question answering on chest X-rays.

Fix-Con: Automatic Fault Localization and Repair of Deep Learning Model Conversions

Converting deep learning models between frameworks is a common step to maximize model compatibility across devices and leverage optimization features that may be exclusively provided in one deep learning framework. However, this conversion process may be riddled with bugs, making the converted models either undeployable or problematic, considerably degrading their prediction correctness. We propose an automated approach for fault localization and repair, Fix-Con, during model conversion between deep learning frameworks. Fix-Con is capable of detecting and fixing faults introduced in model input, parameters, hyperparameters, and the model graph during conversion. Fix-Con uses a set of fault types mined from surveying conversion issues raised to localize potential conversion faults in the converted target model, and then repairs them appropriately, e.g. replacing the parameters of the target model with those from the source model. This is done iteratively for every image in the dataset with output label differences between the source model and the converted target model until all differences are resolved. We evaluate the effectiveness of Fix-Con in fixing model conversion bugs of three widely used image recognition models converted across four different deep learning frameworks. Overall, Fix-Con was able to either completely repair, or significantly improve the performance of 14 out of the 15 erroneous conversion cases.

Hawkeye: Change-targeted Testing for Android Apps based on Deep Reinforcement Learning

Android Apps are frequently updated to keep up with changing user, hardware, and business demands. Ensuring the correctness of App updates through extensive testing is crucial to avoid potential bugs reaching the end user. Existing Android testing tools generate GUI events focussing on improving the test coverage of the entire App rather than prioritising updates and its impacted elements. Recent research has proposed change-focused testing but relies on random exploration to exercise the updates and impacted GUI elements that is ineffective and slow for large complex Apps with a huge input exploration space. We propose directed testing of App updates with Hawkeye that is able to prioritise executing GUI actions associated with code changes based on deep reinforcement learning from historical exploration data. Our empirical evaluation compares Hawkeye with state-of-the-art model-based and reinforcement learning-based testing tools FastBot2 and ARES using 10 popular open-source and 1 commercial App. We find that Hawkeye is able to generate GUI event sequences targeting changed functions more reliably than FastBot2 and ARES for the open source Apps and the large commercial App. Hawkeye achieves comparable performance on smaller open source Apps with a more tractable exploration space. The industrial deployment of Hawkeye in the development pipeline also shows that Hawkeye is ideal to perform smoke testing for merge requests of a complicated commercial App.

MutateNN: Mutation Testing of Image Recognition Models Deployed on Hardware Accelerators

With the research advancement of Artificial Intelligence in the last years, there are new opportunities to mitigate real-world problems and advance technologically. Image recognition models in particular, are assigned with perception tasks to mitigate complex real-world challenges and lead to new solutions. Furthermore, the computational complexity and demand for resources of such models has also increased. To mitigate this, model optimization and hardware acceleration has come into play, but effectively integrating such concepts is a challenging and error-prone process. In order to allow developers and researchers to explore the robustness of deep learning image recognition models deployed on different hardware acceleration devices, we propose MutateNN, a tool that provides mutation testing and analysis capabilities for that purpose. To showcase its capabilities, we utilized 21 mutations for 7 widely-known pre-trained deep neural network models. We deployed our mutants on 4 different devices of varying computational capabilities and observed discrepancies in mutants related to conditional operations, as well as some unstable behaviour with those related to arithmetic types.