The Color-Clinical Decoupling: Why Perceptual Calibration Fails Clinical Biomarkers in Smartphone Dermatology

Smartphone-based tele-dermatology assumes that colorimetric calibration ensures clinical reliability, yet this remains untested for underrepresented skin phototypes. We investigated whether standard calibration translates to reliable clinical biomarkers using 43,425 images from 965 Korean subjects (Fitzpatrick III-IV) across DSLR, tablet, and smartphone devices. While Linear Color Correction Matrix (CCM) normalization reduced color error by 67-77% -- achieving near-clinical accuracy (Delta E < 2.3) -- this success did not translate to biomarker reliability. We identify a phenomenon termed "color-clinical decoupling": despite perceptual accuracy, the Individual Typology Angle (ITA) showed poor inter-device agreement (ICC = 0.40), while the Melanin Index achieved good agreement (ICC = 0.77). This decoupling is driven by the ITA formula's sensitivity to b* channel noise and is further compounded by anatomical variance. Facial region accounts for 25.2% of color variance -- 3.6x greater than device effects (7.0%) -- challenging the efficacy of single-patch calibration. Our results demonstrate that current colorimetric standards are insufficient for clinical-grade biomarker extraction, necessitating region-aware protocols for mobile dermatology.

UniCorn: Towards Self-Improving Unified Multimodal Models through Self-Generated Supervision

While Unified Multimodal Models (UMMs) have achieved remarkable success in cross-modal comprehension, a significant gap persists in their ability to leverage such internal knowledge for high-quality generation. We formalize this discrepancy as Conduction Aphasia, a phenomenon where models accurately interpret multimodal inputs but struggle to translate that understanding into faithful and controllable synthesis. To address this, we propose UniCorn, a simple yet elegant self-improvement framework that eliminates the need for external data or teacher supervision. By partitioning a single UMM into three collaborative roles: Proposer, Solver, and Judge, UniCorn generates high-quality interactions via self-play and employs cognitive pattern reconstruction to distill latent understanding into explicit generative signals. To validate the restoration of multimodal coherence, we introduce UniCycle, a cycle-consistency benchmark based on a Text to Image to Text reconstruction loop. Extensive experiments demonstrate that UniCorn achieves comprehensive and substantial improvements over the base model across six general image generation benchmarks. Notably, it achieves SOTA performance on TIIF(73.8), DPG(86.8), CompBench(88.5), and UniCycle while further delivering substantial gains of +5.0 on WISE and +6.5 on OneIG. These results highlight that our method significantly enhances T2I generation while maintaining robust comprehension, demonstrating the scalability of fully self-supervised refinement for unified multimodal intelligence.

Aligning Findings with Diagnosis: A Self-Consistent Reinforcement Learning Framework for Trustworthy Radiology Reporting

Multimodal Large Language Models (MLLMs) have shown strong potential for radiology report generation, yet their clinical translation is hindered by architectural heterogeneity and the prevalence of factual hallucinations. Standard supervised fine-tuning often fails to strictly align linguistic outputs with visual evidence, while existing reinforcement learning approaches struggle with either prohibitive computational costs or limited exploration. To address these challenges, we propose a comprehensive framework for self-consistent radiology report generation. First, we conduct a systematic evaluation to identify optimal vision encoder and LLM backbone configurations for medical imaging. Building on this foundation, we introduce a novel "Reason-then-Summarize" architecture optimized via Group Relative Policy Optimization (GRPO). This framework restructures generation into two distinct components: a think block for detailed findings and an answer block for structured disease labels. By utilizing a multi-dimensional composite reward function, we explicitly penalize logical discrepancies between the generated narrative and the final diagnosis. Extensive experiments on the MIMIC-CXR benchmark demonstrate that our method achieves state-of-the-art performance in clinical efficacy metrics and significantly reduces hallucinations compared to strong supervised baselines.

Dream2Flow: Bridging Video Generation and Open-World Manipulation with 3D Object Flow

Generative video modeling has emerged as a compelling tool to zero-shot reason about plausible physical interactions for open-world manipulation. Yet, it remains a challenge to translate such human-led motions into the low-level actions demanded by robotic systems. We observe that given an initial image and task instruction, these models excel at synthesizing sensible object motions. Thus, we introduce Dream2Flow, a framework that bridges video generation and robotic control through 3D object flow as an intermediate representation. Our method reconstructs 3D object motions from generated videos and formulates manipulation as object trajectory tracking. By separating the state changes from the actuators that realize those changes, Dream2Flow overcomes the embodiment gap and enables zero-shot guidance from pre-trained video models to manipulate objects of diverse categories-including rigid, articulated, deformable, and granular. Through trajectory optimization or reinforcement learning, Dream2Flow converts reconstructed 3D object flow into executable low-level commands without task-specific demonstrations. Simulation and real-world experiments highlight 3D object flow as a general and scalable interface for adapting video generation models to open-world robotic manipulation. Videos and visualizations are available at https://dream2flow.github.io/.

Rotterdam artery-vein segmentation (RAV) dataset

Purpose: To provide a diverse, high-quality dataset of color fundus images (CFIs) with detailed artery-vein (A/V) segmentation annotations, supporting the development and evaluation of machine learning algorithms for vascular analysis in ophthalmology. Methods: CFIs were sampled from the longitudinal Rotterdam Study (RS), encompassing a wide range of ages, devices, and capture conditions. Images were annotated using a custom interface that allowed graders to label arteries, veins, and unknown vessels on separate layers, starting from an initial vessel segmentation mask. Connectivity was explicitly verified and corrected using connected component visualization tools. Results: The dataset includes 1024x1024-pixel PNG images in three modalities: original RGB fundus images, contrast-enhanced versions, and RGB-encoded A/V masks. Image quality varied widely, including challenging samples typically excluded by automated quality assessment systems, but judged to contain valuable vascular information. Conclusion: This dataset offers a rich and heterogeneous source of CFIs with high-quality segmentations. It supports robust benchmarking and training of machine learning models under real-world variability in image quality and acquisition settings. Translational Relevance: By including connectivity-validated A/V masks and diverse image conditions, this dataset enables the development of clinically applicable, generalizable machine learning tools for retinal vascular analysis, potentially improving automated screening and diagnosis of systemic and ocular diseases.

LVLM-Aided Alignment of Task-Specific Vision Models

In high-stakes domains, small task-specific vision models are crucial due to their low computational requirements and the availability of numerous methods to explain their results. However, these explanations often reveal that the models do not align well with human domain knowledge, relying instead on spurious correlations. This might result in brittle behavior once deployed in the real-world. To address this issue, we introduce a novel and efficient method for aligning small task-specific vision models with human domain knowledge by leveraging the generalization capabilities of a Large Vision Language Model (LVLM). Our LVLM-Aided Visual Alignment (LVLM-VA) method provides a bidirectional interface that translates model behavior into natural language and maps human class-level specifications to image-level critiques, enabling effective interaction between domain experts and the model. Our method demonstrates substantial improvement in aligning model behavior with human specifications, as validated on both synthetic and real-world datasets. We show that it effectively reduces the model's dependence on spurious features and on group-specific biases, without requiring fine-grained feedback.

The OCR-PT-CT Project: Semi-Automatic Recognition of Ancient Egyptian Hieroglyphs Based on Metric Learning

Digital humanities are significantly transforming how Egyptologists study ancient Egyptian texts. The OCR-PT-CT project proposes a recognition method for hieroglyphs based on images of Coffin Texts (CT) from Adriaan de Buck (1935-1961) and Pyramid Texts (PT) from Middle Kingdom coffins (James Allen, 2006). The system identifies hieroglyphs and transcribes them into Gardiner's codes. A web tool organizes them by spells and witnesses, storing the data in CSV format for integration with the MORTEXVAR dataset, which collects Coffin Texts with metadata, transliterations, and translations for research. Recognition has been addressed in two ways: a Mobilenet neural network trained on 140 hieroglyph classes achieved 93.87 \% accuracy but struggled with underrepresented classes. A novel Deep Metric Learning approach improves flexibility for new or data-limited signs, achieving 97.70 \% accuracy and recognizing more hieroglyphs. Due to its superior performance under class imbalance and adaptability, the final system adopts Deep Metric Learning as the default classifier.

Pixel Super-Resolved Fluorescence Lifetime Imaging Using Deep Learning

Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical adoption remains limited by long pixel dwell times and low signal-to-noise ratio (SNR), which impose a stricter resolution-speed trade-off than conventional optical imaging approaches. Here, we introduce FLIM_PSR_k, a deep learning-based multi-channel pixel super-resolution (PSR) framework that reconstructs high-resolution FLIM images from data acquired with up to a 5-fold increased pixel size. The model is trained using the conditional generative adversarial network (cGAN) framework, which, compared to diffusion model-based alternatives, delivers a more robust PSR reconstruction with substantially shorter inference times, a crucial advantage for practical deployment. FLIM_PSR_k not only enables faster image acquisition but can also alleviate SNR limitations in autofluorescence-based FLIM. Blind testing on held-out patient-derived tumor tissue samples demonstrates that FLIM_PSR_k reliably achieves a super-resolution factor of k = 5, resulting in a 25-fold increase in the space-bandwidth product of the output images and revealing fine architectural features lost in lower-resolution inputs, with statistically significant improvements across various image quality metrics. By increasing FLIM's effective spatial resolution, FLIM_PSR_k advances lifetime imaging toward faster, higher-resolution, and hardware-flexible implementations compatible with low-numerical-aperture and miniaturized platforms, better positioning FLIM for translational applications.

FrameDiffuser: G-Buffer-Conditioned Diffusion for Neural Forward Frame Rendering

Neural rendering for interactive applications requires translating geometric and material properties (G-buffer) to photorealistic images with realistic lighting on a frame-by-frame basis. While recent diffusion-based approaches show promise for G-buffer-conditioned image synthesis, they face critical limitations: single-image models like RGBX generate frames independently without temporal consistency, while video models like DiffusionRenderer are too computationally expensive for most consumer gaming sets ups and require complete sequences upfront, making them unsuitable for interactive applications where future frames depend on user input. We introduce FrameDiffuser, an autoregressive neural rendering framework that generates temporally consistent, photorealistic frames by conditioning on G-buffer data and the models own previous output. After an initial frame, FrameDiffuser operates purely on incoming G-buffer data, comprising geometry, materials, and surface properties, while using its previously generated frame for temporal guidance, maintaining stable, temporal consistent generation over hundreds to thousands of frames. Our dual-conditioning architecture combines ControlNet for structural guidance with ControlLoRA for temporal coherence. A three-stage training strategy enables stable autoregressive generation. We specialize our model to individual environments, prioritizing consistency and inference speed over broad generalization, demonstrating that environment-specific training achieves superior photorealistic quality with accurate lighting, shadows, and reflections compared to generalized approaches.

MatE: Material Extraction from Single-Image via Geometric Prior

The creation of high-fidelity, physically-based rendering (PBR) materials remains a bottleneck in many graphics pipelines, typically requiring specialized equipment and expert-driven post-processing. To democratize this process, we present MatE, a novel method for generating tileable PBR materials from a single image taken under unconstrained, real-world conditions. Given an image and a user-provided mask, MatE first performs coarse rectification using an estimated depth map as a geometric prior, and then employs a dual-branch diffusion model. Leveraging a learned consistency from rotation-aligned and scale-aligned training data, this model further rectify residual distortions from the coarse result and translate it into a complete set of material maps, including albedo, normal, roughness and height. Our framework achieves invariance to the unknown illumination and perspective of the input image, allowing for the recovery of intrinsic material properties from casual captures. Through comprehensive experiments on both synthetic and real-world data, we demonstrate the efficacy and robustness of our approach, enabling users to create realistic materials from real-world image.