Supercharging Bayesian Inference with Reliable AI-Informed Priors

Modern predictive systems encode beliefs that can act as useful prior information for statistical inference in data-limited settings. Using them for prior construction introduces a tradeoff: an informative prior built from a predictive model can sharpen inference from limited data, but also risks propagating error from the model into the posterior. We propose a framework for AI-informed prior elicitation that mitigates this tension by rectifying the AI-induced law that generates synthetic data before using it to inform a prior. The rectified law can be embedded into synthetic data-driven prior elicitation techniques, including as a base measure in a Dirichlet process (DP) prior on the data-generating process. We refer to the resulting prior and corresponding posterior as the rectified AI prior and rectified AI posterior. We establish Gaussian asymptotics for the rectified AI posterior under non-vanishing prior strength and derive a first-order expression for its centering bias. Our rectified AI priors substantially reduce bias compared to standard approaches, improve the coverage of credible intervals, and make AI-powered prior information more reliable. We additionally apply the rectified AI prior to a real skin disease classification task and show that it can meaningfully boost predictive performance.

How Time-Sensitive are IoBNT Networks? An Age of Information Perspective for In-Body Monitoring

This thesis develops a theoretical framework to evaluate the monitoring capability of IoBNT networks. We consider a scenario in which nanosensors passively flow in the bloodstream and detect biomarkers associated with potential diseases, reporting their detections to external gateways on the skin that host a monitoring device. The nanosensors thus realize an artificial point-to-point communication channel between the disease region and the monitor: some packets reach the destination directly, while others are lost through vessel paths that bypass the gateway. We evaluate the network's monitoring capability over this artificial channel using the \ac{AoI} concept, which jointly integrates sample generation (at the disease region), carrying (nanosensor travel through vessels), and delivery (nanosensor-to-gateway) as random events. These are modeled through (i) a Markov model that follows cardiovascular physiology and (ii) channel models of reported nanocommunication technologies. We compute the Markov transition probabilities using a cardiovascular simulator built as a low-complexity electric circuit model of the human vessels. For the nanosensor-to-gateway link, we model two well-known schemes: ultrasonic and terahertz channels. Integrating these components within the \ac{AoI} framework, we report information freshness via the average \ac{PAoI} metric. Under realistic physiological and communication assumptions, fresh information appears on the monitor within tens of seconds. The network is therefore suitable for monitoring tissue-level processes such as bacterial infections, while more adequate architectures are needed to monitor cellular-scale processes, which occur on timescales below tens of seconds.

Uncertainty-Guided Dual-Domain Learning for Reliable Skin Lesion Segmentation

Accurate skin lesion segmentation is vital for dermoscopic Computer-Aided Diagnosis. However, visual ambiguity and morphological irregularity often defeat spatial modeling, necessitating multi-domain architectures. Existing paradigms frequently overlook the active use of prediction uncertainty, leading to deterministic frameworks that suffer from blind cross-domain fusion and overfit to label noise. To address these issues, we propose the Uncertainty-Guided Dual-Domain Network (UGDD-Net). UGDD-Net introduces a novel "Glance-and-Gaze" mechanism to transform uncertainty into an active guiding signal. Specifically, the Uncertainty-Guided Bi-directional Feature Fusion (UGBFF) module uses pixel-level uncertainty to modulate spatial-spectral interactions. The Uncertainty-Guided Graph Refinement (UGGR) module constructs a topology-aware graph to propagate reliable semantic consensus and refine uncertain nodes. Finally, the Uncertainty-Guided Margin-Adaptive Loss (UGML) enforces strict constraints on confident pixels while relaxing penalties on uncertain ones to improve statistical calibration. Extensive experiments on ISIC2017, ISIC2018, PH2, and HAM10000 datasets demonstrate that UGDD-Net achieves state-of-the-art performance, especially on "Hard Samples". Our uncertainty maps align with expert inter-observer variability, providing robust interpretability for human-machine collaborative diagnosis.

Few-Shot Learning Pipeline for Monkeypox Skin Disease Classification Using CNN Feature Extractors

Despite the strong performance of Convolutional Neural Networks (CNNs) in disease classification, their effectiveness often depends on access to large annotated datasets, which is an impractical requirement for emerging or rare conditions such as Monkeypox. To overcome this limitation, we propose a few-shot learning (FSL) framework that employs SimpleShot, a lightweight, non-parametric, inductive classifier, for Monkeypox and pox-like skin disease recognition from limited labeled examples. The proposed pipeline passes the skin lesion images through a frozen, pretrained CNN backbone to obtain feature embeddings, which are then classified via SimpleShot using nearest-centroid comparisons in a normalized embedding space. We systematically benchmark six widely used CNN backbones as feature extractors under consistent experimental settings, enabling fair comparison. Experiments on three publicly available datasets (MSLD v1.0, MSID, and MSLD v2.0) are conducted across 2-way, 4-way, and 6-way tasks with 1-shot, 5-shot, and 10-shot configurations. Among all models, MobileNetV2_100 consistently achieves the highest accuracy. In addition, we present a cross-dataset evaluation for Monkeypox classification, revealing that binary Mpox-vs-Others transfer remains comparatively stable while multi-class performance degrades significantly under domain shift. Together, these results demonstrate the practical utility of combining inductive FSL methods with lightweight CNN backbones and highlight the importance of domain robustness for reliable real-world clinical deployment.

Physiologically Grounded Driver Behavior Classification: SHAP-Driven Elite Feature Selection and Hybrid Gradient Boosting for Multimodal Physiological Signals

An interpretable and scalable framework for decoding driving behaviors from multimodal physiological signals is proposed in this study. We utilize multimodal physiological driving behavior large-scale dataset comprising synchronized electroencephalogram (EEG), electromyography (EMG), and galvanic skin response (GSR) signals. Our approach involves rigorous preprocessing followed by a domain-specific feature extraction pipeline targeting time-domain, frequency-domain, and derived physiological indices. To address high dimensionality, we employ SHAP-based elite feature selection, retaining the top 250 features to reduce computational overhead while preserving predictive power. Hyperparameter optimization for extreme gradient boosting (XGBoost) and light gradient boosting machine (LightGBM) models is conducted using Bayesian optimization via Optuna. Finally, a weighted soft-voting ensemble is constructed to leverage the complementary strengths of both gradient boosting frameworks. The results demonstrate that the proposed ensemble achieves a test accuracy of 80.91% and a macro-F1 score of 0.79, significantly outperforming single-modality baselines and traditional machine learning models. Ablation studies confirm an 8% performance gain over the best single modality (EEG), validating the necessity of multimodal fusion. SHAP analysis further validates the physiological plausibility of the model, revealing that the EEG contributes the majority of predictive weight, GSR and EMG features provide critical discriminatory signals for high-arousal and motor-intensive maneuvers.

Exploring Clustering Capability of Inpainting Model Embeddings for Pattern-based Individual Identification

In this paper, we explore deep learning techniques for individual identification of animals based on their skin patterns. Individual identification is crucial in biodiversity monitoring, since it enables analysis of decline or growth of populations, or intra-species interactions within populations. Models trained for the task of individual identification often do not focus on the skin pattern of animals, but on background details or body shape details. These characteristics are not individually specific, or can change drastically through time. We focus on techniques that will make machine learning models more responsive to skin pattern structure when extracting individual visual embeddings from images. For this, we explore image inpainting of task-specific masks as an auxiliary task to enhance ML-based individual identification from animal skin patterns. We propose a comparative analysis among four models as an encoder backbone for the individual identification task. We focus on the case study of zebrafish, which is a widely recognized biological model organism, and which exhibits individually identifying skin patterns. To evaluate encoder backbone performance, we present standard metrics for classification accuracy, embedding clustering metrics, and GradCAM visualizations.

Attention-Based Chaotic Self-Supervision for Medical Image Classification

Deep learning models for medical image classification usually achieve promising results but typically rely on large, annotated datasets or standard transfer learning from ImageNet. Self-Supervised Learning (SSL) has emerged as a powerful alternative, yet common methods like masked autoencoders (MAEs) may inadvertently destroy fine-grained diagnostic features by using random masking. In this paper, we propose a novel SSL pre-training strategy, the Chaotic Denoising Autoencoder (CDAE). Instead of masking, we apply a chaotic transformation to the input image, tasking an autoencoder to reconstruct the original. We hypothesize this forces the encoder to learn robust, domain-specific features by "inverting the chaos". Furthermore, we propose an attentive fusion mechanism that combines features from our CDAE-trained encoder with a standard encoder, leveraging the strengths of both general and domain-specific representations. Our method is evaluated on two public medical datasets: ISIC 2018 (skin lesions) and APTOS 2019 (diabetic retinopathy). The proposed model achieves high performance, with an accuracy of 0.9221 and an F1-macro of 0.8530 on ISIC 2018, and an accuracy of 0.8644 and F1-macro of 0.7433 on APTOS 2019, demonstrating the efficacy of our approach.

Optimize-at-Capture: Highly-adaptive Exposure Controlling for In-Vehicle Non-contact Heart-rate Monitoring

Remote photoplethysmography (rPPG) holds great promise for continuous heart-rate monitoring of drivers in intelligent vehicles. However, its performance is severely degraded by the highly dynamic illumination changes. A critical yet overlooked factor is the lack of exposure controlling during video acquisition -- most existing systems rely on either fixed exposure settings or camera build-in auto-exposure, both of which fail to maintain stable facial brightness under rapidly changing lighting conditions during driving. To address this gap, we propose a highly-adaptive exposure controlling framework that proactively adjusts exposure parameters based on predictive modeling of historical skin reflections. Unlike standard auto-exposure, our method is specifically optimized for rPPG measurement, ensuring the skin region of interest (ROI) remains within the optimal dynamic range for rPPG signal extraction. As an important contribution of this study, we introduce ExpDrive, a public in-vehicle physiological monitoring dataset comprising synchronized facial video and reference ECG from 48 subjects captured under real driving conditions. Extensive experiments demonstrate that our method consistently outperforms fixed exposure and standard auto-exposure strategies. Specifically, it reduces the Mean Absolute Error (MAE) by 6.31 bpm (from 14.1 to 7.79 bpm) and significantly increases the success rate by 32.3 percentage points (p < 0.001) (from 24.9% to 57.2%) across challenging driving scenarios. Notably, it clearly improved the performance of non-contact heart-rate monitoring in both low-light (rainy) and high-glare (sunny) conditions, validating the efficacy of exposure-aware acquisition design.

SIAM: Head and Brain MRI Segmentation from Few High-Quality Templates via Synthetic Training

Synthetic training has recently advanced brain MRI segmentation by enabling contrast-agnostic models trained entirely on generated data. However, most existing approaches rely on hundreds of automatically labeled templates, introducing systematic biases and limiting their flexibility to incorporate new anatomical structures. We present the Segment It All Model (SIAM), a 3D whole-head segmentation framework for 16 anatomical structures, trained using only six high-quality, manually annotated templates. SIAM extends domain randomization to both intensity and shape domains: synthetic image generation ensures contrast variability, while high-resolution spatial transformations model anatomical differences in cortical thickness and deep nuclei morphology. Unlike prior synthetic models, SIAM simultaneously segments brain as well as extra-cerebral tissues, including cerebrospinal fluid, vessels, dura mater, skull, and skin, enabling fully automated, preprocessing-free analysis. Evaluation across eight heterogeneous datasets (N=301), that include multiple contrasts (T1-weighted, T2-weighted, CT) and span a wide range of ages, demonstrates that SIAM matches or outperforms state-of-the-art methods for brain structures, in addition to extending automated segmentation to non-brain structures. The model also exhibits superior consistency across contrasts and repeated acquisitions, together with improved sensitivity to subtle gray matter atrophy. We openly release the model and the label templates at https://github.com/romainVala/SIAM.

Improving Model Safety by Targeted Error Correction

The widespread adoption of machine learning in critical applications demands techniques to mitigate high-consequence errors. Our method utilizes a dual-classifier GBDT pipeline to distinguish routine human-like errors from high-risk non-human misclassifications. Evaluated across three domains, animal breed classification, skin lesion diagnosis (ISIC 2018), and prostate histopathology (SICAPv2), our framework demonstrates robust safety improvements. To address real-world deployment concerns, our results confirm the pipeline introduces negligible inference latency (1.60% overhead for the animal dataset, 1.84% for ISIC, and 1.70% for SICAPv2) while outperforming traditional Maximum Class Probability (MCP) baselines in correction precision. Our conservative correction strategy successfully reduced dangerous non-human errors by 34.1% in ISIC and 12.57% in SICAPv2, improving super-class diagnostic safety to 90.41% and 92.13% respectively. This proves that safety-critical reliability can be substantially enhanced post-hoc without expensive model retraining. keywords: Error Analysis, Post-hoc Correction, Trustworthy AI.