Addressing Bias in VLMs for Glaucoma Detection Without Protected Attribute Supervision

Vision-Language Models (VLMs) have achieved remarkable success on multimodal tasks such as image-text retrieval and zero-shot classification, yet they can exhibit demographic biases even when explicit protected attributes are absent during training. In this work, we focus on automated glaucoma screening from retinal fundus images, a critical application given that glaucoma is a leading cause of irreversible blindness and disproportionately affects underserved populations. Building on a reweighting-based contrastive learning framework, we introduce an attribute-agnostic debiasing method that (i) infers proxy subgroups via unsupervised clustering of image-image embeddings, (ii) computes gradient-similarity weights between the CLIP-style multimodal loss and a SimCLR-style image-pair contrastive loss, and (iii) applies these weights in a joint, top-$k$ weighted objective to upweight underperforming clusters. This label-free approach adaptively targets the hardest examples, thereby reducing subgroup disparities. We evaluate our method on the Harvard FairVLMed glaucoma subset, reporting Equalized Odds Distance (EOD), Equalized Subgroup AUC (ES AUC), and Groupwise AUC to demonstrate equitable performance across inferred demographic subgroups.

Probabilistic Variational Contrastive Learning

Deterministic embeddings learned by contrastive learning (CL) methods such as SimCLR and SupCon achieve state-of-the-art performance but lack a principled mechanism for uncertainty quantification. We propose Variational Contrastive Learning (VCL), a decoder-free framework that maximizes the evidence lower bound (ELBO) by interpreting the InfoNCE loss as a surrogate reconstruction term and adding a KL divergence regularizer to a uniform prior on the unit hypersphere. We model the approximate posterior $q_\theta(z|x)$ as a projected normal distribution, enabling the sampling of probabilistic embeddings. Our two instantiations--VSimCLR and VSupCon--replace deterministic embeddings with samples from $q_\theta(z|x)$ and incorporate a normalized KL term into the loss. Experiments on multiple benchmarks demonstrate that VCL mitigates dimensional collapse, enhances mutual information with class labels, and matches or outperforms deterministic baselines in classification accuracy, all the while providing meaningful uncertainty estimates through the posterior model. VCL thus equips contrastive learning with a probabilistic foundation, serving as a new basis for contrastive approaches.

scSSL-Bench: Benchmarking Self-Supervised Learning for Single-Cell Data

Self-supervised learning (SSL) has proven to be a powerful approach for extracting biologically meaningful representations from single-cell data. To advance our understanding of SSL methods applied to single-cell data, we present scSSL-Bench, a comprehensive benchmark that evaluates nineteen SSL methods. Our evaluation spans nine datasets and focuses on three common downstream tasks: batch correction, cell type annotation, and missing modality prediction. Furthermore, we systematically assess various data augmentation strategies. Our analysis reveals task-specific trade-offs: the specialized single-cell frameworks, scVI, CLAIRE, and the finetuned scGPT excel at uni-modal batch correction, while generic SSL methods, such as VICReg and SimCLR, demonstrate superior performance in cell typing and multi-modal data integration. Random masking emerges as the most effective augmentation technique across all tasks, surpassing domain-specific augmentations. Notably, our results indicate the need for a specialized single-cell multi-modal data integration framework. scSSL-Bench provides a standardized evaluation platform and concrete recommendations for applying SSL to single-cell analysis, advancing the convergence of deep learning and single-cell genomics.

Circumventing Backdoor Space via Weight Symmetry

Deep neural networks are vulnerable to backdoor attacks, where malicious behaviors are implanted during training. While existing defenses can effectively purify compromised models, they typically require labeled data or specific training procedures, making them difficult to apply beyond supervised learning settings. Notably, recent studies have shown successful backdoor attacks across various learning paradigms, highlighting a critical security concern. To address this gap, we propose Two-stage Symmetry Connectivity (TSC), a novel backdoor purification defense that operates independently of data format and requires only a small fraction of clean samples. Through theoretical analysis, we prove that by leveraging permutation invariance in neural networks and quadratic mode connectivity, TSC amplifies the loss on poisoned samples while maintaining bounded clean accuracy. Experiments demonstrate that TSC achieves robust performance comparable to state-of-the-art methods in supervised learning scenarios. Furthermore, TSC generalizes to self-supervised learning frameworks, such as SimCLR and CLIP, maintaining its strong defense capabilities. Our code is available at https://github.com/JiePeng104/TSC.

An Interpretable Representation Learning Approach for Diffusion Tensor Imaging

Diffusion Tensor Imaging (DTI) tractography offers detailed insights into the structural connectivity of the brain, but presents challenges in effective representation and interpretation in deep learning models. In this work, we propose a novel 2D representation of DTI tractography that encodes tract-level fractional anisotropy (FA) values into a 9x9 grayscale image. This representation is processed through a Beta-Total Correlation Variational Autoencoder with a Spatial Broadcast Decoder to learn a disentangled and interpretable latent embedding. We evaluate the quality of this embedding using supervised and unsupervised representation learning strategies, including auxiliary classification, triplet loss, and SimCLR-based contrastive learning. Compared to the 1D Group deep neural network (DNN) baselines, our approach improves the F1 score in a downstream sex classification task by 15.74% and shows a better disentanglement than the 3D representation.

SSPS: Self-Supervised Positive Sampling for Robust Self-Supervised Speaker Verification

Self-Supervised Learning (SSL) has led to considerable progress in Speaker Verification (SV). The standard framework uses same-utterance positive sampling and data-augmentation to generate anchor-positive pairs of the same speaker. This is a major limitation, as this strategy primarily encodes channel information from the recording condition, shared by the anchor and positive. We propose a new positive sampling technique to address this bottleneck: Self-Supervised Positive Sampling (SSPS). For a given anchor, SSPS aims to find an appropriate positive, i.e., of the same speaker identity but a different recording condition, in the latent space using clustering assignments and a memory queue of positive embeddings. SSPS improves SV performance for both SimCLR and DINO, reaching 2.57% and 2.53% EER, outperforming SOTA SSL methods on VoxCeleb1-O. In particular, SimCLR-SSPS achieves a 58% EER reduction by lowering intra-speaker variance, providing comparable performance to DINO-SSPS.

Representation Learning via Non-Contrastive Mutual Information

Labeling data is often very time consuming and expensive, leaving us with a majority of unlabeled data. Self-supervised representation learning methods such as SimCLR (Chen et al., 2020) or BYOL (Grill et al., 2020) have been very successful at learning meaningful latent representations from unlabeled image data, resulting in much more general and transferable representations for downstream tasks. Broadly, self-supervised methods fall into two types: 1) Contrastive methods, such as SimCLR; and 2) Non-Contrastive methods, such as BYOL. Contrastive methods are generally trying to maximize mutual information between related data points, so they need to compare every data point to every other data point, resulting in high variance, and thus requiring large batch sizes to work well. Non-contrastive methods like BYOL have much lower variance as they do not need to make pairwise comparisons, but are much trickier to implement as they have the possibility of collapsing to a constant vector. In this paper, we aim to develop a self-supervised objective that combines the strength of both types. We start with a particular contrastive method called the Spectral Contrastive Loss (HaoChen et al., 2021; Lu et al., 2024), and we convert it into a more general non-contrastive form; this removes the pairwise comparisons resulting in lower variance, but keeps the mutual information formulation of the contrastive method preventing collapse. We call our new objective the Mutual Information Non-Contrastive (MINC) loss. We test MINC by learning image representations on ImageNet (similar to SimCLR and BYOL) and show that it consistently improves upon the Spectral Contrastive loss baseline.

Impact of Language Guidance: A Reproducibility Study

Modern deep-learning architectures need large amounts of data to produce state-of-the-art results. Annotating such huge datasets is time-consuming, expensive, and prone to human error. Recent advances in self-supervised learning allow us to train huge models without explicit annotation. Contrastive learning is a popular paradigm in self-supervised learning. Recent works like SimCLR and CLIP rely on image augmentations or directly minimizing cross-modal loss between image and text. Banani et al. (2023) propose to use language guidance to sample view pairs. They claim that language enables better conceptual similarity, eliminating the effects of visual variability. We reproduce their experiments to verify their claims and find that their dataset, RedCaps, contains low-quality captions. We use an off-the-shelf image captioning model, BLIP-2, to replace the captions and improve performance, and we also devise a new metric to evaluate the semantic capabilities of self-supervised models based on interpretability methods.

Efficient Building Roof Type Classification: A Domain-Specific Self-Supervised Approach

Accurate classification of building roof types from aerial imagery is crucial for various remote sensing applications, including urban planning, disaster management, and infrastructure monitoring. However, this task is often hindered by the limited availability of labeled data for supervised learning approaches. To address this challenge, this paper investigates the effectiveness of self supervised learning with EfficientNet architectures, known for their computational efficiency, for building roof type classification. We propose a novel framework that incorporates a Convolutional Block Attention Module (CBAM) to enhance the feature extraction capabilities of EfficientNet. Furthermore, we explore the benefits of pretraining on a domain-specific dataset, the Aerial Image Dataset (AID), compared to ImageNet pretraining. Our experimental results demonstrate the superiority of our approach. Employing Simple Framework for Contrastive Learning of Visual Representations (SimCLR) with EfficientNet-B3 and CBAM achieves a 95.5% accuracy on our validation set, matching the performance of state-of-the-art transformer-based models while utilizing significantly fewer parameters. We also provide a comprehensive evaluation on two challenging test sets, demonstrating the generalization capability of our method. Notably, our findings highlight the effectiveness of domain-specific pretraining, consistently leading to higher accuracy compared to models pretrained on the generic ImageNet dataset. Our work establishes EfficientNet based self-supervised learning as a computationally efficient and highly effective approach for building roof type classification, particularly beneficial in scenarios with limited labeled data.

Unsupervised Detection of Fraudulent Transactions in E-commerce Using Contrastive Learning

With the rapid development of e-commerce, e-commerce platforms are facing an increasing number of fraud threats. Effectively identifying and preventing these fraudulent activities has become a critical research problem. Traditional fraud detection methods typically rely on supervised learning, which requires large amounts of labeled data. However, such data is often difficult to obtain, and the continuous evolution of fraudulent activities further reduces the adaptability and effectiveness of traditional methods. To address this issue, this study proposes an unsupervised e-commerce fraud detection algorithm based on SimCLR. The algorithm leverages the contrastive learning framework to effectively detect fraud by learning the underlying representations of transaction data in an unlabeled setting. Experimental results on the eBay platform dataset show that the proposed algorithm outperforms traditional unsupervised methods such as K-means, Isolation Forest, and Autoencoders in terms of accuracy, precision, recall, and F1 score, demonstrating strong fraud detection capabilities. The results confirm that the SimCLR-based unsupervised fraud detection method has broad application prospects in e-commerce platform security, improving both detection accuracy and robustness. In the future, with the increasing scale and diversity of datasets, the model's performance will continue to improve, and it could be integrated with real-time monitoring systems to provide more efficient security for e-commerce platforms.