Beyond MACs: Hardware Efficient Architecture Design for Vision Backbones

Vision backbone networks play a central role in modern computer vision. Enhancing their efficiency directly benefits a wide range of downstream applications. To measure efficiency, many publications rely on MACs (Multiply Accumulate operations) as a predictor of execution time. In this paper, we experimentally demonstrate the shortcomings of such a metric, especially in the context of edge devices. By contrasting the MAC count and execution time of common architectural design elements, we identify key factors for efficient execution and provide insights to optimize backbone design. Based on these insights, we present LowFormer, a novel vision backbone family. LowFormer features a streamlined macro and micro design that includes Lowtention, a lightweight alternative to Multi-Head Self-Attention. Lowtention not only proves more efficient, but also enables superior results on ImageNet. Additionally, we present an edge GPU version of LowFormer, that can further improve upon its baseline's speed on edge GPU and desktop GPU. We demonstrate LowFormer's wide applicability by evaluating it on smaller image classification datasets, as well as adapting it to several downstream tasks, such as object detection, semantic segmentation, image retrieval, and visual object tracking. LowFormer models consistently achieve remarkable speed-ups across various hardware platforms compared to recent state-of-the-art backbones. Code and models are available at https://github.com/altair199797/LowFormer/blob/main/Beyond_MACs.md.

Development of a European Union Time-Indexed Reference Dataset for Assessing the Performance of Signal Detection Methods in Pharmacovigilance using a Large Language Model

Background: The identification of optimal signal detection methods is hindered by the lack of reliable reference datasets. Existing datasets do not capture when adverse events (AEs) are officially recognized by regulatory authorities, preventing restriction of analyses to pre-confirmation periods and limiting evaluation of early detection performance. This study addresses this gap by developing a time-indexed reference dataset for the European Union (EU), incorporating the timing of AE inclusion in product labels along with regulatory metadata. Methods: Current and historical Summaries of Product Characteristics (SmPCs) for all centrally authorized products (n=1,513) were retrieved from the EU Union Register of Medicinal Products (data lock: 15 December 2025). Section 4.8 was extracted and processed using DeepSeek V3 to identify AEs. Regulatory metadata, including labelling changes, were programmatically extracted. Time indexing was based on the date of AE inclusion in the SmPC. Results: The database includes 17,763 SmPC versions spanning 1995-2025, comprising 125,026 drug-AE associations. The time-indexed reference dataset, restricted to active products, included 1,479 medicinal products and 110,823 drug-AE associations. Most AEs were identified pre-marketing (74.5%) versus post-marketing (25.5%). Safety updates peaked around 2012. Gastrointestinal, skin, and nervous system disorders were the most represented System Organ Classes. Drugs had a median of 48 AEs across 14 SOCs. Conclusions: The proposed dataset addresses a critical gap in pharmacovigilance by incorporating temporal information on AE recognition for the EU, supporting more accurate assessment of signal detection performance and facilitating methodological comparisons across analytical approaches.

The Multi-AMR Buffer Storage, Retrieval, and Reshuffling Problem: Exact and Heuristic Approaches

Buffer zones are essential in production systems to decouple sequential processes. In dense floor storage environments, such as space-constrained brownfield facilities, manual operation is increasingly challenged by severe labor shortages and rising operational costs. Automating these zones requires solving the Buffer Storage, Retrieval, and Reshuffling Problem (BSRRP). While previous work has addressed scenarios where the focus is limited to reshuffling and retrieving a fixed set of items, real-world manufacturing necessitates an adaptive approach that also incorporates arriving unit loads. This paper introduces the Multi-AMR BSRRP, coordinating a robot fleet to manage concurrent reshuffling, alongside time-windowed storage and retrieval tasks, within a shared floor area. We formulate a Binary Integer Programming (IP) model to obtain exact solutions for benchmarking purposes. As the problem is NP-hard, rendering exact methods computationally intractable for industrial scales, we propose a hierarchical heuristic. This approach decomposes the problem into an A* search for task-level sequence planning of unit load placements, and a Constraint Programming (CP) approach for multi-robot coordination and scheduling. Experiments demonstrate orders-of-magnitude computation time reductions compared to the exact formulation. These results confirm the heuristic's viability as responsive control logic for high-density production environments.

CADSmith: Multi-Agent CAD Generation with Programmatic Geometric Validation

Existing methods for text-to-CAD generation either operate in a single pass with no geometric verification or rely on lossy visual feedback that cannot resolve dimensional errors. We present CADSmith, a multi-agent pipeline that generates CadQuery code from natural language. It then undergoes an iterative refinement process through two nested correction loops: an inner loop that resolves execution errors and an outer loop grounded in programmatic geometric validation. The outer loop combines exact measurements from the OpenCASCADE kernel (bounding box dimensions, volume, solid validity) with holistic visual assessment from an independent vision-language model Judge. This provides both the numerical precision and the high-level shape awareness needed to converge on the correct geometry. The system uses retrieval-augmented generation over API documentation rather than fine-tuning, maintaining a current database as the underlying CAD library evolves. We evaluate on a custom benchmark of 100 prompts in three difficulty tiers (T1 through T3) with three ablation configurations. Against a zero-shot baseline, CADSmith achieves a 100% execution rate (up from 95%), improves the median F1 score from 0.9707 to 0.9846, the median IoU from 0.8085 to 0.9629, and reduces the mean Chamfer Distance from 28.37 to 0.74, demonstrating that closed-loop refinement with programmatic geometric feedback substantially improves the quality and reliability of LLM-generated CAD models.

Automating Clinical Information Retrieval from Finnish Electronic Health Records Using Large Language Models

Clinicians often need to retrieve patient-specific information from electronic health records (EHRs), a task that is time-consuming and error-prone. We present a locally deployable Clinical Contextual Question Answering (CCQA) framework that answers clinical questions directly from EHRs without external data transfer. Open-source large language models (LLMs) ranging from 4B to 70B parameters were benchmarked under fully offline conditions using 1,664 expert-annotated question-answer pairs derived from records of 183 patients. The dataset consisted predominantly of Finnish clinical text. In free-text generation, Llama-3.1-70B achieved 95.3% accuracy and 97.3% consistency across semantically equivalent question variants, while the smaller Qwen3-30B-A3B-2507 model achieved comparable performance. In a multiple-choice setting, models showed similar accuracy but variable calibration. Low-precision quantization (4-bit and 8-bit) preserved predictive performance while reducing GPU memory requirements and improving deployment feasibility. Clinical evaluation identified clinically significant errors in 2.9% of outputs, and semantically equivalent questions occasionally yielded discordant responses, including instances where one formulation was correct and the other contained a clinically significant error (0.96% of cases). These findings demonstrate that locally hosted open-source LLMs can accurately retrieve patient-specific information from EHRs using natural-language queries, while highlighting the need for validation and human oversight in clinical deployment.

HINT: Composed Image Retrieval with Dual-path Compositional Contextualized Network

Composed Image Retrieval (CIR) is a challenging image retrieval paradigm. It aims to retrieve target images from large-scale image databases that are consistent with the modification semantics, based on a multimodal query composed of a reference image and modification text. Although existing methods have made significant progress in cross-modal alignment and feature fusion, a key flaw remains: the neglect of contextual information in discriminating matching samples. However, addressing this limitation is not an easy task due to two challenges: 1) implicit dependencies and 2) the lack of a differential amplification mechanism. To address these challenges, we propose a dual-patH composItional coNtextualized neTwork (HINT), which can perform contextualized encoding and amplify the similarity differences between matching and non-matching samples, thus improving the upper performance of CIR models in complex scenarios. Our HINT model achieves optimal performance on all metrics across two CIR benchmark datasets, demonstrating the superiority of our HINT model. Codes are available at https://github.com/zh-mingyu/HINT.

ClinicalAgents: Multi-Agent Orchestration for Clinical Decision Making with Dual-Memory

While Large Language Models (LLMs) have demonstrated potential in healthcare, they often struggle with the complex, non-linear reasoning required for accurate clinical diagnosis. Existing methods typically rely on static, linear mappings from symptoms to diagnoses, failing to capture the iterative, hypothesis-driven reasoning inherent to human clinicians. To bridge this gap, we introduce ClinicalAgents, a novel multi-agent framework designed to simulate the cognitive workflow of expert clinicians. Unlike rigid sequential chains, ClinicalAgents employs a dynamic orchestration mechanism modeled as a Monte Carlo Tree Search (MCTS) process. This allows an Orchestrator to iteratively generate hypotheses, actively verify evidence, and trigger backtracking when critical information is missing. Central to this framework is a Dual-Memory architecture: a mutable Working Memory that maintains the evolving patient state for context-aware reasoning, and a static Experience Memory that retrieves clinical guidelines and historical cases via an active feedback loop. Extensive experiments demonstrate that ClinicalAgents achieves state-of-the-art performance, significantly enhancing both diagnostic accuracy and explainability compared to strong single-agent and multi-agent baselines.

Retrieval-Augmented Generation Based Nurse Observation Extraction

Recent advancements in Large Language Models (LLMs) have played a significant role in reducing human workload across various domains, a trend that is increasingly extending into the medical field. In this paper, we propose an automated pipeline designed to alleviate the burden on nurses by automatically extracting clinical observations from nurse dictations. To ensure accurate extraction, we introduce a method based on Retrieval-Augmented Generation (RAG). Our approach demonstrates effective performance, achieving an F1-score of 0.796 on the MEDIQA-SYNUR test dataset.

GLU: Global-Local-Uncertainty Fusion for Scalable Spatiotemporal Reconstruction and Forecasting

Digital twins of complex physical systems are expected to infer unobserved states from sparse measurements and predict their evolution in time, yet these two functions are typically treated as separate tasks. Here we present GLU, a Global-Local-Uncertainty framework that formulates sparse reconstruction and dynamic forecasting as a unified state-representation problem and introduces a structured latent assembly to both tasks. The central idea is to build a structured latent state that combines a global summary of system-level organization, local tokens anchored to available measurements, and an uncertainty-driven importance field that weights observations according to the physical informativeness. For reconstruction, GLU uses importance-aware adaptive neighborhood selection to retrieve locally relevant information while preserving global consistency and allowing flexible query resolution on arbitrary geometries. Across a suite of challenging benchmarks, GLU consistently improves reconstruction fidelity over reduced-order, convolutional, neural operator, and attention-based baselines, better preserving multi-scale structures. For forecasting, a hierarchical Leader-Follower Dynamics module evolves the latent state with substantially reduced memory growth, maintains stable rollout behavior and delays error accumulation in nonlinear dynamics. On a realistic turbulent combustion dataset, it further preserves not only sharp fronts and broadband structures in multiple physical fields, but also their cross-channel thermo-chemical couplings. Scalability tests show that these gains are achieved with substantially lower memory growth than comparable attention-based baselines. Together, these results establish GLU as a flexible and computationally practical paradigm for sparse digital twins.

HolisticSemGes: Semantic Grounding of Holistic Co-Speech Gesture Generation with Contrastive Flow-Matching

While the field of co-speech gesture generation has seen significant advances, producing holistic, semantically grounded gestures remains a challenge. Existing approaches rely on external semantic retrieval methods, which limit their generalisation capability due to dependency on predefined linguistic rules. Flow-matching-based methods produce promising results; however, the network is optimised using only semantically congruent samples without exposure to negative examples, leading to learning rhythmic gestures rather than sparse motion, such as iconic and metaphoric gestures. Furthermore, by modelling body parts in isolation, the majority of methods fail to maintain crossmodal consistency. We introduce a Contrastive Flow Matching-based co-speech gesture generation model that uses mismatched audio-text conditions as negatives, training the velocity field to follow the correct motion trajectory while repelling semantically incongruent trajectories. Our model ensures cross-modal coherence by embedding text, audio, and holistic motion into a composite latent space via cosine and contrastive objectives. Extensive experiments and a user study demonstrate that our proposed approach outperforms state-of-the-art methods on two datasets, BEAT2 and SHOW.