Local life service is a vital scenario in Kuaishou App, where video recommendation is intrinsically linked with store's location information. Thus, recommendation in our scenario is challenging because we should take into account user's interest and real-time location at the same time. In the face of such complex scenarios, end-to-end generative recommendation has emerged as a new paradigm, such as OneRec in the short video scenario, OneSug in the search scenario, and EGA in the advertising scenario. However, in local life service, an end-to-end generative recommendation model has not yet been developed as there are some key challenges to be solved. The first challenge is how to make full use of geographic information. The second challenge is how to balance multiple objectives, including user interests, the distance between user and stores, and some other business objectives. To address the challenges, we propose OneLoc. Specifically, we leverage geographic information from different perspectives: (1) geo-aware semantic ID incorporates both video and geographic information for tokenization, (2) geo-aware self-attention in the encoder leverages both video location similarity and user's real-time location, and (3) neighbor-aware prompt captures rich context information surrounding users for generation. To balance multiple objectives, we use reinforcement learning and propose two reward functions, i.e., geographic reward and GMV reward. With the above design, OneLoc achieves outstanding offline and online performance. In fact, OneLoc has been deployed in local life service of Kuaishou App. It serves 400 million active users daily, achieving 21.016% and 17.891% improvements in terms of gross merchandise value (GMV) and orders numbers.