DeformX: A Versatile Co-Simulation Framework for Deformable Linear Objects

Deformable linear objects (DLOs) such as wires, cables, and ropes are common in robotic manipulation tasks, yet simulating them with both visual realism and physical accuracy remains challenging. Existing visual simulation methods typically rely on procedural geometric primitives that lack physically grounded deformation behavior, while physics-based approaches with robot learning support often approximate DLOs as rigid-link chains or generic soft bodies, failing to accurately capture the bending, twisting, and shear mechanics of slender elastic structures. In this work, we introduce DeformX, a co-simulation framework that integrates a dedicated Cosserat rod physics engine with NVIDIA Isaac Sim, enabling DLO simulations that are both physically faithful and visually realistic. Our Cosserat rod engine simulates the dynamics and self-collisions of DLOs, and contact interactions with arbitrary free-form meshes. To achieve high-fidelity visualization, we employ mesh skinning to map discrete rod deformations onto imported CAD models. To the best of our knowledge, DeformX is the one of the first frameworks for DLO simulation that unifies realistic visualization, principled physics, and compatibility with robot learning pipelines. We demonstrate its versatility across synthetic data generation and policy learning for DLO manipulation, and validate visual and physical fidelity through comparisons against real-world experiments. Notably, fine-tuning Segment Anything Model 3 (SAM3) on DeformX-generated data yields a 10.2% mAP@75 improvement in real-image wire segmentation, and a rope-swinging policy trained entirely in DeformX achieves a mean target-hitting error of 6.6 cm on a UR5e manipulator in real-world trials, highlighting its strong sim-to-real transfer capability.

Bridging Large Language Models and Single-Cell Transcriptomics in Dissecting Selective Motor Neuron Vulnerability

Understanding cell identity and function through single-cell level sequencing data remains a key challenge in computational biology. We present a novel framework that leverages gene-specific textual annotations from the NCBI Gene database to generate biologically contextualized cell embeddings. For each cell in a single-cell RNA sequencing (scRNA-seq) dataset, we rank genes by expression level, retrieve their NCBI Gene descriptions, and transform these descriptions into vector embedding representations using large language models (LLMs). The models used include OpenAI text-embedding-ada-002, text-embedding-3-small, and text-embedding-3-large (Jan 2024), as well as domain-specific models BioBERT and SciBERT. Embeddings are computed via an expression-weighted average across the top N most highly expressed genes in each cell, providing a compact, semantically rich representation. This multimodal strategy bridges structured biological data with state-of-the-art language modeling, enabling more interpretable downstream applications such as cell-type clustering, cell vulnerability dissection, and trajectory inference.

A Language Anchor-Guided Method for Robust Noisy Domain Generalization

Real-world machine learning applications often struggle with two major challenges: distribution shift and label noise. Models tend to overfit by focusing on redundant and uninformative features in the training data, which makes it hard for them to generalize to the target domain. Noisy data worsens this problem by causing further overfitting to the noise, meaning that existing methods often fail to tell the difference between true, invariant features and misleading, spurious ones. To tackle these issues, we introduce Anchor Alignment and Adaptive Weighting (A3W). This new algorithm uses sample reweighting guided by natural language processing (NLP) anchors to extract more representative features. In simple terms, A3W leverages semantic representations from natural language models as a source of domain-invariant prior knowledge. Additionally, it employs a weighted loss function that adjusts each sample's contribution based on its similarity to the corresponding NLP anchor. This adjustment makes the model more robust to noisy labels. Extensive experiments on standard benchmark datasets show that A3W consistently outperforms state-of-the-art domain generalization methods, offering significant improvements in both accuracy and robustness across different datasets and noise levels.

Vision-based FDM Printing for Fabricating Airtight Soft Actuators

Pneumatic soft robots are typically fabricated by molding, a manual fabrication process that requires skilled labor. Additive manufacturing has the potential to break this limitation and speed up the fabrication process but struggles with consistently producing high-quality prints. We propose a low-cost approach to improve the print quality of desktop fused deposition modeling by adding a webcam to the printer to monitor the printing process and detect and correct defects such as holes or gaps. We demonstrate that our approach improves the air-tightness of printed pneumatic actuators without fine-tuning printing parameters. Our approach presents a new option for robustly fabricating airtight, soft robotic actuators.