Weak Collocation Regression method: fast reveal hidden stochastic dynamics from high-dimensional aggregate data

Revealing hidden dynamics from the stochastic data is a challenging problem as randomness takes part in the evolution of the data. The problem becomes exceedingly complex when the trajectories of the stochastic data are absent in many scenarios. Here we present an approach to effectively modeling the dynamics of the stochastic data without trajectories based on the weak form of the Fokker-Planck (FP) equation, which governs the evolution of the density function in the Brownian process. Taking the collocations of Gaussian functions as the test functions in the weak form of the FP equation, we transfer the derivatives to the Gaussian functions and thus approximate the weak form by the expectational sum of the data. With a dictionary representation of the unknown terms, a linear system is built and then solved by the regression, revealing the unknown dynamics of the data. Hence, we name the method with the Weak Collocation Regression (WCR) method for its three key components: weak form, collocation of Gaussian kernels, and regression. The numerical experiments show that our method is flexible and fast, which reveals the dynamics within seconds in multi-dimensional problems and can be easily extended to high-dimensional data such as 20 dimensions. WCR can also correctly identify the hidden dynamics of the complex tasks with variable-dependent diffusion and coupled drift, and the performance is robust, achieving high accuracy in the case with noise added.

A Deep Learning Approach to Predicting Ventilator Parameters for Mechanically Ventilated Septic Patients

We develop a deep learning approach to predicting a set of ventilator parameters for a mechanically ventilated septic patient using a long and short term memory (LSTM) recurrent neural network (RNN) model. We focus on short-term predictions of a set of ventilator parameters for the septic patient in emergency intensive care unit (EICU). The short-term predictability of the model provides attending physicians with early warnings to make timely adjustment to the treatment of the patient in the EICU. The patient specific deep learning model can be trained on any given critically ill patient, making it an intelligent aide for physicians to use in emergent medical situations.