PertMind: Eliciting Emergent Biological Reasoning in LLM via Reinforcement Learning on Cellular Perturbation Data

Large language models can describe mechanisms, yet scalable post-training still depends on costly, manually curated biological reasoning traces. Here we show that cellular perturbation atlases can instead become reinforcement-learning environments, where measured gene responses provide computable rewards for biological reasoning. We introduce PertMind, which combines trusted-trajectory supervised initialization with gene-, pathway-, and format-level reinforcement signals. Trained only on forward perturbation-response prediction, PertMind improved response inference in unseen cellular contexts while retaining general language capabilities. It also transferred without task-specific post-training to reverse perturbation identification, double-perturbation reasoning, phenotypic-screen prioritization, and biological-process interpretation. PertMind further generated biological profiles that supported competitive gene, cell, and donor representations across multiscale downstream tasks. These results support the hypothesis that reinforcement on experimental endpoints can concentrate reusable biological strategies already accessible to pretrained models. More broadly, perturbation-derived reinforcement learning offers a scalable route for transforming expanding experimental atlases into training environments for general-purpose biological reasoning.

MoP-JEPA: Hard-Assigned Predictor Mixtures for Stochastic JEPA World Models

JEPA world models predict the next latent state with a single deterministic predictor trained by latent regression. We show that this fails structurally when the environment is stochastic: at a branching transition, the regression-optimal predictor outputs the conditional mean of the successor embeddings, a point between the true next states that corresponds to no state at all. We prove this collapse for deterministic and gated mixture-of-experts predictors, and prove that MoP-JEPA's hard-assigned predictors converge instead to a quantizer of the transition distribution: one head per successor mode, enumerable in a single forward pass, which is the interface a planner consumes. On official OGBench offline data with leak-free evaluation, planning over single-predictor rollouts performs poorly ($0.02$--$0.09$ success) while planning over our predicted modes reaches up to $0.85$, ahead of deterministic, gated-MoE, and variational predictors on every task. Because multi-prediction evaluation invites coverage freeloading, a verification protocol is part of the method: an input-agnostic codebook control, a shuffled-context test, router-gated readouts, transition-precision guards, and a verified-route criterion in which the model proposes its transition graph blind and ground truth is used only to check the result. Under this criterion our method outperforms the strongest soft alternative on all three mazes ($2$--$5\times$), and the protocol identifies the remaining gap in that baseline's raw scores as routes through predicted transitions that do not exist. The same model executes in the real environment, placing second of seven against the published OGBench baselines on the hardest maze. Multimodal dynamics decide whether a JEPA world model can plan at all; a mixture of predictors with hard assignment is a minimal and verifiable fix.

UnityShots: Memory-Driven Multi-Shot Audio-Video Generation with Boundary-Aware Gating

Generating a coherent multi-shot video requires structured cross-shot memory. Subject appearance, scene context, and speaker identity must persist across cuts. Existing approaches either train end-to-end over fixed-length sequences and cannot scale, generate shot-by-shot with memory banks that grow linearly, or orchestrate pretrained generators under an LLM planner without a multi-shot-aware backbone. We present UnityShots, a memory-driven multi-shot audio-video generation system built on LTX-2.3, trained on annotated cinematic and music-video shots. The video stream maintains two fixed-size slots, a long-term memory (LTM) slot anchored to the opening shot and a short-term memory (STM) slot holding the immediately preceding tail, both updated at every cut by a boundary-conditioned gate that fuses visual cut probability and beat-tracker signals. The audio stream injects a reference speaker token at every shot to preserve vocal timbre without a sliding audio bank. A discrete cut-type prior, learned through AdaLN, becomes an inference-time control knob over transition strength. We release a benchmark of $200$ multi-cultural multi-shot sequences spanning six ethnic regions and ten or more languages, with per-shot reference identities, reference audio, and per-boundary transition labels. Evaluated across I2V, T2V, and R2V conditioning modes, UnityShots leads open-source baselines on every cross-shot coherence metric and matches the strongest closed-source system on the multi-shot axes.