DSA-Tokenizer: Disentangled Semantic-Acoustic Tokenization via Flow Matching-based Hierarchical Fusion

Speech tokenizers serve as the cornerstone of discrete Speech Large Language Models (Speech LLMs). Existing tokenizers either prioritize semantic encoding, fuse semantic content with acoustic style inseparably, or achieve incomplete semantic-acoustic disentanglement. To achieve better disentanglement, we propose DSA-Tokenizer, which explicitly disentangles speech into discrete semantic and acoustic tokens via distinct optimization constraints. Specifically, semantic tokens are supervised by ASR to capture linguistic content, while acoustic tokens focus on mel-spectrograms restoration to encode style. To eliminate rigid length constraints between the two sequences, we introduce a hierarchical Flow-Matching decoder that further improve speech generation quality. Furthermore, We employ a joint reconstruction-recombination training strategy to enforce this separation. DSA-Tokenizer enables high fidelity reconstruction and flexible recombination through robust disentanglement, facilitating controllable generation in speech LLMs. Our analysis highlights disentangled tokenization as a pivotal paradigm for future speech modeling. Audio samples are avaialble at https://anonymous.4open.science/w/DSA_Tokenizer_demo/. The code and model will be made publicly available after the paper has been accepted.

Tractography with T1-weighted MRI and associated anatomical constraints on clinical quality diffusion MRI

Diffusion MRI (dMRI) streamline tractography, the gold standard for in vivo estimation of brain white matter (WM) pathways, has long been considered indicative of macroscopic relationships with WM microstructure. However, recent advances in tractography demonstrated that convolutional recurrent neural networks (CoRNN) trained with a teacher-student framework have the ability to learn and propagate streamlines directly from T1 and anatomical contexts. Training for this network has previously relied on high-resolution dMRI. In this paper, we generalize the training mechanism to traditional clinical resolution data, which allows generalizability across sensitive and susceptible study populations. We train CoRNN on a small subset of the Baltimore Longitudinal Study of Aging (BLSA), which better resembles clinical protocols. Then, we define a metric, termed the epsilon ball seeding method, to compare T1 tractography and traditional diffusion tractography at the streamline level. Under this metric, T1 tractography generated by CoRNN reproduces diffusion tractography with approximately two millimeters of error.