Diffusion Schrödinger Bridge Models for High-Quality MR-to-CT Synthesis for Head and Neck Proton Treatment Planning

In recent advancements in proton therapy, MR-based treatment planning is gaining momentum to minimize additional radiation exposure compared to traditional CT-based methods. This transition highlights the critical need for accurate MR-to-CT image synthesis, which is essential for precise proton dose calculations. Our research introduces the Diffusion Schr\"odinger Bridge Models (DSBM), an innovative approach for high-quality MR-to-CT synthesis. DSBM learns the nonlinear diffusion processes between MR and CT data distributions. This method improves upon traditional diffusion models by initiating synthesis from the prior distribution rather than the Gaussian distribution, enhancing both generation quality and efficiency. We validated the effectiveness of DSBM on a head and neck cancer dataset, demonstrating its superiority over traditional image synthesis methods through both image-level and dosimetric-level evaluations. The effectiveness of DSBM in MR-based proton treatment planning highlights its potential as a valuable tool in various clinical scenarios.

Neural Clustering based Visual Representation Learning

We investigate a fundamental aspect of machine vision: the measurement of features, by revisiting clustering, one of the most classic approaches in machine learning and data analysis. Existing visual feature extractors, including ConvNets, ViTs, and MLPs, represent an image as rectangular regions. Though prevalent, such a grid-style paradigm is built upon engineering practice and lacks explicit modeling of data distribution. In this work, we propose feature extraction with clustering (FEC), a conceptually elegant yet surprisingly ad-hoc interpretable neural clustering framework, which views feature extraction as a process of selecting representatives from data and thus automatically captures the underlying data distribution. Given an image, FEC alternates between grouping pixels into individual clusters to abstract representatives and updating the deep features of pixels with current representatives. Such an iterative working mechanism is implemented in the form of several neural layers and the final representatives can be used for downstream tasks. The cluster assignments across layers, which can be viewed and inspected by humans, make the forward process of FEC fully transparent and empower it with promising ad-hoc interpretability. Extensive experiments on various visual recognition models and tasks verify the effectiveness, generality, and interpretability of FEC. We expect this work will provoke a rethink of the current de facto grid-style paradigm.

MD-Dose: A Diffusion Model based on the Mamba for Radiotherapy Dose Prediction

Radiation therapy is crucial in cancer treatment. Experienced experts typically iteratively generate high-quality dose distribution maps, forming the basis for excellent radiation therapy plans. Therefore, automated prediction of dose distribution maps is significant in expediting the treatment process and providing a better starting point for developing radiation therapy plans. With the remarkable results of diffusion models in predicting high-frequency regions of dose distribution maps, dose prediction methods based on diffusion models have been extensively studied. However, existing methods mainly utilize CNNs or Transformers as denoising networks. CNNs lack the capture of global receptive fields, resulting in suboptimal prediction performance. Transformers excel in global modeling but face quadratic complexity with image size, resulting in significant computational overhead. To tackle these challenges, we introduce a novel diffusion model, MD-Dose, based on the Mamba architecture for predicting radiation therapy dose distribution in thoracic cancer patients. In the forward process, MD-Dose adds Gaussian noise to dose distribution maps to obtain pure noise images. In the backward process, MD-Dose utilizes a noise predictor based on the Mamba to predict the noise, ultimately outputting the dose distribution maps. Furthermore, We develop a Mamba encoder to extract structural information and integrate it into the noise predictor for localizing dose regions in the planning target volume (PTV) and organs at risk (OARs). Through extensive experiments on a dataset of 300 thoracic tumor patients, we showcase the superiority of MD-Dose in various metrics and time consumption.

Neural Graphics Primitives-based Deformable Image Registration for On-the-fly Motion Extraction

Intra-fraction motion in radiotherapy is commonly modeled using deformable image registration (DIR). However, existing methods often struggle to balance speed and accuracy, limiting their applicability in clinical scenarios. This study introduces a novel approach that harnesses Neural Graphics Primitives (NGP) to optimize the displacement vector field (DVF). Our method leverages learned primitives, processed as splats, and interpolates within space using a shallow neural network. Uniquely, it enables self-supervised optimization at an ultra-fast speed, negating the need for pre-training on extensive datasets and allowing seamless adaptation to new cases. We validated this approach on the 4D-CT lung dataset DIR-lab, achieving a target registration error (TRE) of 1.15\pm1.15 mm within a remarkable time of 1.77 seconds. Notably, our method also addresses the sliding boundary problem, a common challenge in conventional DIR methods.

Uncertainty-Aware Testing-Time Optimization for 3D Human Pose Estimation

Although data-driven methods have achieved success in 3D human pose estimation, they often suffer from domain gaps and exhibit limited generalization. In contrast, optimization-based methods excel in fine-tuning for specific cases but are generally inferior to data-driven methods in overall performance. We observe that previous optimization-based methods commonly rely on projection constraint, which only ensures alignment in 2D space, potentially leading to the overfitting problem. To address this, we propose an Uncertainty-Aware testing-time Optimization (UAO) framework, which keeps the prior information of pre-trained model and alleviates the overfitting problem using the uncertainty of joints. Specifically, during the training phase, we design an effective 2D-to-3D network for estimating the corresponding 3D pose while quantifying the uncertainty of each 3D joint. For optimization during testing, the proposed optimization framework freezes the pre-trained model and optimizes only a latent state. Projection loss is then employed to ensure the generated poses are well aligned in 2D space for high-quality optimization. Furthermore, we utilize the uncertainty of each joint to determine how much each joint is allowed for optimization. The effectiveness and superiority of the proposed framework are validated through extensive experiments on two challenging datasets: Human3.6M and MPI-INF-3DHP. Notably, our approach outperforms the previous best result by a large margin of 4.5% on Human3.6M. Our source code will be open-sourced.

ModelNet-O: A Large-Scale Synthetic Dataset for Occlusion-Aware Point Cloud Classification

Recently, 3D point cloud classification has made significant progress with the help of many datasets. However, these datasets do not reflect the incomplete nature of real-world point clouds caused by occlusion, which limits the practical application of current methods. To bridge this gap, we propose ModelNet-O, a large-scale synthetic dataset of 123,041 samples that emulate real-world point clouds with self-occlusion caused by scanning from monocular cameras. ModelNet-O is 10 times larger than existing datasets and offers more challenging cases to evaluate the robustness of existing methods. Our observation on ModelNet-O reveals that well-designed sparse structures can preserve structural information of point clouds under occlusion, motivating us to propose a robust point cloud processing method that leverages a critical point sampling (CPS) strategy in a multi-level manner. We term our method PointMLS. Through extensive experiments, we demonstrate that our PointMLS achieves state-of-the-art results on ModelNet-O and competitive results on regular datasets, and it is robust and effective. More experiments also demonstrate the robustness and effectiveness of PointMLS.

Text-Driven Traffic Anomaly Detection with Temporal High-Frequency Modeling in Driving Videos

Traffic anomaly detection (TAD) in driving videos is critical for ensuring the safety of autonomous driving and advanced driver assistance systems. Previous single-stage TAD methods primarily rely on frame prediction, making them vulnerable to interference from dynamic backgrounds induced by the rapid movement of the dashboard camera. While two-stage TAD methods appear to be a natural solution to mitigate such interference by pre-extracting background-independent features (such as bounding boxes and optical flow) using perceptual algorithms, they are susceptible to the performance of first-stage perceptual algorithms and may result in error propagation. In this paper, we introduce TTHF, a novel single-stage method aligning video clips with text prompts, offering a new perspective on traffic anomaly detection. Unlike previous approaches, the supervised signal of our method is derived from languages rather than orthogonal one-hot vectors, providing a more comprehensive representation. Further, concerning visual representation, we propose to model the high frequency of driving videos in the temporal domain. This modeling captures the dynamic changes of driving scenes, enhances the perception of driving behavior, and significantly improves the detection of traffic anomalies. In addition, to better perceive various types of traffic anomalies, we carefully design an attentive anomaly focusing mechanism that visually and linguistically guides the model to adaptively focus on the visual context of interest, thereby facilitating the detection of traffic anomalies. It is shown that our proposed TTHF achieves promising performance, outperforming state-of-the-art competitors by +5.4% AUC on the DoTA dataset and achieving high generalization on the DADA dataset.

SP-DiffDose: A Conditional Diffusion Model for Radiation Dose Prediction Based on Multi-Scale Fusion of Anatomical Structures, Guided by SwinTransformer and Projector

Radiation therapy serves as an effective and standard method for cancer treatment. Excellent radiation therapy plans always rely on high-quality dose distribution maps obtained through repeated trial and error by experienced experts. However, due to individual differences and complex clinical situations, even seasoned expert teams may need help to achieve the best treatment plan every time quickly. Many automatic dose distribution prediction methods have been proposed recently to accelerate the radiation therapy planning process and have achieved good results. However, these results suffer from over-smoothing issues, with the obtained dose distribution maps needing more high-frequency details, limiting their clinical application. To address these limitations, we propose a dose prediction diffusion model based on SwinTransformer and a projector, SP-DiffDose. To capture the direct correlation between anatomical structure and dose distribution maps, SP-DiffDose uses a structural encoder to extract features from anatomical images, then employs a conditional diffusion process to blend noise and anatomical images at multiple scales and gradually map them to dose distribution maps. To enhance the dose prediction distribution for organs at risk, SP-DiffDose utilizes SwinTransformer in the deeper layers of the network to capture features at different scales in the image. To learn good representations from the fused features, SP-DiffDose passes the fused features through a designed projector, improving dose prediction accuracy. Finally, we evaluate SP-DiffDose on an internal dataset. The results show that SP-DiffDose outperforms existing methods on multiple evaluation metrics, demonstrating the superiority and generalizability of our method.

Skeleton-in-Context: Unified Skeleton Sequence Modeling with In-Context Learning

In-context learning provides a new perspective for multi-task modeling for vision and NLP. Under this setting, the model can perceive tasks from prompts and accomplish them without any extra task-specific head predictions or model fine-tuning. However, Skeleton sequence modeling via in-context learning remains unexplored. Directly applying existing in-context models from other areas onto skeleton sequences fails due to the inter-frame and cross-task pose similarity that makes it outstandingly hard to perceive the task correctly from a subtle context. To address this challenge, we propose Skeleton-in-Context (SiC), an effective framework for in-context skeleton sequence modeling. Our SiC is able to handle multiple skeleton-based tasks simultaneously after a single training process and accomplish each task from context according to the given prompt. It can further generalize to new, unseen tasks according to customized prompts. To facilitate context perception, we additionally propose a task-unified prompt, which adaptively learns tasks of different natures, such as partial joint-level generation, sequence-level prediction, or 2D-to-3D motion prediction. We conduct extensive experiments to evaluate the effectiveness of our SiC on multiple tasks, including motion prediction, pose estimation, joint completion, and future pose estimation. We also evaluate its generalization capability on unseen tasks such as motion-in-between. These experiments show that our model achieves state-of-the-art multi-task performance and even outperforms single-task methods on certain tasks.

FedLPA: Personalized One-shot Federated Learning with Layer-Wise Posterior Aggregation

Efficiently aggregating trained neural networks from local clients into a global model on a server is a widely researched topic in federated learning. Recently, motivated by diminishing privacy concerns, mitigating potential attacks, and reducing the overhead of communication, one-shot federated learning (i.e., limiting client-server communication into a single round) has gained popularity among researchers. However, the one-shot aggregation performances are sensitively affected by the non-identical training data distribution, which exhibits high statistical heterogeneity in some real-world scenarios. To address this issue, we propose a novel one-shot aggregation method with Layer-wise Posterior Aggregation, named FedLPA. FedLPA aggregates local models to obtain a more accurate global model without requiring extra auxiliary datasets or exposing any confidential local information, e.g., label distributions. To effectively capture the statistics maintained in the biased local datasets in the practical non-IID scenario, we efficiently infer the posteriors of each layer in each local model using layer-wise Laplace approximation and aggregate them to train the global parameters. Extensive experimental results demonstrate that FedLPA significantly improves learning performance over state-of-the-art methods across several metrics.