TICON: A Slide-Level Tile Contextualizer for Histopathology Representation Learning

The interpretation of small tiles in large whole slide images (WSI) often needs a larger image context. We introduce TICON, a transformer-based tile representation contextualizer that produces rich, contextualized embeddings for ''any'' application in computational pathology. Standard tile encoder-based pipelines, which extract embeddings of tiles stripped from their context, fail to model the rich slide-level information essential for both local and global tasks. Furthermore, different tile-encoders excel at different downstream tasks. Therefore, a unified model is needed to contextualize embeddings derived from ''any'' tile-level foundation model. TICON addresses this need with a single, shared encoder, pretrained using a masked modeling objective to simultaneously unify and contextualize representations from diverse tile-level pathology foundation models. Our experiments demonstrate that TICON-contextualized embeddings significantly improve performance across many different tasks, establishing new state-of-the-art results on tile-level benchmarks (i.e., HEST-Bench, THUNDER, CATCH) and slide-level benchmarks (i.e., Patho-Bench). Finally, we pretrain an aggregator on TICON to form a slide-level foundation model, using only 11K WSIs, outperforming SoTA slide-level foundation models pretrained with up to 350K WSIs.

Sublinear Sketches for Approximate Nearest Neighbor and Kernel Density Estimation

Approximate Nearest Neighbor (ANN) search and Approximate Kernel Density Estimation (A-KDE) are fundamental problems at the core of modern machine learning, with broad applications in data analysis, information systems, and large-scale decision making. In massive and dynamic data streams, a central challenge is to design compact sketches that preserve essential structural properties of the data while enabling efficient queries. In this work, we develop new sketching algorithms that achieve sublinear space and query time guarantees for both ANN and A-KDE for a dynamic stream of data. For ANN in the streaming model, under natural assumptions, we design a sublinear sketch that requires only $\mathcal{O}(n^{1+\rho-\eta})$ memory by storing only a sublinear ($n^{-\eta}$) fraction of the total inputs, where $\rho$ is a parameter of the LSH family, and $0<\eta<1$. Our method supports sublinear query time, batch queries, and extends to the more general Turnstile model. While earlier works have focused on Exact NN, this is the first result on ANN that achieves near-optimal trade-offs between memory size and approximation error. Next, for A-KDE in the Sliding-Window model, we propose a sketch of size $\mathcal{O}\left(RW \cdot \frac{1}{\sqrt{1+\epsilon} - 1} \log^2 N\right)$, where $R$ is the number of sketch rows, $W$ is the LSH range, $N$ is the window size, and $\epsilon$ is the approximation error. This, to the best of our knowledge, is the first theoretical sublinear sketch guarantee for A-KDE in the Sliding-Window model. We complement our theoretical results with experiments on various real-world datasets, which show that the proposed sketches are lightweight and achieve consistently low error in practice.

GECKO: Gigapixel Vision-Concept Contrastive Pretraining in Histopathology

Pretraining a Multiple Instance Learning (MIL) aggregator enables the derivation of Whole Slide Image (WSI)-level embeddings from patch-level representations without supervision. While recent multimodal MIL pretraining approaches leveraging auxiliary modalities have demonstrated performance gains over unimodal WSI pretraining, the acquisition of these additional modalities necessitates extensive clinical profiling. This requirement increases costs and limits scalability in existing WSI datasets lacking such paired modalities. To address this, we propose Gigapixel Vision-Concept Knowledge Contrastive pretraining (GECKO), which aligns WSIs with a Concept Prior derived from the available WSIs. First, we derive an inherently interpretable concept prior by computing the similarity between each WSI patch and textual descriptions of predefined pathology concepts. GECKO then employs a dual-branch MIL network: one branch aggregates patch embeddings into a WSI-level deep embedding, while the other aggregates the concept prior into a corresponding WSI-level concept embedding. Both aggregated embeddings are aligned using a contrastive objective, thereby pretraining the entire dual-branch MIL model. Moreover, when auxiliary modalities such as transcriptomics data are available, GECKO seamlessly integrates them. Across five diverse tasks, GECKO consistently outperforms prior unimodal and multimodal pretraining approaches while also delivering clinically meaningful interpretability that bridges the gap between computational models and pathology expertise. Code is made available at https://github.com/bmi-imaginelab/GECKO

SKI Models: Skeleton Induced Vision-Language Embeddings for Understanding Activities of Daily Living

The introduction of vision-language models like CLIP has enabled the development of foundational video models capable of generalizing to unseen videos and human actions. However, these models are typically trained on web videos, which often fail to capture the challenges present in Activities of Daily Living (ADL) videos. Existing works address ADL-specific challenges, such as similar appearances, subtle motion patterns, and multiple viewpoints, by combining 3D skeletons and RGB videos. However, these approaches are not integrated with language, limiting their ability to generalize to unseen action classes. In this paper, we introduce SKI models, which integrate 3D skeletons into the vision-language embedding space. SKI models leverage a skeleton-language model, SkeletonCLIP, to infuse skeleton information into Vision Language Models (VLMs) and Large Vision Language Models (LVLMs) through collaborative training. Notably, SKI models do not require skeleton data during inference, enhancing their robustness for real-world applications. The effectiveness of SKI models is validated on three popular ADL datasets for zero-shot action recognition and video caption generation tasks.

MS-Temba : Multi-Scale Temporal Mamba for Efficient Temporal Action Detection

Action detection in real-world scenarios is particularly challenging due to densely distributed actions in hour-long untrimmed videos. It requires modeling both short- and long-term temporal relationships while handling significant intra-class temporal variations. Previous state-of-the-art (SOTA) Transformer-based architectures, though effective, are impractical for real-world deployment due to their high parameter count, GPU memory usage, and limited throughput, making them unsuitable for very long videos. In this work, we innovatively adapt the Mamba architecture for action detection and propose Multi-scale Temporal Mamba (MS-Temba), comprising two key components: Temporal Mamba (Temba) Blocks and the Temporal Mamba Fuser. Temba Blocks include the Temporal Local Module (TLM) for short-range temporal modeling and the Dilated Temporal SSM (DTS) for long-range dependencies. By introducing dilations, a novel concept for Mamba, TLM and DTS capture local and global features at multiple scales. The Temba Fuser aggregates these scale-specific features using Mamba to learn comprehensive multi-scale representations of untrimmed videos. MS-Temba is validated on three public datasets, outperforming SOTA methods on long videos and matching prior methods on short videos while using only one-eighth of the parameters.

From My View to Yours: Ego-Augmented Learning in Large Vision Language Models for Understanding Exocentric Daily Living Activities

Large Vision Language Models (LVLMs) have demonstrated impressive capabilities in video understanding, yet their adoption for Activities of Daily Living (ADL) remains limited by their inability to capture fine-grained interactions and spatial relationships. This limitation is particularly evident in ADL tasks, where understanding detailed human-object interaction and human-centric motion is crucial for applications such as elderly monitoring and cognitive assessment. To address this, we aim to leverage the complementary nature of egocentric views to enhance LVLM's understanding of exocentric ADL videos. Consequently, we propose an online ego2exo distillation approach to learn ego-augmented exo representations in LVLMs. While effective, this approach requires paired ego-exo training data, which is impractical to collect for real-world ADL scenarios. Consequently, we develop EgoMimic, a skeleton-guided method that can generate mimicked ego views from exocentric videos. We find that the exo representations of our ego-augmented LVLMs successfully learn to extract ego-perspective cues, demonstrated through comprehensive evaluation on six ADL benchmarks and our proposed EgoPerceptionMCQ benchmark designed specifically to assess egocentric understanding from exocentric videos. Code, models, and data will be open-sourced at https://github.com/dominickrei/EgoExo4ADL.

GenHMR: Generative Human Mesh Recovery

Human mesh recovery (HMR) is crucial in many computer vision applications; from health to arts and entertainment. HMR from monocular images has predominantly been addressed by deterministic methods that output a single prediction for a given 2D image. However, HMR from a single image is an ill-posed problem due to depth ambiguity and occlusions. Probabilistic methods have attempted to address this by generating and fusing multiple plausible 3D reconstructions, but their performance has often lagged behind deterministic approaches. In this paper, we introduce GenHMR, a novel generative framework that reformulates monocular HMR as an image-conditioned generative task, explicitly modeling and mitigating uncertainties in the 2D-to-3D mapping process. GenHMR comprises two key components: (1) a pose tokenizer to convert 3D human poses into a sequence of discrete tokens in a latent space, and (2) an image-conditional masked transformer to learn the probabilistic distributions of the pose tokens, conditioned on the input image prompt along with randomly masked token sequence. During inference, the model samples from the learned conditional distribution to iteratively decode high-confidence pose tokens, thereby reducing 3D reconstruction uncertainties. To further refine the reconstruction, a 2D pose-guided refinement technique is proposed to directly fine-tune the decoded pose tokens in the latent space, which forces the projected 3D body mesh to align with the 2D pose clues. Experiments on benchmark datasets demonstrate that GenHMR significantly outperforms state-of-the-art methods. Project website can be found at https://m-usamasaleem.github.io/publication/GenHMR/GenHMR.html

MMHMR: Generative Masked Modeling for Hand Mesh Recovery

Reconstructing a 3D hand mesh from a single RGB image is challenging due to complex articulations, self-occlusions, and depth ambiguities. Traditional discriminative methods, which learn a deterministic mapping from a 2D image to a single 3D mesh, often struggle with the inherent ambiguities in 2D-to-3D mapping. To address this challenge, we propose MMHMR, a novel generative masked model for hand mesh recovery that synthesizes plausible 3D hand meshes by learning and sampling from the probabilistic distribution of the ambiguous 2D-to-3D mapping process. MMHMR consists of two key components: (1) a VQ-MANO, which encodes 3D hand articulations as discrete pose tokens in a latent space, and (2) a Context-Guided Masked Transformer that randomly masks out pose tokens and learns their joint distribution, conditioned on corrupted token sequences, image context, and 2D pose cues. This learned distribution facilitates confidence-guided sampling during inference, producing mesh reconstructions with low uncertainty and high precision. Extensive evaluations on benchmark and real-world datasets demonstrate that MMHMR achieves state-of-the-art accuracy, robustness, and realism in 3D hand mesh reconstruction. Project website: https://m-usamasaleem.github.io/publication/MMHMR/mmhmr.html

Self-supervised Auxiliary Learning for Texture and Model-based Hybrid Robust and Fair Featuring in Face Analysis

In this work, we explore Self-supervised Learning (SSL) as an auxiliary task to blend the texture-based local descriptors into feature modelling for efficient face analysis. Combining a primary task and a self-supervised auxiliary task is beneficial for robust representation. Therefore, we used the SSL task of mask auto-encoder (MAE) as an auxiliary task to reconstruct texture features such as local patterns along with the primary task for robust and unbiased face analysis. We experimented with our hypothesis on three major paradigms of face analysis: face attribute and face-based emotion analysis, and deepfake detection. Our experiment results exhibit that better feature representation can be gleaned from our proposed model for fair and bias-less face analysis.

Frequency Guidance Matters: Skeletal Action Recognition by Frequency-Aware Mixed Transformer

Recently, transformers have demonstrated great potential for modeling long-term dependencies from skeleton sequences and thereby gained ever-increasing attention in skeleton action recognition. However, the existing transformer-based approaches heavily rely on the naive attention mechanism for capturing the spatiotemporal features, which falls short in learning discriminative representations that exhibit similar motion patterns. To address this challenge, we introduce the Frequency-aware Mixed Transformer (FreqMixFormer), specifically designed for recognizing similar skeletal actions with subtle discriminative motions. First, we introduce a frequency-aware attention module to unweave skeleton frequency representations by embedding joint features into frequency attention maps, aiming to distinguish the discriminative movements based on their frequency coefficients. Subsequently, we develop a mixed transformer architecture to incorporate spatial features with frequency features to model the comprehensive frequency-spatial patterns. Additionally, a temporal transformer is proposed to extract the global correlations across frames. Extensive experiments show that FreqMiXFormer outperforms SOTA on 3 popular skeleton action recognition datasets, including NTU RGB+D, NTU RGB+D 120, and NW-UCLA datasets.