Artificial intelligence-enabled single-lead ECG for non-invasive hyperkalemia detection: development, multicenter validation, and proof-of-concept deployment

Hyperkalemia is a life-threatening electrolyte disorder that is common in patients with chronic kidney disease and heart failure, yet frequent monitoring remains difficult outside hospital settings. We developed and validated Pocket-K, a single-lead AI-ECG system initialized from the ECGFounder foundation model for non-invasive hyperkalemia screening and handheld deployment. In this multicentre observational study using routinely collected clinical ECG and laboratory data, 34,439 patients contributed 62,290 ECG--potassium pairs. Lead I data were used to fine-tune the model. Data from Peking University People's Hospital were divided into development and temporal validation sets, and data from The Second Hospital of Tianjin Medical University served as an independent external validation set. Hyperkalemia was defined as venous serum potassium > 5.5 mmol/L. Pocket-K achieved AUROCs of 0.936 in internal testing, 0.858 in temporal validation, and 0.808 in external validation. For KDIGO-defined moderate-to-severe hyperkalemia (serum potassium >= 6.0 mmol/L), AUROCs increased to 0.940 and 0.861 in the temporal and external sets, respectively. External negative predictive value exceeded 99.3%. Model-predicted high risk below the hyperkalemia threshold was more common in patients with chronic kidney disease and heart failure. A handheld prototype enabled near-real-time inference, supporting future prospective evaluation in native handheld and wearable settings.

ECGFlowCMR: Pretraining with ECG-Generated Cine CMR Improves Cardiac Disease Classification and Phenotype Prediction

Cardiac Magnetic Resonance (CMR) imaging provides a comprehensive assessment of cardiac structure and function but remains constrained by high acquisition costs and reliance on expert annotations, limiting the availability of large-scale labeled datasets. In contrast, electrocardiograms (ECGs) are inexpensive, widely accessible, and offer a promising modality for conditioning the generative synthesis of cine CMR. To this end, we propose ECGFlowCMR, a novel ECG-to-CMR generative framework that integrates a Phase-Aware Masked Autoencoder (PA-MAE) and an Anatomy-Motion Disentangled Flow (AMDF) to address two fundamental challenges: (1) the cross-modal temporal mismatch between multi-beat ECG recordings and single-cycle CMR sequences, and (2) the anatomical observability gap due to the limited structural information inherent in ECGs. Extensive experiments on the UK Biobank and a proprietary clinical dataset demonstrate that ECGFlowCMR can generate realistic cine CMR sequences from ECG inputs, enabling scalable pretraining and improving performance on downstream cardiac disease classification and phenotype prediction tasks.

Contrastive Learning with Spectrum Information Augmentation in Abnormal Sound Detection

The outlier exposure method is an effective approach to address the unsupervised anomaly sound detection problem. The key focus of this method is how to make the model learn the distribution space of normal data. Based on biological perception and data analysis, it is found that anomalous audio and noise often have higher frequencies. Therefore, we propose a data augmentation method for high-frequency information in contrastive learning. This enables the model to pay more attention to the low-frequency information of the audio, which represents the normal operational mode of the machine. We evaluated the proposed method on the DCASE 2020 Task 2. The results showed that our method outperformed other contrastive learning methods used on this dataset. We also evaluated the generalizability of our method on the DCASE 2022 Task 2 dataset.

Noise Supervised Contrastive Learning and Feature-Perturbed for Anomalous Sound Detection

Unsupervised anomalous sound detection aims to detect unknown anomalous sounds by training a model using only normal audio data. Despite advancements in self-supervised methods, the issue of frequent false alarms when handling samples of the same type from different machines remains unresolved. This paper introduces a novel training technique called one-stage supervised contrastive learning (OS-SCL), which significantly addresses this problem by perturbing features in the embedding space and employing a one-stage noisy supervised contrastive learning approach. On the DCASE 2020 Challenge Task 2, it achieved 94.64\% AUC, 88.42\% pAUC, and 89.24\% mAUC using only Log-Mel features. Additionally, a time-frequency feature named TFgram is proposed, which is extracted from raw audio. This feature effectively captures critical information for anomalous sound detection, ultimately achieving 95.71\% AUC, 90.23\% pAUC, and 91.23\% mAUC. The source code is available at: \underline{www.github.com/huangswt/OS-SCL}.