MEDNA-DFM: A Dual-View FiLM-MoE Model for Explainable DNA Methylation Prediction

Accurate computational identification of DNA methylation is essential for understanding epigenetic regulation. Although deep learning excels in this binary classification task, its "black-box" nature impedes biological insight. We address this by introducing a high-performance model MEDNA-DFM, alongside mechanism-inspired signal purification algorithms. Our investigation demonstrates that MEDNA-DFM effectively captures conserved methylation patterns, achieving robust distinction across diverse species. Validation on external independent datasets confirms that the model's generalization is driven by conserved intrinsic motifs (e.g., GC content) rather than phylogenetic proximity. Furthermore, applying our developed algorithms extracted motifs with significantly higher reliability than prior studies. Finally, empirical evidence from a Drosophila 6mA case study prompted us to propose a "sequence-structure synergy" hypothesis, suggesting that the GAGG core motif and an upstream A-tract element function cooperatively. We further validated this hypothesis via in silico mutagenesis, confirming that the ablation of either or both elements significantly degrades the model's recognition capabilities. This work provides a powerful tool for methylation prediction and demonstrates how explainable deep learning can drive both methodological innovation and the generation of biological hypotheses.

Multi-view Hand Reconstruction with a Point-Embedded Transformer

This work introduces a novel and generalizable multi-view Hand Mesh Reconstruction (HMR) model, named POEM, designed for practical use in real-world hand motion capture scenarios. The advances of the POEM model consist of two main aspects. First, concerning the modeling of the problem, we propose embedding a static basis point within the multi-view stereo space. A point represents a natural form of 3D information and serves as an ideal medium for fusing features across different views, given its varied projections across these views. Consequently, our method harnesses a simple yet effective idea: a complex 3D hand mesh can be represented by a set of 3D basis points that 1) are embedded in the multi-view stereo, 2) carry features from the multi-view images, and 3) encompass the hand in it. The second advance lies in the training strategy. We utilize a combination of five large-scale multi-view datasets and employ randomization in the number, order, and poses of the cameras. By processing such a vast amount of data and a diverse array of camera configurations, our model demonstrates notable generalizability in the real-world applications. As a result, POEM presents a highly practical, plug-and-play solution that enables user-friendly, cost-effective multi-view motion capture for both left and right hands. The model and source codes are available at https://github.com/JubSteven/POEM-v2.