A Penetration Metric for Deforming Tetrahedra using Object Norm

In this paper, we propose a novel penetration metric, called deformable penetration depth PDd, to define a measure of inter-penetration between two linearly deforming tetrahedra using the object norm. First of all, we show that a distance metric for a tetrahedron deforming between two configurations can be found in closed form based on object norm. Then, we show that the PDd between an intersecting pair of static and deforming tetrahedra can be found by solving a quadratic programming (QP) problem in terms of the distance metric with non-penetration constraints. We also show that the PDd between two, intersected, deforming tetrahedra can be found by solving a similar QP problem under some assumption on penetrating directions, and it can be also accelerated by an order of magnitude using pre-calculated penetration direction. We have implemented our algorithm on a standard PC platform using an off-the-shelf QP optimizer, and experimentally show that both the static/deformable and deformable/deformable tetrahedra cases can be solvable in from a few to tens of milliseconds. Finally, we demonstrate that our penetration metric is three-times smaller (or tighter) than the classical, rigid penetration depth metric in our experiments.

Diagnosis of Pediatric Obstructive Sleep Apnea via Face Classification with Persistent Homology and Convolutional Neural Networks

Obstructive sleep apnea is a serious condition causing a litany of health problems especially in the pediatric population. However, this chronic condition can be treated if diagnosis is possible. The gold standard for diagnosis is an overnight sleep study, which is often unobtainable by many potentially suffering from this condition. Hence, we attempt to develop a fast non-invasive diagnostic tool by training a classifier on 2D and 3D facial images of a patient to recognize facial features associated with obstructive sleep apnea. In this comparative study, we consider both persistent homology and geometric shape analysis from the field of computational topology as well as convolutional neural networks, a powerful method from deep learning whose success in image and specifically facial recognition has already been demonstrated by computer scientists.

Time Series Featurization via Topological Data Analysis: an Application to Cryptocurrency Trend Forecasting

We propose a novel methodology for feature extraction from time series data based on topological data analysis. The proposed procedure applies a dimensionality reduction technique via principal component analysis to the point cloud of the Takens' embedding from the observed time series and then evaluates the persistence landscape and silhouettes based on the corresponding Rips complex. We define a new notion of Rips distance function that is especially suited for persistence homologies built on Rips complexes and prove stability theorems for it. We use these results to demonstrate in turn some stability properties of the topological features extracted using our procedure with respect to additive noise and sampling. We further apply our method to the problem of trend forecasting for cryptocurrency prices, where we manage to achieve significantly lower error rates than more standard, non TDA-based methodologies in complex pattern classification tasks. We expect our method to provide a new insight on feature engineering for granular, noisy time series data.

Causal effects based on distributional distances

We develop a novel framework for estimating causal effects based on the discrepancy between unobserved counterfactual distributions. In our setting a causal effect is defined in terms of the $L_1$ distance between different counterfactual outcome distributions, rather than a mean difference in outcome values. Directly comparing counterfactual outcome distributions can provide more nuanced and valuable information about causality than a simple comparison of means. We consider single- and multi-source randomized studies, as well as observational studies, and analyze error bounds and asymptotic properties of the proposed estimators. We further propose methods to construct confidence intervals for the unknown mean distribution distance. Finally, we illustrate the new methods and verify their effectiveness in empirical studies.

Statistical Inference for Cluster Trees

A cluster tree provides a highly-interpretable summary of a density function by representing the hierarchy of its high-density clusters. It is estimated using the empirical tree, which is the cluster tree constructed from a density estimator. This paper addresses the basic question of quantifying our uncertainty by assessing the statistical significance of topological features of an empirical cluster tree. We first study a variety of metrics that can be used to compare different trees, analyze their properties and assess their suitability for inference. We then propose methods to construct and summarize confidence sets for the unknown true cluster tree. We introduce a partial ordering on cluster trees which we use to prune some of the statistically insignificant features of the empirical tree, yielding interpretable and parsimonious cluster trees. Finally, we illustrate the proposed methods on a variety of synthetic examples and furthermore demonstrate their utility in the analysis of a Graft-versus-Host Disease (GvHD) data set.