Causally-informed Deep Learning towards Explainable and Generalizable Outcomes Prediction in Critical Care

Recent advances in deep learning (DL) have prompted the development of high-performing early warning score (EWS) systems, predicting clinical deteriorations such as acute kidney injury, acute myocardial infarction, or circulatory failure. DL models have proven to be powerful tools for various tasks but come with the cost of lacking interpretability and limited generalizability, hindering their clinical applications. To develop a practical EWS system applicable to various outcomes, we propose causally-informed explainable early prediction model, which leverages causal discovery to identify the underlying causal relationships of prediction and thus owns two unique advantages: demonstrating the explicit interpretation of the prediction while exhibiting decent performance when applied to unfamiliar environments. Benefiting from these features, our approach achieves superior accuracy for 6 different critical deteriorations and achieves better generalizability across different patient groups, compared to various baseline algorithms. Besides, we provide explicit causal pathways to serve as references for assistant clinical diagnosis and potential interventions. The proposed approach enhances the practical application of deep learning in various medical scenarios.

UniCompress: Enhancing Multi-Data Medical Image Compression with Knowledge Distillation

In the field of medical image compression, Implicit Neural Representation (INR) networks have shown remarkable versatility due to their flexible compression ratios, yet they are constrained by a one-to-one fitting approach that results in lengthy encoding times. Our novel method, ``\textbf{UniCompress}'', innovatively extends the compression capabilities of INR by being the first to compress multiple medical data blocks using a single INR network. By employing wavelet transforms and quantization, we introduce a codebook containing frequency domain information as a prior input to the INR network. This enhances the representational power of INR and provides distinctive conditioning for different image blocks. Furthermore, our research introduces a new technique for the knowledge distillation of implicit representations, simplifying complex model knowledge into more manageable formats to improve compression ratios. Extensive testing on CT and electron microscopy (EM) datasets has demonstrated that UniCompress outperforms traditional INR methods and commercial compression solutions like HEVC, especially in complex and high compression scenarios. Notably, compared to existing INR techniques, UniCompress achieves a 4$\sim$5 times increase in compression speed, marking a significant advancement in the field of medical image compression. Codes will be publicly available.

Event-Enhanced Snapshot Compressive Videography at 10K FPS

Video snapshot compressive imaging (SCI) encodes the target dynamic scene compactly into a snapshot and reconstructs its high-speed frame sequence afterward, greatly reducing the required data footprint and transmission bandwidth as well as enabling high-speed imaging with a low frame rate intensity camera. In implementation, high-speed dynamics are encoded via temporally varying patterns, and only frames at corresponding temporal intervals can be reconstructed, while the dynamics occurring between consecutive frames are lost. To unlock the potential of conventional snapshot compressive videography, we propose a novel hybrid "intensity+event" imaging scheme by incorporating an event camera into a video SCI setup. Our proposed system consists of a dual-path optical setup to record the coded intensity measurement and intermediate event signals simultaneously, which is compact and photon-efficient by collecting the half photons discarded in conventional video SCI. Correspondingly, we developed a dual-branch Transformer utilizing the reciprocal relationship between two data modes to decode dense video frames. Extensive experiments on both simulated and real-captured data demonstrate our superiority to state-of-the-art video SCI and video frame interpolation (VFI) methods. Benefiting from the new hybrid design leveraging both intrinsic redundancy in videos and the unique feature of event cameras, we achieve high-quality videography at 0.1ms time intervals with a low-cost CMOS image sensor working at 24 FPS.

An Event-Oriented Diffusion-Refinement Method for Sparse Events Completion

Event cameras or dynamic vision sensors (DVS) record asynchronous response to brightness changes instead of conventional intensity frames, and feature ultra-high sensitivity at low bandwidth. The new mechanism demonstrates great advantages in challenging scenarios with fast motion and large dynamic range. However, the recorded events might be highly sparse due to either limited hardware bandwidth or extreme photon starvation in harsh environments. To unlock the full potential of event cameras, we propose an inventive event sequence completion approach conforming to the unique characteristics of event data in both the processing stage and the output form. Specifically, we treat event streams as 3D event clouds in the spatiotemporal domain, develop a diffusion-based generative model to generate dense clouds in a coarse-to-fine manner, and recover exact timestamps to maintain the temporal resolution of raw data successfully. To validate the effectiveness of our method comprehensively, we perform extensive experiments on three widely used public datasets with different spatial resolutions, and additionally collect a novel event dataset covering diverse scenarios with highly dynamic motions and under harsh illumination. Besides generating high-quality dense events, our method can benefit downstream applications such as object classification and intensity frame reconstruction.

A Compact Implicit Neural Representation for Efficient Storage of Massive 4D Functional Magnetic Resonance Imaging

Functional Magnetic Resonance Imaging (fMRI) data is a kind of widely used four-dimensional biomedical data, demanding effective compression but presenting unique challenges for compression due to its intricate temporal dynamics, low signal-to-noise ratio, and complicated underlying redundancies. This paper reports a novel compression paradigm specifically tailored for fMRI data based on Implicit Neural Representation (INR). The proposed approach focuses on removing the various redundancies among the time series, including (i) conducting spatial correlation modeling for intra-region dynamics, (ii) decomposing reusable neuronal activation patterns, and using proper initialization together with nonlinear fusion to describe the inter-region similarity. The above scheme properly incorporates the unique features of fMRI data, and experimental results on publicly available datasets demonstrate the effectiveness of the proposed method, surpassing state-of-the-art algorithms in both conventional image quality evaluation metrics and fMRI downstream tasks. This work in this paper paves the way for sharing massive fMRI data at low bandwidth and high fidelity.

Lightweight High-Speed Photography Built on Coded Exposure and Implicit Neural Representation of Videos

The compact cameras recording high-speed scenes with high resolution are highly demanded, but the required high bandwidth often leads to bulky, heavy systems, which limits their applications on low-capacity platforms. Adopting a coded exposure setup to encode a frame sequence into a blurry snapshot and retrieve the latent sharp video afterward can serve as a lightweight solution. However, restoring motion from blur is quite challenging due to the high ill-posedness of motion blur decomposition, intrinsic ambiguity in motion direction, and diverse motions in natural videos. In this work, by leveraging classical coded exposure imaging technique and emerging implicit neural representation for videos, we tactfully embed the motion direction cues into the blurry image during the imaging process and develop a novel self-recursive neural network to sequentially retrieve the latent video sequence from the blurry image utilizing the embedded motion direction cues. To validate the effectiveness and efficiency of the proposed framework, we conduct extensive experiments on benchmark datasets and real-captured blurry images. The results demonstrate that our proposed framework significantly outperforms existing methods in quality and flexibility. The code for our work is available at https://github.com/zhihongz/BDINR

CausalTime: Realistically Generated Time-series for Benchmarking of Causal Discovery

Time-series causal discovery (TSCD) is a fundamental problem of machine learning. However, existing synthetic datasets cannot properly evaluate or predict the algorithms' performance on real data. This study introduces the CausalTime pipeline to generate time-series that highly resemble the real data and with ground truth causal graphs for quantitative performance evaluation. The pipeline starts from real observations in a specific scenario and produces a matching benchmark dataset. Firstly, we harness deep neural networks along with normalizing flow to accurately capture realistic dynamics. Secondly, we extract hypothesized causal graphs by performing importance analysis on the neural network or leveraging prior knowledge. Thirdly, we derive the ground truth causal graphs by splitting the causal model into causal term, residual term, and noise term. Lastly, using the fitted network and the derived causal graph, we generate corresponding versatile time-series proper for algorithm assessment. In the experiments, we validate the fidelity of the generated data through qualitative and quantitative experiments, followed by a benchmarking of existing TSCD algorithms using these generated datasets. CausalTime offers a feasible solution to evaluating TSCD algorithms in real applications and can be generalized to a wide range of fields. For easy use of the proposed approach, we also provide a user-friendly website, hosted on www.causaltime.cc.

HAvatar: High-fidelity Head Avatar via Facial Model Conditioned Neural Radiance Field

The problem of modeling an animatable 3D human head avatar under light-weight setups is of significant importance but has not been well solved. Existing 3D representations either perform well in the realism of portrait images synthesis or the accuracy of expression control, but not both. To address the problem, we introduce a novel hybrid explicit-implicit 3D representation, Facial Model Conditioned Neural Radiance Field, which integrates the expressiveness of NeRF and the prior information from the parametric template. At the core of our representation, a synthetic-renderings-based condition method is proposed to fuse the prior information from the parametric model into the implicit field without constraining its topological flexibility. Besides, based on the hybrid representation, we properly overcome the inconsistent shape issue presented in existing methods and improve the animation stability. Moreover, by adopting an overall GAN-based architecture using an image-to-image translation network, we achieve high-resolution, realistic and view-consistent synthesis of dynamic head appearance. Experiments demonstrate that our method can achieve state-of-the-art performance for 3D head avatar animation compared with previous methods.

HOPE: High-order Polynomial Expansion of Black-box Neural Networks

Despite their remarkable performance, deep neural networks remain mostly ``black boxes'', suggesting inexplicability and hindering their wide applications in fields requiring making rational decisions. Here we introduce HOPE (High-order Polynomial Expansion), a method for expanding a network into a high-order Taylor polynomial on a reference input. Specifically, we derive the high-order derivative rule for composite functions and extend the rule to neural networks to obtain their high-order derivatives quickly and accurately. From these derivatives, we can then derive the Taylor polynomial of the neural network, which provides an explicit expression of the network's local interpretations. Numerical analysis confirms the high accuracy, low computational complexity, and good convergence of the proposed method. Moreover, we demonstrate HOPE's wide applications built on deep learning, including function discovery, fast inference, and feature selection. The code is available at https://github.com/HarryPotterXTX/HOPE.git.

SHoP: A Deep Learning Framework for Solving High-order Partial Differential Equations

Solving partial differential equations (PDEs) has been a fundamental problem in computational science and of wide applications for both scientific and engineering research. Due to its universal approximation property, neural network is widely used to approximate the solutions of PDEs. However, existing works are incapable of solving high-order PDEs due to insufficient calculation accuracy of higher-order derivatives, and the final network is a black box without explicit explanation. To address these issues, we propose a deep learning framework to solve high-order PDEs, named SHoP. Specifically, we derive the high-order derivative rule for neural network, to get the derivatives quickly and accurately; moreover, we expand the network into a Taylor series, providing an explicit solution for the PDEs. We conduct experimental validations four high-order PDEs with different dimensions, showing that we can solve high-order PDEs efficiently and accurately.