Beyond Segmentation: Confidence-Aware and Debiased Estimation of Ratio-based Biomarkers

Ratio-based biomarkers -- such as the proportion of necrotic tissue within a tumor -- are widely used in clinical practice to support diagnosis, prognosis and treatment planning. These biomarkers are typically estimated from soft segmentation outputs by computing region-wise ratios. Despite the high-stakes nature of clinical decision making, existing methods provide only point estimates, offering no measure of uncertainty. In this work, we propose a unified \textit{confidence-aware} framework for estimating ratio-based biomarkers. We conduct a systematic analysis of error propagation in the segmentation-to-biomarker pipeline and identify model miscalibration as the dominant source of uncertainty. To mitigate this, we incorporate a lightweight, post-hoc calibration module that can be applied using internal hospital data without retraining. We leverage a tunable parameter $Q$ to control the confidence level of the derived bounds, allowing adaptation towards clinical practice. Extensive experiments show that our method produces statistically sound confidence intervals, with tunable confidence levels, enabling more trustworthy application of predictive biomarkers in clinical workflows.

Mipmap-GS: Let Gaussians Deform with Scale-specific Mipmap for Anti-aliasing Rendering

3D Gaussian Splatting (3DGS) has attracted great attention in novel view synthesis because of its superior rendering efficiency and high fidelity. However, the trained Gaussians suffer from severe zooming degradation due to non-adjustable representation derived from single-scale training. Though some methods attempt to tackle this problem via post-processing techniques such as selective rendering or filtering techniques towards primitives, the scale-specific information is not involved in Gaussians. In this paper, we propose a unified optimization method to make Gaussians adaptive for arbitrary scales by self-adjusting the primitive properties (e.g., color, shape and size) and distribution (e.g., position). Inspired by the mipmap technique, we design pseudo ground-truth for the target scale and propose a scale-consistency guidance loss to inject scale information into 3D Gaussians. Our method is a plug-in module, applicable for any 3DGS models to solve the zoom-in and zoom-out aliasing. Extensive experiments demonstrate the effectiveness of our method. Notably, our method outperforms 3DGS in PSNR by an average of 9.25 dB for zoom-in and 10.40 dB for zoom-out on the NeRF Synthetic dataset.

Unveiling Incomplete Modality Brain Tumor Segmentation: Leveraging Masked Predicted Auto-Encoder and Divergence Learning

Brain tumor segmentation remains a significant challenge, particularly in the context of multi-modal magnetic resonance imaging (MRI) where missing modality images are common in clinical settings, leading to reduced segmentation accuracy. To address this issue, we propose a novel strategy, which is called masked predicted pre-training, enabling robust feature learning from incomplete modality data. Additionally, in the fine-tuning phase, we utilize a knowledge distillation technique to align features between complete and missing modality data, simultaneously enhancing model robustness. Notably, we leverage the Holder pseudo-divergence instead of the KLD for distillation loss, offering improve mathematical interpretability and properties. Extensive experiments on the BRATS2018 and BRATS2020 datasets demonstrate significant performance enhancements compared to existing state-of-the-art methods.