MOAB: Multi-Modal Outer Arithmetic Block For Fusion Of Histopathological Images And Genetic Data For Brain Tumor Grading

Brain tumors are an abnormal growth of cells in the brain. They can be classified into distinct grades based on their growth. Often grading is performed based on a histological image and is one of the most significant predictors of a patients prognosis, the higher the grade, the more aggressive the tumor. Correct diagnosis of a tumor grade remains challenging. Though histopathological grading has been shown to be prognostic, results are subject to interobserver variability, even among experienced pathologists. Recently, the World Health Organization reported that advances in molecular genetics have led to improvements in tumor classification. This paper seeks to integrate histological images and genetic data for improved computer-aided diagnosis. We propose a novel Multi-modal Outer Arithmetic Block (MOAB) based on arithmetic operations to combine latent representations of the different modalities for predicting the tumor grade (Grade \rom{2}, \rom{3} and \rom{4}). Extensive experiments evaluate the effectiveness of our approach. By applying MOAB to The Cancer Genome Atlas (TCGA) glioma dataset, we show that it can improve separation between similar classes (Grade \rom{2} and \rom{3}) and outperform prior state-of-the-art grade classification techniques.

FOAA: Flattened Outer Arithmetic Attention For Multimodal Tumor Classification

Fusion of multimodal healthcare data holds great promise to provide a holistic view of a patient's health, taking advantage of the complementarity of different modalities while leveraging their correlation. This paper proposes a simple and effective approach, inspired by attention, to fuse discriminative features from different modalities. We propose a novel attention mechanism, called Flattened Outer Arithmetic Attention (FOAA), which relies on outer arithmetic operators (addition, subtraction, product, and division) to compute attention scores from keys, queries and values derived from flattened embeddings of each modality. We demonstrate how FOAA can be implemented for self-attention and cross-attention, providing a reusable component in neural network architectures. We evaluate FOAA on two datasets for multimodal tumor classification and achieve state-of-the-art results, and we demonstrate that features enriched by FOAA are superior to those derived from other fusion approaches. The code is publicly available at \href{https://github.com/omniaalwazzan/FOAA}{https://github.com/omniaalwazzan/FOAA}