MedM2G: Unifying Medical Multi-Modal Generation via Cross-Guided Diffusion with Visual Invariant

Medical generative models, acknowledged for their high-quality sample generation ability, have accelerated the fast growth of medical applications. However, recent works concentrate on separate medical generation models for distinct medical tasks and are restricted to inadequate medical multi-modal knowledge, constraining medical comprehensive diagnosis. In this paper, we propose MedM2G, a Medical Multi-Modal Generative framework, with the key innovation to align, extract, and generate medical multi-modal within a unified model. Extending beyond single or two medical modalities, we efficiently align medical multi-modal through the central alignment approach in the unified space. Significantly, our framework extracts valuable clinical knowledge by preserving the medical visual invariant of each imaging modal, thereby enhancing specific medical information for multi-modal generation. By conditioning the adaptive cross-guided parameters into the multi-flow diffusion framework, our model promotes flexible interactions among medical multi-modal for generation. MedM2G is the first medical generative model that unifies medical generation tasks of text-to-image, image-to-text, and unified generation of medical modalities (CT, MRI, X-ray). It performs 5 medical generation tasks across 10 datasets, consistently outperforming various state-of-the-art works.

UniDCP: Unifying Multiple Medical Vision-language Tasks via Dynamic Cross-modal Learnable Prompts

Medical vision-language pre-training (Med-VLP) models have recently accelerated the fast-growing medical diagnostics application. However, most Med-VLP models learn task-specific representations independently from scratch, thereby leading to great inflexibility when they work across multiple fine-tuning tasks. In this work, we propose UniDCP, a Unified medical vision-language model with Dynamic Cross-modal learnable Prompts, which can be plastically applied to multiple medical vision-language tasks. Specifically, we explicitly construct a unified framework to harmonize diverse inputs from multiple pretraining tasks by leveraging cross-modal prompts for unification, which accordingly can accommodate heterogeneous medical fine-tuning tasks. Furthermore, we conceive a dynamic cross-modal prompt optimizing strategy that optimizes the prompts within the shareable space for implicitly processing the shareable clinic knowledge. UniDCP is the first Med-VLP model capable of performing all 8 medical uni-modal and cross-modal tasks over 14 corresponding datasets, consistently yielding superior results over diverse state-of-the-art methods.

UnICLAM:Contrastive Representation Learning with Adversarial Masking for Unified and Interpretable Medical Vision Question Answering

Medical Visual Question Answering (Medical-VQA) aims to to answer clinical questions regarding radiology images, assisting doctors with decision-making options. Nevertheless, current Medical-VQA models learn cross-modal representations through residing vision and texture encoders in dual separate spaces, which lead to indirect semantic alignment. In this paper, we propose UnICLAM, a Unified and Interpretable Medical-VQA model through Contrastive Representation Learning with Adversarial Masking. Specifically, to learn an aligned image-text representation, we first establish a unified dual-stream pre-training structure with the gradually soft-parameter sharing strategy. Technically, the proposed strategy learns a constraint for the vision and texture encoders to be close in a same space, which is gradually loosened as the higher number of layers. Moreover, for grasping the unified semantic representation, we extend the adversarial masking data augmentation to the contrastive representation learning of vision and text in a unified manner. Concretely, while the encoder training minimizes the distance between original and masking samples, the adversarial masking module keeps adversarial learning to conversely maximize the distance. Furthermore, we also intuitively take a further exploration to the unified adversarial masking augmentation model, which improves the potential ante-hoc interpretability with remarkable performance and efficiency. Experimental results on VQA-RAD and SLAKE public benchmarks demonstrate that UnICLAM outperforms existing 11 state-of-the-art Medical-VQA models. More importantly, we make an additional discussion about the performance of UnICLAM in diagnosing heart failure, verifying that UnICLAM exhibits superior few-shot adaption performance in practical disease diagnosis.