This paper proposes a novel approach to integrating partial differential equation (PDE)-based evolution models into neural networks through a new type of regularization. Specifically, we propose inverse evolution layers (IELs) based on evolution equations. These layers can achieve specific regularization objectives and endow neural networks' outputs with corresponding properties of the evolution models. Moreover, IELs are straightforward to construct and implement, and can be easily designed for various physical evolutions and neural networks. Additionally, the design process for these layers can provide neural networks with intuitive and mathematical interpretability, thus enhancing the transparency and explainability of the approach. To demonstrate the effectiveness, efficiency, and simplicity of our approach, we present an example of endowing semantic segmentation models with the smoothness property based on the heat diffusion model. To achieve this goal, we design heat-diffusion IELs and apply them to address the challenge of semantic segmentation with noisy labels. The experimental results demonstrate that the heat-diffusion IELs can effectively mitigate the overfitting problem caused by noisy labels.
Motivated by classical work on the numerical integration of ordinary differential equations we present a ResNet-styled neural network architecture that encodes non-expansive (1-Lipschitz) operators, as long as the spectral norms of the weights are appropriately constrained. This is to be contrasted with the ordinary ResNet architecture which, even if the spectral norms of the weights are constrained, has a Lipschitz constant that, in the worst case, grows exponentially with the depth of the network. Further analysis of the proposed architecture shows that the spectral norms of the weights can be further constrained to ensure that the network is an averaged operator, making it a natural candidate for a learned denoiser in Plug-and-Play algorithms. Using a novel adaptive way of enforcing the spectral norm constraints, we show that, even with these constraints, it is possible to train performant networks. The proposed architecture is applied to the problem of adversarially robust image classification, to image denoising, and finally to the inverse problem of deblurring.
Deep learning has shown the capability to substantially accelerate MRI reconstruction while acquiring fewer measurements. Recently, diffusion models have gained burgeoning interests as a novel group of deep learning-based generative methods. These methods seek to sample data points that belong to a target distribution from a Gaussian distribution, which has been successfully extended to MRI reconstruction. In this work, we proposed a Cold Diffusion-based MRI reconstruction method called CDiffMR. Different from conventional diffusion models, the degradation operation of our CDiffMR is based on \textit{k}-space undersampling instead of adding Gaussian noise, and the restoration network is trained to harness a de-aliaseing function. We also design starting point and data consistency conditioning strategies to guide and accelerate the reverse process. More intriguingly, the pre-trained CDiffMR model can be reused for reconstruction tasks with different undersampling rates. We demonstrated, through extensive numerical and visual experiments, that the proposed CDiffMR can achieve comparable or even superior reconstruction results than state-of-the-art models. Compared to the diffusion model-based counterpart, CDiffMR reaches readily competing results using only $1.6 \sim 3.4\%$ for inference time. The code is publicly available at https://github.com/ayanglab/CDiffMR.
Clinical data is often affected by clinically irrelevant factors such as discrepancies between measurement devices or differing processing methods between sites. In the field of machine learning (ML), these factors are known as domains and the distribution differences they cause in the data are known as domain shifts. ML models trained using data from one domain often perform poorly when applied to data from another domain, potentially leading to wrong predictions. As such, developing machine learning models that can generalise well across multiple domains is a challenging yet essential task in the successful application of ML in clinical practice. In this paper, we propose a novel disentangled autoencoder (Dis-AE) neural network architecture that can learn domain-invariant data representations for multi-label classification of medical measurements even when the data is influenced by multiple interacting domain shifts at once. The model utilises adversarial training to produce data representations from which the domain can no longer be determined. We evaluate the model's domain generalisation capabilities on synthetic datasets and full blood count (FBC) data from blood donors as well as primary and secondary care patients, showing that Dis-AE improves model generalisation on multiple domains simultaneously while preserving clinically relevant information.
Variational auto-encoders (VAEs) are one of the most popular approaches to deep generative modeling. Despite their success, images generated by VAEs are known to suffer from blurriness, due to a highly unrealistic modeling assumption that the conditional data distribution $ p(\textbf{x} | \textbf{z})$ can be approximated as an isotropic Gaussian. In this work we introduce a principled approach to modeling the conditional data distribution $p(\textbf{x} | \textbf{z})$ by incorporating a diffusion model. We show that it is possible to create a VAE-like deep latent variable model without making the Gaussian assumption on $ p(\textbf{x} | \textbf{z}) $ or even training a decoder network. A trained encoder and an unconditional diffusion model can be combined via Bayes' rule for score functions to obtain an expressive model for $ p(\textbf{x} | \textbf{z}) $. Our approach avoids making strong assumptions on the parametric form of $ p(\textbf{x} | \textbf{z}) $, and thus allows to significantly improve the performance of VAEs.
Image-to-image reconstruction problems with free or inexpensive metadata in the form of class labels appear often in biological and medical image domains. Existing text-guided or style-transfer image-to-image approaches do not translate to datasets where additional information is provided as discrete classes. We introduce and implement a model which combines image-to-image and class-guided denoising diffusion probabilistic models. We train our model on a real-world dataset of microscopy images used for drug discovery, with and without incorporating metadata labels. By exploring the properties of image-to-image diffusion with relevant labels, we show that class-guided image-to-image diffusion can improve the meaningful content of the reconstructed images and outperform the unguided model in useful downstream tasks.
Diffusion Probabilistic Models have recently shown remarkable performance in generative image modeling, attracting significant attention in the computer vision community. However, while a substantial amount of diffusion-based research has focused on generative tasks, few studies have applied diffusion models to general medical image classification. In this paper, we propose the first diffusion-based model (named DiffMIC) to address general medical image classification by eliminating unexpected noise and perturbations in medical images and robustly capturing semantic representation. To achieve this goal, we devise a dual conditional guidance strategy that conditions each diffusion step with multiple granularities to improve step-wise regional attention. Furthermore, we propose learning the mutual information in each granularity by enforcing Maximum-Mean Discrepancy regularization during the diffusion forward process. We evaluate the effectiveness of our DiffMIC on three medical classification tasks with different image modalities, including placental maturity grading on ultrasound images, skin lesion classification using dermatoscopic images, and diabetic retinopathy grading using fundus images. Our experimental results demonstrate that DiffMIC outperforms state-of-the-art methods by a significant margin, indicating the universality and effectiveness of the proposed model. Our code will be publicly available at https://github.com/scott-yjyang/DiffMIC.
Alzheimer's disease prognosis is critical for early Mild Cognitive Impairment patients for timely treatment to improve the patient's quality of life. Whilst existing prognosis techniques demonstrate potential results, they are highly limited in terms of using a single modality. Most importantly, they fail in considering a key element for prognosis: not all features extracted at the current moment may contribute to the prognosis prediction several years later. To address the current drawbacks of the literature, we propose a novel hypergraph framework based on an information bottleneck strategy (HGIB). Firstly, our framework seeks to discriminate irrelevant information, and therefore, solely focus on harmonising relevant information for future MCI conversion prediction e.g., two years later). Secondly, our model simultaneously accounts for multi-modal data based on imaging and non-imaging modalities. HGIB uses a hypergraph structure to represent the multi-modality data and accounts for various data modality types. Thirdly, the key of our model is based on a new optimisation scheme. It is based on modelling the principle of information bottleneck into loss functions that can be integrated into our hypergraph neural network. We demonstrate, through extensive experiments on ADNI, that our proposed HGIB framework outperforms existing state-of-the-art hypergraph neural networks for Alzheimer's disease prognosis. We showcase our model even under fewer labels. Finally, we further support the robustness and generalisation capabilities of our framework under both topological and feature perturbations.