Robust Autonomous Control of a Magnetic Millirobot in In Vitro Cardiac Flow

Untethered magnetic millirobots offer significant potential for minimally invasive cardiac therapies; however, achieving reliable autonomous control in pulsatile cardiac flow remains challenging. This work presents a vision-guided control framework enabling precise autonomous navigation of a magnetic millirobot in an in vitro heart phantom under physiologically relevant flow conditions. The system integrates UNet-based localization, A* path planning, and a sliding mode controller with a disturbance observer (SMC-DOB) designed for multi-coil electromagnetic actuation. Although drag forces are estimated using steady-state CFD simulations, the controller compensates for transient pulsatile disturbances during closed-loop operation. In static fluid, the SMC-DOB achieved sub-millimeter accuracy (root-mean-square error, RMSE = 0.49 mm), outperforming PID and MPC baselines. Under moderate pulsatile flow (7 cm/s peak, 20 cP), it reduced RMSE by 37% and peak error by 2.4$\times$ compared to PID. It further maintained RMSE below 2 mm (0.27 body lengths) under elevated pulsatile flow (10 cm/s peak, 20 cP) and under low-viscosity conditions (4.3 cP, 7 cm/s peak), where baseline controllers exhibited unstable or failed tracking. These results demonstrate robust closed-loop magnetic control under time-varying cardiac flow disturbances and support the feasibility of autonomous millirobot navigation for targeted drug delivery.

Fluoroscopy-Constrained Magnetic Robot Control via Zernike-Based Field Modeling and Nonlinear MPC

Magnetic actuation enables surgical robots to navigate complex anatomical pathways while reducing tissue trauma and improving surgical precision. However, clinical deployment is limited by the challenges of controlling such systems under fluoroscopic imaging, which provides low frame rate and noisy pose feedback. This paper presents a control framework that remains accurate and stable under such conditions by combining a nonlinear model predictive control (NMPC) framework that directly outputs coil currents, an analytically differentiable magnetic field model based on Zernike polynomials, and a Kalman filter to estimate the robot state. Experimental validation is conducted with two magnetic robots in a 3D-printed fluid workspace and a spine phantom replicating drug delivery in the epidural space. Results show the proposed control method remains highly accurate when feedback is downsampled to 3 Hz with added Gaussian noise (sigma = 2 mm), mimicking clinical fluoroscopy. In the spine phantom experiments, the proposed method successfully executed a drug delivery trajectory with a root mean square (RMS) position error of 1.18 mm while maintaining safe clearance from critical anatomical boundaries.

Autonomous Soft Robotic Guidewire Navigation via Imitation Learning

In endovascular surgery, endovascular interventionists push a thin tube called a catheter, guided by a thin wire to a treatment site inside the patient's blood vessels to treat various conditions such as blood clots, aneurysms, and malformations. Guidewires with robotic tips can enhance maneuverability, but they present challenges in modeling and control. Automation of soft robotic guidewire navigation has the potential to overcome these challenges, increasing the precision and safety of endovascular navigation. In other surgical domains, end-to-end imitation learning has shown promising results. Thus, we develop a transformer-based imitation learning framework with goal conditioning, relative action outputs, and automatic contrast dye injections to enable generalizable soft robotic guidewire navigation in an aneurysm targeting task. We train the model on 36 different modular bifurcated geometries, generating 647 total demonstrations under simulated fluoroscopy, and evaluate it on three previously unseen vascular geometries. The model can autonomously drive the tip of the robot to the aneurysm location with a success rate of 83% on the unseen geometries, outperforming several baselines. In addition, we present ablation and baseline studies to evaluate the effectiveness of each design and data collection choice. Project website: https://softrobotnavigation.github.io/

Enumeration of Polyominoes & Polycubes Composed of Magnetic Cubes

This paper examines a family of designs for magnetic cubes and counts how many configurations are possible for each design as a function of the number of modules. Magnetic modular cubes are cubes with magnets arranged on their faces. The magnets are positioned so that each face has either magnetic south or north pole outward. Moreover, we require that the net magnetic moment of the cube passes through the center of opposing faces. These magnetic arrangements enable coupling when cube faces with opposite polarity are brought in close proximity and enable moving the cubes by controlling the orientation of a global magnetic field. This paper investigates the 2D and 3D shapes that can be constructed by magnetic modular cubes, and describes all possible magnet arrangements that obey these rules. We select ten magnetic arrangements and assign a "colo"' to each of them for ease of visualization and reference. We provide a method to enumerate the number of unique polyominoes and polycubes that can be constructed from a given set of colored cubes. We use this method to enumerate all arrangements for up to 20 modules in 2D and 16 modules in 3D. We provide a motion planner for 2D assembly and through simulations compare which arrangements require fewer movements to generate and which arrangements are more common. Hardware demonstrations explore the self-assembly and disassembly of these modules in 2D and 3D.