Robust Autonomous Control of a Magnetic Millirobot in In Vitro Cardiac Flow

Untethered magnetic millirobots offer significant potential for minimally invasive cardiac therapies; however, achieving reliable autonomous control in pulsatile cardiac flow remains challenging. This work presents a vision-guided control framework enabling precise autonomous navigation of a magnetic millirobot in an in vitro heart phantom under physiologically relevant flow conditions. The system integrates UNet-based localization, A* path planning, and a sliding mode controller with a disturbance observer (SMC-DOB) designed for multi-coil electromagnetic actuation. Although drag forces are estimated using steady-state CFD simulations, the controller compensates for transient pulsatile disturbances during closed-loop operation. In static fluid, the SMC-DOB achieved sub-millimeter accuracy (root-mean-square error, RMSE = 0.49 mm), outperforming PID and MPC baselines. Under moderate pulsatile flow (7 cm/s peak, 20 cP), it reduced RMSE by 37% and peak error by 2.4$\times$ compared to PID. It further maintained RMSE below 2 mm (0.27 body lengths) under elevated pulsatile flow (10 cm/s peak, 20 cP) and under low-viscosity conditions (4.3 cP, 7 cm/s peak), where baseline controllers exhibited unstable or failed tracking. These results demonstrate robust closed-loop magnetic control under time-varying cardiac flow disturbances and support the feasibility of autonomous millirobot navigation for targeted drug delivery.

Fluoroscopy-Constrained Magnetic Robot Control via Zernike-Based Field Modeling and Nonlinear MPC

Magnetic actuation enables surgical robots to navigate complex anatomical pathways while reducing tissue trauma and improving surgical precision. However, clinical deployment is limited by the challenges of controlling such systems under fluoroscopic imaging, which provides low frame rate and noisy pose feedback. This paper presents a control framework that remains accurate and stable under such conditions by combining a nonlinear model predictive control (NMPC) framework that directly outputs coil currents, an analytically differentiable magnetic field model based on Zernike polynomials, and a Kalman filter to estimate the robot state. Experimental validation is conducted with two magnetic robots in a 3D-printed fluid workspace and a spine phantom replicating drug delivery in the epidural space. Results show the proposed control method remains highly accurate when feedback is downsampled to 3 Hz with added Gaussian noise (sigma = 2 mm), mimicking clinical fluoroscopy. In the spine phantom experiments, the proposed method successfully executed a drug delivery trajectory with a root mean square (RMS) position error of 1.18 mm while maintaining safe clearance from critical anatomical boundaries.