Multimodal classification of Radiation-Induced Contrast Enhancements and tumor recurrence using deep learning

The differentiation between tumor recurrence and radiation-induced contrast enhancements in post-treatment glioblastoma patients remains a major clinical challenge. Existing approaches rely on clinically sparsely available diffusion MRI or do not consider radiation maps, which are gaining increasing interest in the tumor board for this differentiation. We introduce RICE-NET, a multimodal 3D deep learning model that integrates longitudinal MRI data with radiotherapy dose distributions for automated lesion classification using conventional T1-weighted MRI data. Using a cohort of 92 patients, the model achieved an F1 score of 0.92 on an independent test set. During extensive ablation experiments, we quantified the contribution of each timepoint and modality and showed that reliable classification largely depends on the radiation map. Occlusion-based interpretability analyses further confirmed the model's focus on clinically relevant regions. These findings highlight the potential of multimodal deep learning to enhance diagnostic accuracy and support clinical decision-making in neuro-oncology.

Deep Learning Network-Temporal Models For Traffic Prediction

Time series analysis is critical for emerging net- work intelligent control and management functions. However, existing statistical-based and shallow machine learning models have shown limited prediction capabilities on multivariate time series. The intricate topological interdependency and complex temporal patterns in network data demand new model approaches. In this paper, based on a systematic multivariate time series model study, we present two deep learning models aiming for learning both temporal patterns and network topological correlations at the same time: a customized network-temporal graph attention network (GAT) model and a fine-tuned multi-modal large language model (LLM) with a clustering overture. Both models are studied against an LSTM model that already outperforms the statistical methods. Through extensive training and performance studies on a real-world network dataset, the LLM-based model demonstrates superior overall prediction and generalization performance, while the GAT model shows its strength in reducing prediction variance across the time series and horizons. More detailed analysis also reveals important insights into correlation variability and prediction distribution discrepancies over time series and different prediction horizons.

Automated Detection of Malignant Lesions in the Ovary Using Deep Learning Models and XAI

The unrestrained proliferation of cells that are malignant in nature is cancer. In recent times, medical professionals are constantly acquiring enhanced diagnostic and treatment abilities by implementing deep learning models to analyze medical data for better clinical decision, disease diagnosis and drug discovery. A majority of cancers are studied and treated by incorporating these technologies. However, ovarian cancer remains a dilemma as it has inaccurate non-invasive detection procedures and a time consuming, invasive procedure for accurate detection. Thus, in this research, several Convolutional Neural Networks such as LeNet-5, ResNet, VGGNet and GoogLeNet/Inception have been utilized to develop 15 variants and choose a model that accurately detects and identifies ovarian cancer. For effective model training, the dataset OvarianCancer&SubtypesDatasetHistopathology from Mendeley has been used. After constructing a model, we utilized Explainable Artificial Intelligence (XAI) models such as LIME, Integrated Gradients and SHAP to explain the black box outcome of the selected model. For evaluating the performance of the model, Accuracy, Precision, Recall, F1-Score, ROC Curve and AUC have been used. From the evaluation, it was seen that the slightly compact InceptionV3 model with ReLu had the overall best result achieving an average score of 94% across all the performance metrics in the augmented dataset. Lastly for XAI, the three aforementioned XAI have been used for an overall comparative analysis. It is the aim of this research that the contributions of the study will help in achieving a better detection method for ovarian cancer.

Indirect and Direct Multiuser Hybrid Beamforming for Far-Field and Near-Field Communications: A Deep Learning Approach

Hybrid beamforming for extremely large-scale multiple-input multiple-output (XL-MIMO) systems is challenging in the near field because the channel depends jointly on angle and distance, and the multiuser interference (MUI) is strong. Existing deep learning methods typically follow either a decoupled design that optimizes analog beamforming without explicitly accounting for MUI, or an end-to-end (E2E) joint analog-digital optimization that can be unstable under nonconvex constant-modulus (CM), pronounced analog-digital coupling, and gradient pattern of sum-rate loss. To address both issues, we develop a complex-valued E2E framework based on a variant minimum mean square error (variant-MMSE) criterion, where the digital precoder is eliminated in closed form via Karush-Kuhn-Tucker (KKT) conditions so that analog learning is trained with a stable objective. The network employs a grouped complex-convolution sensing front-end for uplink (UL) measurements, a shared complex multi-layer perceptron (MLP) for per-user feature extraction, and a merged constant-modulus head to output the analog precoder. In the indirect mode, the network designs hybrid beamformers from estimated channel state information (CSI). In the direct mode where explicit CSI is unavailable, the network learns the sensing operator and the analog mapping from short pilots, after which additional pilots estimate the equivalent channel and enable a KKT closed-form digital precoder. Simulations show that the indirect mode approaches the performance of iterative variant-MMSE optimization with a complexity reduction proportional to the antenna number. In the direct mode, the proposed method improves spectral efficiency over sparse-recovery pipelines and recent deep learning baselines under the same pilot budget.

NFPO: Stabilized Policy Optimization of Normalizing Flow for Robotic Policy Learning

Deep Reinforcement Learning (DRL) has experienced significant advancements in recent years and has been widely used in many fields. In DRL-based robotic policy learning, however, current de facto policy parameterization is still multivariate Gaussian (with diagonal covariance matrix), which lacks the ability to model multi-modal distribution. In this work, we explore the adoption of a modern network architecture, i.e. Normalizing Flow (NF) as the policy parameterization for its ability of multi-modal modeling, closed form of log probability and low computation and memory overhead. However, naively training NF in online Reinforcement Learning (RL) usually leads to training instability. We provide a detailed analysis for this phenomenon and successfully address it via simple but effective technique. With extensive experiments in multiple simulation environments, we show our method, NFPO could obtain robust and strong performance in widely used robotic learning tasks and successfully transfer into real-world robots.

On the Role of Reversible Instance Normalization

Data normalization is a crucial component of deep learning models, yet its role in time series forecasting remains insufficiently understood. In this paper, we identify three central challenges for normalization in time series forecasting: temporal input distribution shift, spatial input distribution shift, and conditional output distribution shift. In this context, we revisit the widely used Reversible Instance Normalization (RevIN), by showing through ablation studies that several of its components are redundant or even detrimental. Based on these observations, we draw new perspectives to improve RevIN's robustness and generalization.

A Variational Latent Equilibrium for Learning in Neuronal Circuits

Brains remain unrivaled in their ability to recognize and generate complex spatiotemporal patterns. While AI is able to reproduce some of these capabilities, deep learning algorithms remain largely at odds with our current understanding of brain circuitry and dynamics. This is prominently the case for backpropagation through time (BPTT), the go-to algorithm for learning complex temporal dependencies. In this work we propose a general formalism to approximate BPTT in a controlled, biologically plausible manner. Our approach builds on, unifies and extends several previous approaches to local, time-continuous, phase-free spatiotemporal credit assignment based on principles of energy conservation and extremal action. Our starting point is a prospective energy function of neuronal states, from which we calculate real-time error dynamics for time-continuous neuronal networks. In the general case, this provides a simple and straightforward derivation of the adjoint method result for neuronal networks, the time-continuous equivalent to BPTT. With a few modifications, we can turn this into a fully local (in space and time) set of equations for neuron and synapse dynamics. Our theory provides a rigorous framework for spatiotemporal deep learning in the brain, while simultaneously suggesting a blueprint for physical circuits capable of carrying out these computations. These results reframe and extend the recently proposed Generalized Latent Equilibrium (GLE) model.

Nyxus: A Next Generation Image Feature Extraction Library for the Big Data and AI Era

Modern imaging instruments can produce terabytes to petabytes of data for a single experiment. The biggest barrier to processing big image datasets has been computational, where image analysis algorithms often lack the efficiency needed to process such large datasets or make tradeoffs in robustness and accuracy. Deep learning algorithms have vastly improved the accuracy of the first step in an analysis workflow (region segmentation), but the expansion of domain specific feature extraction libraries across scientific disciplines has made it difficult to compare the performance and accuracy of extracted features. To address these needs, we developed a novel feature extraction library called Nyxus. Nyxus is designed from the ground up for scalable out-of-core feature extraction for 2D and 3D image data and rigorously tested against established standards. The comprehensive feature set of Nyxus covers multiple biomedical domains including radiomics and cellular analysis, and is designed for computational scalability across CPUs and GPUs. Nyxus has been packaged to be accessible to users of various skill sets and needs: as a Python package for code developers, a command line tool, as a Napari plugin for low to no-code users or users that want to visualize results, and as an Open Container Initiative (OCI) compliant container that can be used in cloud or super-computing workflows aimed at processing large data sets. Further, Nyxus enables a new methodological approach to feature extraction allowing for programmatic tuning of many features sets for optimal computational efficiency or coverage for use in novel machine learning and deep learning applications.

Sim-to-reality adaptation for Deep Reinforcement Learning applied to an underwater docking application

Deep Reinforcement Learning (DRL) offers a robust alternative to traditional control methods for autonomous underwater docking, particularly in adapting to unpredictable environmental conditions. However, bridging the "sim-to-real" gap and managing high training latencies remain significant bottlenecks for practical deployment. This paper presents a systematic approach for autonomous docking using the Girona Autonomous Underwater Vehicle (AUV) by leveraging a high-fidelity digital twin environment. We adapted the Stonefish simulator into a multiprocessing RL framework to significantly accelerate the learning process while incorporating realistic AUV dynamics, collision models, and sensor noise. Using the Proximal Policy Optimization (PPO) algorithm, we developed a 6-DoF control policy trained in a headless environment with randomized starting positions to ensure generalized performance. Our reward structure accounts for distance, orientation, action smoothness, and adaptive collision penalties to facilitate soft docking. Experimental results demonstrate that the agent achieved a success rate of over 90% in simulation. Furthermore, successful validation in a physical test tank confirmed the efficacy of the sim-to-reality adaptation, with the DRL controller exhibiting emergent behaviors such as pitch-based braking and yaw oscillations to assist in mechanical alignment.

Preliminary analysis of RGB-NIR Image Registration techniques for off-road forestry environments

RGB-NIR image registration plays an important role in sensor-fusion, image enhancement and off-road autonomy. In this work, we evaluate both classical and Deep Learning (DL) based image registration techniques to access their suitability for off-road forestry applications. NeMAR, trained under 6 different configurations, demonstrates partial success however, its GAN loss instability suggests challenges in preserving geometric consistency. MURF, when tested on off-road forestry data shows promising large scale feature alignment during shared information extraction but struggles with fine details in dense vegetation. Even though this is just a preliminary evaluation, our study necessitates further refinements for robust, multi-scale registration for off-road forest applications.