Towards Enhanced Analysis of Lung Cancer Lesions in EBUS-TBNA -- A Semi-Supervised Video Object Detection Method

This study aims to establish a computer-aided diagnostic system for lung lesions using bronchoscope endobronchial ultrasound (EBUS) to assist physicians in identifying lesion areas. During EBUS-transbronchial needle aspiration (EBUS-TBNA) procedures, physicians rely on grayscale ultrasound images to determine the location of lesions. However, these images often contain significant noise and can be influenced by surrounding tissues or blood vessels, making interpretation challenging. Previous research has lacked the application of object detection models to EBUS-TBNA, and there has been no well-defined solution for annotating the EBUS-TBNA dataset. In related studies on ultrasound images, although models have been successful in capturing target regions for their respective tasks, their training and predictions have been based on two-dimensional images, limiting their ability to leverage temporal features for improved predictions. This study introduces a three-dimensional image-based object detection model. It utilizes an attention mechanism to capture temporal correlations and we will implements a filtering mechanism to select relevant information from previous frames. Subsequently, a teacher-student model training approach is employed to optimize the model further, leveraging unlabeled data. To mitigate the impact of poor-quality pseudo-labels on the student model, we will add a special Gaussian Mixture Model (GMM) to ensure the quality of pseudo-labels.

Towards Out-of-Distribution Detection for breast cancer classification in Point-of-Care Ultrasound Imaging

Deep learning has shown to have great potential in medical applications. In critical domains as such, it is of high interest to have trustworthy algorithms which are able to tell when reliable assessments cannot be guaranteed. Detecting out-of-distribution (OOD) samples is a crucial step towards building a safe classifier. Following a previous study, showing that it is possible to classify breast cancer in point-of-care ultrasound images, this study investigates OOD detection using three different methods: softmax, energy score and deep ensembles. All methods are tested on three different OOD data sets. The results show that the energy score method outperforms the softmax method, performing well on two of the data sets. The ensemble method is the most robust, performing the best at detecting OOD samples for all three OOD data sets.

A privacy-preserving, distributed and cooperative FCM-based learning approach for Cancer Research

Distributed Artificial Intelligence is attracting interest day by day. In this paper, the authors introduce an innovative methodology for distributed learning of Particle Swarm Optimization-based Fuzzy Cognitive Maps in a privacy-preserving way. The authors design a training scheme for collaborative FCM learning that offers data privacy compliant with the current regulation. This method is applied to a cancer detection problem, proving that the performance of the model is improved by the Federated Learning process, and obtaining similar results to the ones that can be found in the literature.

Pulmonologists-Level lung cancer detection based on standard blood test results and smoking status using an explainable machine learning approach

Lung cancer (LC) remains the primary cause of cancer-related mortality, largely due to late-stage diagnoses. Effective strategies for early detection are therefore of paramount importance. In recent years, machine learning (ML) has demonstrated considerable potential in healthcare by facilitating the detection of various diseases. In this retrospective development and validation study, we developed an ML model based on dynamic ensemble selection (DES) for LC detection. The model leverages standard blood sample analysis and smoking history data from a large population at risk in Denmark. The study includes all patients examined on suspicion of LC in the Region of Southern Denmark from 2009 to 2018. We validated and compared the predictions by the DES model with diagnoses provided by five pulmonologists. Among the 38,944 patients, 9,940 had complete data of which 2,505 (25\%) had LC. The DES model achieved an area under the roc curve of 0.77$\pm$0.01, sensitivity of 76.2\%$\pm$2.4\%, specificity of 63.8\%$\pm$2.3\%, positive predictive value of 41.6\%$\pm$1.2\%, and F\textsubscript{1}-score of 53.8\%$\pm$1.1\%. The DES model outperformed all five pulmonologists, achieving a sensitivity 9\% higher than their average. The model identified smoking status, age, total calcium levels, neutrophil count, and lactate dehydrogenase as the most important factors for the detection of LC. The results highlight the successful application of the ML approach in detecting LC, surpassing pulmonologists' performance. Incorporating clinical and laboratory data in future risk assessment models can improve decision-making and facilitate timely referrals.

Lung Cancer Detection from CT Scan Images based on Genetic-Independent Recurrent Deep Learning

Lung cancer is one of the prevalence diseases in the world which cause many deaths. Detecting early stages of lung cancer is so necessary. So, modeling and simulating some intelligent medical systems is an essential which can help specialist to accurately determine and diagnose the disease. So this paper contributes a new lung cancer detection model in CT images which use machine learning methods. There are three steps in this model: noise reduction (pre-processing), segmentation (middle-processing) and optimize segmentation for detect exact are of nodules. This article use some filters for noise reduction and then use Independent Recurrent Neural Networks (IndRNN) as deep learning methods for segmentation which optimize and tune by Genetic Algorithm. The results represented that the proposed method can detect exact area of nodules in CT images.

Harnessing Transformers: A Leap Forward in Lung Cancer Image Detection

This paper discusses the role of Transfer Learning (TL) and transformers in cancer detection based on image analysis. With the enormous evolution of cancer patients, the identification of cancer cells in a patient's body has emerged as a trend in the field of Artificial Intelligence (AI). This process involves analyzing medical images, such as Computed Tomography (CT) scans and Magnetic Resonance Imaging (MRIs), to identify abnormal growths that may help in cancer detection. Many techniques and methods have been realized to improve the quality and performance of cancer classification and detection, such as TL, which allows the transfer of knowledge from one task to another with the same task or domain. TL englobes many methods, particularly those used in image analysis, such as transformers and Convolutional Neural Network (CNN) models trained on the ImageNet dataset. This paper analyzes and criticizes each method of TL based on image analysis and compares the results of each method, showing that transformers have achieved the best results with an accuracy of 97.41% for colon cancer detection and 94.71% for Histopathological Lung cancer. Future directions for cancer detection based on image analysis are also discussed.

Real-Time Model-Based Quantitative Ultrasound and Radar

Ultrasound and radar signals are highly beneficial for medical imaging as they are non-invasive and non-ionizing. Traditional imaging techniques have limitations in terms of contrast and physical interpretation. Quantitative medical imaging can display various physical properties such as speed of sound, density, conductivity, and relative permittivity. This makes it useful for a wider range of applications, including improving cancer detection, diagnosing fatty liver, and fast stroke imaging. However, current quantitative imaging techniques that estimate physical properties from received signals, such as Full Waveform Inversion, are time-consuming and tend to converge to local minima, making them unsuitable for medical imaging. To address these challenges, we propose a neural network based on the physical model of wave propagation, which defines the relationship between the received signals and physical properties. Our network can reconstruct multiple physical properties in less than one second for complex and realistic scenarios, using data from only eight elements. We demonstrate the effectiveness of our approach for both radar and ultrasound signals.

Rapid hyperspectral photothermal mid-infrared spectroscopic imaging from sparse data for gynecologic cancer tissue subtyping

Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several drawbacks: it is qualitative, time-intensive, and heavily dependent on the quality of staining. Mid-infrared (MIR) hyperspectral photothermal imaging is a label-free, biochemically quantitative technology that, when combined with machine learning algorithms, can eliminate the need for staining and provide quantitative results comparable to traditional histology. However, this technology is slow. This work presents a novel approach to MIR photothermal imaging that enhances its speed by an order of magnitude. Our method significantly accelerates data collection by capturing a combination of high-resolution and interleaved, lower-resolution infrared band images and applying computational techniques for data interpolation. We effectively minimize data collection requirements by leveraging sparse data acquisition and employing curvelet-based reconstruction algorithms. This method enables the reconstruction of high-quality, high-resolution images from undersampled datasets and achieving a 10X improvement in data acquisition time. We assessed the performance of our sparse imaging methodology using a variety of quantitative metrics, including mean squared error (MSE), structural similarity index (SSIM), and tissue subtype classification accuracies, employing both random forest and convolutional neural network (CNN) models, accompanied by ROC curves. Our statistically robust analysis, based on data from 100 ovarian cancer patient samples and over 65 million data points, demonstrates the method's capability to produce superior image quality and accurately distinguish between different gynecological tissue types with segmentation accuracy exceeding 95%.

Towards Chip-in-the-loop Spiking Neural Network Training via Metropolis-Hastings Sampling

This paper studies the use of Metropolis-Hastings sampling for training Spiking Neural Network (SNN) hardware subject to strong unknown non-idealities, and compares the proposed approach to the common use of the backpropagation of error (backprop) algorithm and surrogate gradients, widely used to train SNNs in literature. Simulations are conducted within a chip-in-the-loop training context, where an SNN subject to unknown distortion must be trained to detect cancer from measurements, within a biomedical application context. Our results show that the proposed approach strongly outperforms the use of backprop by up to $27\%$ higher accuracy when subject to strong hardware non-idealities. Furthermore, our results also show that the proposed approach outperforms backprop in terms of SNN generalization, needing $>10 \times$ less training data for achieving effective accuracy. These findings make the proposed training approach well-suited for SNN implementations in analog subthreshold circuits and other emerging technologies where unknown hardware non-idealities can jeopardize backprop.

Pathological Primitive Segmentation Based on Visual Foundation Model with Zero-Shot Mask Generation

Medical image processing usually requires a model trained with carefully crafted datasets due to unique image characteristics and domain-specific challenges, especially in pathology. Primitive detection and segmentation in digitized tissue samples are essential for objective and automated diagnosis and prognosis of cancer. SAM (Segment Anything Model) has recently been developed to segment general objects from natural images with high accuracy, but it requires human prompts to generate masks. In this work, we present a novel approach that adapts pre-trained natural image encoders of SAM for detection-based region proposals. Regions proposed by a pre-trained encoder are sent to cascaded feature propagation layers for projection. Then, local semantic and global context is aggregated from multi-scale for bounding box localization and classification. Finally, the SAM decoder uses the identified bounding boxes as essential prompts to generate a comprehensive primitive segmentation map. The entire base framework, SAM, requires no additional training or fine-tuning but could produce an end-to-end result for two fundamental segmentation tasks in pathology. Our method compares with state-of-the-art models in F1 score for nuclei detection and binary/multiclass panoptic(bPQ/mPQ) and mask quality(dice) for segmentation quality on the PanNuke dataset while offering end-to-end efficiency. Our model also achieves remarkable Average Precision (+4.5%) on the secondary dataset (HuBMAP Kidney) compared to Faster RCNN. The code is publicly available at https://github.com/learner-codec/autoprom_sam.