Agentifying Patient Dynamics within LLMs through Interacting with Clinical World Model

Sepsis management in the ICU requires sequential treatment decisions under rapidly evolving patient physiology. Although large language models (LLMs) encode broad clinical knowledge and can reason over guidelines, they are not inherently grounded in action-conditioned patient dynamics. We introduce SepsisAgent, a world model-augmented LLM agent for sepsis treatment recommendation. SepsisAgent uses a learned Clinical World Model to simulate patient responses under candidate fluid--vasopressor interventions, and follows a propose--simulate--refine workflow before committing to a prescription. We first show that world-model access alone yields inconsistent LLM decision performance, motivating agent-specific training. We then train SepsisAgent through a three-stage curriculum: patient-dynamics supervised fine-tuning, propose--simulate--refine behavior cloning, and world-model-based agentic reinforcement learning. On MIMIC-IV sepsis trajectories, SepsisAgent outperforms all traditional RL and LLM-based baselines in off-policy value while achieving the best safety profile under guideline adherence and unsafe-action metrics. Further analysis shows that repeated interaction with the Clinical World Model enables the agent to learn regularities in patient evolution, which remain useful even when simulator access is removed.

VerbalValue: A Socially Intelligent Virtual Host for Sales-Driven Live Commerce

A skilled live-commerce host is not merely a narrator, but a sales agent who converts viewer curiosity into purchase intent through expert product knowledge, emotionally intelligent response tactics, and entertainment that serves as a vehicle for product exposure. Yet no existing AI system replicates this: conversational recommenders treat recommendation as a terminal act, while general-purpose LLMs hallucinate product claims and default to generic promotional templates that fail to engage or persuade. We present VerbalValue, a sales-conversion-oriented virtual host that turns exceptional verbal ability into real commercial value, built on three contributions. First, we construct a domain knowledge base of product specifications and a curated sales terminology lexicon that anchor product-related responses in verified expertise. Second, we collect and annotate 1,475 live-commerce interactions spanning diverse viewer intents. Third, we fine-tune a large language model on this data to deliver empathetic, commercially oriented responses, adapting to viewer intent through empathetic amplification, evidence-backed rebuttal, and humor-mediated deflection. Experiments against GPT-5.4, Claude Sonnet 4.6, Gemini 3.1 Pro, and other baselines demonstrate gains of 23% on informativeness and 18% on factual correctness, with consistent advantages in tactfulness and viewer engagement.

Asymmetric Generative Recommendation via Multi-Expert Projection and Multi-Faceted Hierarchical Quantization

Generative Recommendation (GenRec) models reformulate recommendation as a sequence generation task, representing items as discrete Semantic IDs used symmetrically as both inputs and prediction targets. We identify a critical dual-stage information bottleneck in this design: (1) the Input Bottleneck, where lossy quantization degrades fine-grained semantics, while popularity bias skews the learned representations toward frequent items, and (2) the Output Bottleneck, where imprecise discrete targets limit supervision quality. To address these issues, we propose AsymRec, an asymmetric continuous-discrete framework that decouples input and output representations. Specifically, Multi-expert Semantic Projection (MSP) maps continuous embeddings into the Transformer's hidden space via expert-specialized projections, preserving semantic richness and improving generalization to infrequent items. Multi-faceted Hierarchical Quantization (MHQ) constructs high-capacity, structured discrete targets through multi-view and multi-level quantization with semantic regularization, preventing dimensional collapse while retaining fine-grained distinctions. Extensive experiments demonstrate that AsymRec consistently outperforms state-of-the-art generative recommenders by an average of 15.8 %. The code will be released.

Focused PU learning from imbalanced data

We propose a new method of learning from positive and unlabeled (PU) examples in highly imbalanced datasets. Many real-world problems, such as disease gene identification, targeted marketing, fraud detection, and recommender systems, are hard to address with machine learning methods, due to limited labeled data. Often, training data comprises positive and unlabeled instances, the latter typically being dominated by negative, but including also several positive instances. While PU learning is well-studied, few methods address imbalanced settings or hard-to-detect positive examples that resemble negative ones. Our approach uses a focused empirical risk estimator, incorporating both positive and unlabeled examples to train binary classifiers. Empirical evaluations demonstrate state-of-the-art performance on imbalanced datasets under two labeling mechanisms - selecting positives completely at random (SCAR) and selecting at random (SAR). Beyond these controlled experiments, we demonstrate the value of the proposed method in the real-world application of financial misstatement detection.

Agentic Recommender System with Hierarchical Belief-State Memory

Memory-augmented LLM agents have advanced personalized recommendation, yet existing approaches universally adopt flat memory representations that conflate ephemeral signals with stable preferences, and none provides a complete lifecycle governing how memory should evolve. We propose MARS (Memory-Augmented Agentic Recommender System), a framework that treats recommendation as a partially observable problem and maintains a structured belief state that progressively abstracts noisy behavioral observations into a compact estimate of user preferences. MARS organizes this belief state into three tiers: event memory buffers raw signals, preference memory maintains fine-grained mutable chunks with explicit strength and evidence tracking, and profile memory distills all preferences into a coherent natural language narrative. A complete lifecycle of six operations -- extraction, reinforcement, weakening, consolidation, forgetting, and resynthesis -- is adaptively scheduled by an LLM-based planner rather than fixed-interval heuristics. Experiments on four InstructRec benchmark domains show that \ours achieves state-of-the-art performance with average improvements of 26.4% in HR@1 and 10.3% in NDCG@10 over the strongest baselines with further gains from agentic scheduling in evolving settings.

Towards Self-Evolving Agentic Literature Retrieval

As large language models reshape scientific research, literature retrieval faces a twofold challenge: ensuring source authenticity while maintaining a deep comprehension of academic search intents. While reliable, traditional keyword-centric search fails to capture complex research intents. Frontier LLMs can handle complex research intents, but their high cost and tendency to hallucinate remain key limitations. Here we introduce PaSaMaster, a self-evolving agentic literature retrieval system that produces relevance-scored paper rankings with evidence-grounded recommendations through iterative intent analysis, retrieval, and ranking. It is built on three key designs. First, it transforms literature retrieval from a one shot query--document matching problem into a search process that evolves over time, using ranked evidence to reveal gaps, refine intents, and guide follow-up searches. Second, it prevents hallucinated sources by treating retrieval as intent--paper relevance ranking rather than generation. Finally, PaSaMaster improves cost efficiency by separating planning from retrieval: a frontier LLM is used only for intent understanding, while large scale retrieval and relevance scoring are delegated to customized corpora and lightweight models. Evaluated on the PaSaMaster Benchmark across 38 scientific disciplines, our system exposes the severe inaccuracy and incompleteness of traditional keyword retrieval (improving F1-score by 15.6X) and the unreliability of generative LLMs (which exhibit hallucination rates up to 37.79%). Remarkably, PaSaMaster outperforms GPT-5.2 by 30.0% at a mere 1% of the computational cost while ensuring zero source hallucination: https://github.com/sjtu-sai-agents/PaSaMaster

Task-Aware Automated User Profile Generation for Recommendation Simulation Using Large Language Models

Large Language Model (LLM)-based agent simulation has emerged as a promising approach to meet the increasing demand for real-time and rigorous evaluation in modern recommender systems. A typical LLM-driven simulation framework comprises three essential components: the profile module, memory module, and action module. However, existing studies have primarily concentrated on enhancing the memory and action modules, with limited attention to profile generation, which plays a pivotal role in ensuring realistic agent behaviours and aligning simulated interactions with real user dynamics. Moreover, the scarcity of datasets specifically designed for recommendation simulations has led to heavy reliance on manually crafted profiles, significantly limiting the scalability and generalisability of simulation frameworks across different datasets. To address these challenges, this work proposes an Automated Profile Generation Framework for Recommendation Simulation, APG4RecSim, that constructs realistic, coherent, and robust user profiles with minimal supervision. Extensive experiments on three benchmark datasets demonstrate that APG4RecSim achieves the best overall performance on discrimination, ranking, and rating tasks, improving ranking quality by up to 7% in nDCG@10 and reducing rating distribution divergence by 8% in JSD compared to existing profile-generation baselines. Beyond overall performance gains, our results show that profiles generated by APG4RecSim are resilient to popularity- and position-induced biases and maintain stable performance across datasets and different LLMs.

TurboGR: An Accelerated Training System for Large-Scale Generative Recommendation

Generative recommendation (GR) has emerged as a promising paradigm that replaces fragmented, scenario-specific architectures with unified Transformer-based models, exhibiting scaling-law behavior where recommendation quality improves systematically with increased model capacity and training data. However, deploying GR at scale on Ascend NPUs faces fundamental system-level challenges. These challenges are further exacerbated on Ascend NPUs due to the absence of high-performance implementations for jagged operators and the architectural mismatch between irregular sparse primitives and NPU's dense-computation-optimized design. In this paper, we present \model, an Ascend-affinity training system for generative recommendation that systematically addresses these bottlenecks through three core innovations: (i) Ascend-affinity jagged acceleration, including fusion operators that eliminate padding redundancy and dynamic load balancing that reduces inter-device imbalance from 47\% to 2.4\%; (ii) distributed communication optimization, comprising hierarchical sparse parallelism, semi-asynchronous training with proven convergence guarantees, and fine-grained pipeline orchestration that sustains 94\% NPU utilization; and (iii) negative sampling optimization via asynchronous offloading, jaggedness-aware FP16 quantization, and intra-batch logit sharing that expand the effective negative space without additional embedding lookups. Evaluated on the KuaiRand-27K dataset, \model supports training at up to 0.2B parameters and achieves 54.71\% MFU with near-linear scalability (0.97).

Checkup2Action: A Multimodal Clinical Check-up Report Dataset for Patient-Oriented Action Card Generation

Clinical check-up reports are multimodal documents that combine page layouts, tables, numerical biomarkers, abnormality flags, imaging findings, and domain-specific terminology. Such heterogeneous evidence is difficult for laypersons to interpret and translate into concrete follow-up actions. Although large language models show promise in medical summarisation and triage support, their ability to generate safe, prioritised, and patient-oriented actions from multimodal check-up reports remains under-benchmarked. We present \textbf{Checkup2Action}, a multimodal clinical check-up report dataset and benchmark for structured \textit{Action Card} generation. Each card describes one clinically relevant issue and specifies its priority, recommended department, follow-up time window, patient-facing explanation, and questions for clinicians, while avoiding diagnostic or treatment-prescriptive claims. The dataset contains 2,000 de-identified real-world check-up reports covering demographic information, physical examinations, laboratory tests, cardiovascular assessments, and imaging-related evidence. We formulate checkup-to-action generation as a constrained structured generation task and introduce an evaluation protocol covering issue coverage and precision, priority consistency, department and time recommendation accuracy, action complexity, usefulness, readability, and safety compliance. Experiments with general-purpose and medical large language models reveal clear trade-offs between issue coverage, action correctness, conciseness, and safety alignment. Checkup2Action provides a new multimodal benchmark for evaluating patient-oriented reasoning over clinical check-up reports.

F-GRPO: Factorized Group-Relative Policy Optimization for Unified Candidate Generation and Ranking

Traditional retrieval pipelines optimize utility through stages of candidate retrieval and reranking, where ranking operates over a predefined candidate set. Large Language Models (LLMs) broaden this into a generative process: given a candidate pool, an LLM can generate a subset and order it within a single autoregressive pass. However, this flexibility introduces a new optimization challenge: the model must search a combinatorial output space while receiving utility feedback only after the full ranked list is generated. Because this feedback is defined over the completed sequence, it cannot distinguish whether a poor result arises from failing to generate a relevant subset or from failing to rank that subset correctly. This credit assignment gap makes end-to-end optimization unstable and sample-inefficient. Existing systems often address this by separating candidate generation from ranking. However, such decoupling remains misaligned with downstream utility because ranking is limited by the candidate set it receives. To bridge this gap, we propose a unified framework that performs both within a single autoregressive rollout and optimizes them end-to-end via factorized group-relative policy optimization (F-GRPO). Our framework factorizes the policy into candidate generation and ranking while sharing a single LLM backbone, and jointly trains them with an order-invariant coverage reward and a position-aware utility reward. To address the resulting phase-specific credit assignment problem, we use separate group-relative advantages for generation and ranking within a two-phase sequence-level objective. Across sequential recommendation and multi-hop question answering benchmarks, F-GRPO improves top-ranked performance over GRPO and decoupled baselines, outperforms supervised alternatives, and remains competitive with strong zero-shot rerankers, with no architectural changes at inference time.