Domain-specific or Uncertainty-aware models: Does it really make a difference for biomedical text classification?

The success of pretrained language models (PLMs) across a spate of use-cases has led to significant investment from the NLP community towards building domain-specific foundational models. On the other hand, in mission critical settings such as biomedical applications, other aspects also factor in-chief of which is a model's ability to produce reasonable estimates of its own uncertainty. In the present study, we discuss these two desiderata through the lens of how they shape the entropy of a model's output probability distribution. We find that domain specificity and uncertainty awareness can often be successfully combined, but the exact task at hand weighs in much more strongly.

Adaptive Cascading Network for Continual Test-Time Adaptation

We study the problem of continual test-time adaption where the goal is to adapt a source pre-trained model to a sequence of unlabelled target domains at test time. Existing methods on test-time training suffer from several limitations: (1) Mismatch between the feature extractor and classifier; (2) Interference between the main and self-supervised tasks; (3) Lack of the ability to quickly adapt to the current distribution. In light of these challenges, we propose a cascading paradigm that simultaneously updates the feature extractor and classifier at test time, mitigating the mismatch between them and enabling long-term model adaptation. The pre-training of our model is structured within a meta-learning framework, thereby minimizing the interference between the main and self-supervised tasks and encouraging fast adaptation in the presence of limited unlabelled data. Additionally, we introduce innovative evaluation metrics, average accuracy and forward transfer, to effectively measure the model's adaptation capabilities in dynamic, real-world scenarios. Extensive experiments and ablation studies demonstrate the superiority of our approach in a range of tasks including image classification, text classification, and speech recognition.

Controllable and Efficient Multi-Class Pathology Nuclei Data Augmentation using Text-Conditioned Diffusion Models

In the field of computational pathology, deep learning algorithms have made significant progress in tasks such as nuclei segmentation and classification. However, the potential of these advanced methods is limited by the lack of available labeled data. Although image synthesis via recent generative models has been actively explored to address this challenge, existing works have barely addressed label augmentation and are mostly limited to single-class and unconditional label generation. In this paper, we introduce a novel two-stage framework for multi-class nuclei data augmentation using text-conditional diffusion models. In the first stage, we innovate nuclei label synthesis by generating multi-class semantic labels and corresponding instance maps through a joint diffusion model conditioned by text prompts that specify the label structure information. In the second stage, we utilize a semantic and text-conditional latent diffusion model to efficiently generate high-quality pathology images that align with the generated nuclei label images. We demonstrate the effectiveness of our method on large and diverse pathology nuclei datasets, with evaluations including qualitative and quantitative analyses, as well as assessments of downstream tasks.

LLMs left, right, and center: Assessing GPT's capabilities to label political bias from web domains

This research investigates whether OpenAI's GPT-4, a state-of-the-art large language model, can accurately classify the political bias of news sources based solely on their URLs. Given the subjective nature of political labels, third-party bias ratings like those from Ad Fontes Media, AllSides, and Media Bias/Fact Check (MBFC) are often used in research to analyze news source diversity. This study aims to determine if GPT-4 can replicate these human ratings on a seven-degree scale ("far-left" to "far-right"). The analysis compares GPT-4's classifications against MBFC's, and controls for website popularity using Open PageRank scores. Findings reveal a high correlation ($\text{Spearman's } \rho = .89$, $n = 5,877$, $p < 0.001$) between GPT-4's and MBFC's ratings, indicating the model's potential reliability. However, GPT-4 abstained from classifying approximately $\frac{2}{3}$ of the dataset, particularly less popular and less biased sources. The study also identifies a slight leftward skew in GPT-4's classifications compared to MBFC's. The analysis suggests that while GPT-4 can be a scalable, cost-effective tool for political bias classification of news websites, but its use should complement human judgment to mitigate biases. Further research is recommended to explore the model's performance across different settings, languages, and additional datasets.

DEPICT: Diffusion-Enabled Permutation Importance for Image Classification Tasks

We propose a permutation-based explanation method for image classifiers. Current image-model explanations like activation maps are limited to instance-based explanations in the pixel space, making it difficult to understand global model behavior. In contrast, permutation based explanations for tabular data classifiers measure feature importance by comparing model performance on data before and after permuting a feature. We propose an explanation method for image-based models that permutes interpretable concepts across dataset images. Given a dataset of images labeled with specific concepts like captions, we permute a concept across examples in the text space and then generate images via a text-conditioned diffusion model. Feature importance is then reflected by the change in model performance relative to unpermuted data. When applied to a set of concepts, the method generates a ranking of feature importance. We show this approach recovers underlying model feature importance on synthetic and real-world image classification tasks.

CoAPT: Context Attribute words for Prompt Tuning

We propose a novel prompt tuning method called CoAPT(Context Attribute words in Prompt Tuning) for few/zero-shot image classification. The core motivation is that attributes are descriptive words with rich information about a given concept. Thus, we aim to enrich text queries of existing prompt tuning methods, improving alignment between text and image embeddings in CLIP embedding space. To do so, CoAPT integrates attribute words as additional prompts within learnable prompt tuning and can be easily incorporated into various existing prompt tuning methods. To facilitate the incorporation of attributes into text embeddings and the alignment with image embeddings, soft prompts are trained together with an additional meta-network that generates input-image-wise feature biases from the concatenated feature encodings of the image-text combined queries. Our experiments demonstrate that CoAPT leads to considerable improvements for existing baseline methods on several few/zero-shot image classification tasks, including base-to-novel generalization, cross-dataset transfer, and domain generalization. Our findings highlight the importance of combining hard and soft prompts and pave the way for future research on the interplay between text and image latent spaces in pre-trained models.

Co-synthesis of Histopathology Nuclei Image-Label Pairs using a Context-Conditioned Joint Diffusion Model

In multi-class histopathology nuclei analysis tasks, the lack of training data becomes a main bottleneck for the performance of learning-based methods. To tackle this challenge, previous methods have utilized generative models to increase data by generating synthetic samples. However, existing methods often overlook the importance of considering the context of biological tissues (e.g., shape, spatial layout, and tissue type) in the synthetic data. Moreover, while generative models have shown superior performance in synthesizing realistic histopathology images, none of the existing methods are capable of producing image-label pairs at the same time. In this paper, we introduce a novel framework for co-synthesizing histopathology nuclei images and paired semantic labels using a context-conditioned joint diffusion model. We propose conditioning of a diffusion model using nucleus centroid layouts with structure-related text prompts to incorporate spatial and structural context information into the generation targets. Moreover, we enhance the granularity of our synthesized semantic labels by generating instance-wise nuclei labels using distance maps synthesized concurrently in conjunction with the images and semantic labels. We demonstrate the effectiveness of our framework in generating high-quality samples on multi-institutional, multi-organ, and multi-modality datasets. Our synthetic data consistently outperforms existing augmentation methods in the downstream tasks of nuclei segmentation and classification.

Turning Generative Models Degenerate: The Power of Data Poisoning Attacks

The increasing use of large language models (LLMs) trained by third parties raises significant security concerns. In particular, malicious actors can introduce backdoors through poisoning attacks to generate undesirable outputs. While such attacks have been extensively studied in image domains and classification tasks, they remain underexplored for natural language generation (NLG) tasks. To address this gap, we conduct an investigation of various poisoning techniques targeting the LLM's fine-tuning phase via prefix-tuning, a Parameter Efficient Fine-Tuning (PEFT) method. We assess their effectiveness across two generative tasks: text summarization and text completion; and we also introduce new metrics to quantify the success and stealthiness of such NLG poisoning attacks. Through our experiments, we find that the prefix-tuning hyperparameters and trigger designs are the most crucial factors to influence attack success and stealthiness. Moreover, we demonstrate that existing popular defenses are ineffective against our poisoning attacks. Our study presents the first systematic approach to understanding poisoning attacks targeting NLG tasks during fine-tuning via PEFT across a wide range of triggers and attack settings. We hope our findings will aid the AI security community in developing effective defenses against such threats.

Image Inpainting Models are Effective Tools for Instruction-guided Image Editing

This is the technique report for the winning solution of the CVPR2024 GenAI Media Generation Challenge Workshop's Instruction-guided Image Editing track. Instruction-guided image editing has been largely studied in recent years. The most advanced methods, such as SmartEdit and MGIE, usually combine large language models with diffusion models through joint training, where the former provides text understanding ability, and the latter provides image generation ability. However, in our experiments, we find that simply connecting large language models and image generation models through intermediary guidance such as masks instead of joint fine-tuning leads to a better editing performance and success rate. We use a 4-step process IIIE (Inpainting-based Instruction-guided Image Editing): editing category classification, main editing object identification, editing mask acquisition, and image inpainting. Results show that through proper combinations of language models and image inpainting models, our pipeline can reach a high success rate with satisfying visual quality.

Unconstrained Open Vocabulary Image Classification: Zero-Shot Transfer from Text to Image via CLIP Inversion

We introduce NOVIC, an innovative uNconstrained Open Vocabulary Image Classifier that uses an autoregressive transformer to generatively output classification labels as language. Leveraging the extensive knowledge of CLIP models, NOVIC harnesses the embedding space to enable zero-shot transfer from pure text to images. Traditional CLIP models, despite their ability for open vocabulary classification, require an exhaustive prompt of potential class labels, restricting their application to images of known content or context. To address this, we propose an "object decoder" model that is trained on a large-scale 92M-target dataset of templated object noun sets and LLM-generated captions to always output the object noun in question. This effectively inverts the CLIP text encoder and allows textual object labels to be generated directly from image-derived embedding vectors, without requiring any a priori knowledge of the potential content of an image. The trained decoders are tested on a mix of manually and web-curated datasets, as well as standard image classification benchmarks, and achieve fine-grained prompt-free prediction scores of up to 87.5%, a strong result considering the model must work for any conceivable image and without any contextual clues.