Rethinking Data Augmentation for Single-source Domain Generalization in Medical Image Segmentation

Single-source domain generalization (SDG) in medical image segmentation is a challenging yet essential task as domain shifts are quite common among clinical image datasets. Previous attempts most conduct global-only/random augmentation. Their augmented samples are usually insufficient in diversity and informativeness, thus failing to cover the possible target domain distribution. In this paper, we rethink the data augmentation strategy for SDG in medical image segmentation. Motivated by the class-level representation invariance and style mutability of medical images, we hypothesize that unseen target data can be sampled from a linear combination of $C$ (the class number) random variables, where each variable follows a location-scale distribution at the class level. Accordingly, data augmented can be readily made by sampling the random variables through a general form. On the empirical front, we implement such strategy with constrained B$\acute{\rm e}$zier transformation on both global and local (i.e. class-level) regions, which can largely increase the augmentation diversity. A Saliency-balancing Fusion mechanism is further proposed to enrich the informativeness by engaging the gradient information, guiding augmentation with proper orientation and magnitude. As an important contribution, we prove theoretically that our proposed augmentation can lead to an upper bound of the generalization risk on the unseen target domain, thus confirming our hypothesis. Combining the two strategies, our Saliency-balancing Location-scale Augmentation (SLAug) exceeds the state-of-the-art works by a large margin in two challenging SDG tasks. Code is available at https://github.com/Kaiseem/SLAug .

Mind The Gap: Alleviating Local Imbalance for Unsupervised Cross-Modality Medical Image Segmentation

Unsupervised cross-modality medical image adaptation aims to alleviate the severe domain gap between different imaging modalities without using the target domain label. A key in this campaign relies upon aligning the distributions of source and target domain. One common attempt is to enforce the global alignment between two domains, which, however, ignores the fatal local-imbalance domain gap problem, i.e., some local features with larger domain gap are harder to transfer. Recently, some methods conduct alignment focusing on local regions to improve the efficiency of model learning. While this operation may cause a deficiency of critical information from contexts. To tackle this limitation, we propose a novel strategy to alleviate the domain gap imbalance considering the characteristics of medical images, namely Global-Local Union Alignment. Specifically, a feature-disentanglement style-transfer module first synthesizes the target-like source-content images to reduce the global domain gap. Then, a local feature mask is integrated to reduce the 'inter-gap' for local features by prioritizing those discriminative features with larger domain gap. This combination of global and local alignment can precisely localize the crucial regions in segmentation target while preserving the overall semantic consistency. We conduct a series of experiments with two cross-modality adaptation tasks, i,e. cardiac substructure and abdominal multi-organ segmentation. Experimental results indicate that our method exceeds the SOTA methods by 3.92% Dice score in MRI-CT cardiac segmentation and 3.33% in the reverse direction.

CrossMoDA 2021 challenge: Benchmark of Cross-Modality Domain Adaptation techniques for Vestibular Schwnannoma and Cochlea Segmentation

Domain Adaptation (DA) has recently raised strong interests in the medical imaging community. While a large variety of DA techniques has been proposed for image segmentation, most of these techniques have been validated either on private datasets or on small publicly available datasets. Moreover, these datasets mostly addressed single-class problems. To tackle these limitations, the Cross-Modality Domain Adaptation (crossMoDA) challenge was organised in conjunction with the 24th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2021). CrossMoDA is the first large and multi-class benchmark for unsupervised cross-modality DA. The challenge's goal is to segment two key brain structures involved in the follow-up and treatment planning of vestibular schwannoma (VS): the VS and the cochleas. Currently, the diagnosis and surveillance in patients with VS are performed using contrast-enhanced T1 (ceT1) MRI. However, there is growing interest in using non-contrast sequences such as high-resolution T2 (hrT2) MRI. Therefore, we created an unsupervised cross-modality segmentation benchmark. The training set provides annotated ceT1 (N=105) and unpaired non-annotated hrT2 (N=105). The aim was to automatically perform unilateral VS and bilateral cochlea segmentation on hrT2 as provided in the testing set (N=137). A total of 16 teams submitted their algorithm for the evaluation phase. The level of performance reached by the top-performing teams is strikingly high (best median Dice - VS:88.4%; Cochleas:85.7%) and close to full supervision (median Dice - VS:92.5%; Cochleas:87.7%). All top-performing methods made use of an image-to-image translation approach to transform the source-domain images into pseudo-target-domain images. A segmentation network was then trained using these generated images and the manual annotations provided for the source image.