Cross-Shaped Windows Transformer with Self-supervised Pretraining for Clinically Significant Prostate Cancer Detection in Bi-parametric MRI

Multiparametric magnetic resonance imaging (mpMRI) has demonstrated promising results in prostate cancer (PCa) detection using deep convolutional neural networks (CNNs). Recently, transformers have achieved competitive performance compared to CNNs in computer vision. Large-scale transformers need abundant annotated data for training, which are difficult to obtain in medical imaging. Self-supervised learning can effectively leverage unlabeled data to extract useful semantic representations without annotation and its associated costs. This can improve model performance on downstream tasks with limited labelled data and increase generalizability. We introduce a novel end-to-end Cross-Shaped windows (CSwin) transformer UNet model, CSwin UNet, to detect clinically significant prostate cancer (csPCa) in prostate bi-parametric MR imaging (bpMRI) and demonstrate the effectiveness of our proposed self-supervised pre-training framework. Using a large prostate bpMRI dataset with 1500 patients, we first pre-train CSwin transformer using multi-task self-supervised learning to improve data-efficiency and network generalizability. We then finetuned using lesion annotations to perform csPCa detection. Five-fold cross validation shows that self-supervised CSwin UNet achieves 0.888 AUC and 0.545 Average Precision (AP), significantly outperforming four state-of-the-art models (Swin UNETR, DynUNet, Attention UNet, UNet). Using a separate bpMRI dataset with 158 patients, we evaluated our model robustness to external hold-out data. Self-supervised CSwin UNet achieves 0.79 AUC and 0.45 AP, still outperforming all other comparable methods and demonstrating generalization to a dataset shift.

Polyp-SAM: Transfer SAM for Polyp Segmentation

Colon polyps are considered important precursors for colorectal cancer. Automatic segmentation of colon polyps can significantly reduce the misdiagnosis of colon cancer and improve physician annotation efficiency. While many methods have been proposed for polyp segmentation, training large-scale segmentation networks with limited colonoscopy data remains a challenge. Recently, the Segment Anything Model (SAM) has recently gained much attention in both natural and medical image segmentation. SAM demonstrates superior performance in several image benchmarks and therefore shows great potential for medical image segmentation. In this study, we propose Poly-SAM, a finetuned SAM model for polyp segmentation, and compare its performance to several state-of-the-art polyp segmentation models. We also compare two transfer learning strategies of SAM with and without finetuning its encoders. Evaluated on five public datasets, our Polyp-SAM achieves state-of-the-art performance on two datasets and impressive performance on three datasets, with dice scores all above 88%. This study demonstrates the great potential of adapting SAM to medical image segmentation tasks. We plan to release the code and model weights for this paper at: https://github.com/ricklisz/Polyp-SAM.

SkinSAM: Empowering Skin Cancer Segmentation with Segment Anything Model

Skin cancer is a prevalent and potentially fatal disease that requires accurate and efficient diagnosis and treatment. Although manual tracing is the current standard in clinics, automated tools are desired to reduce human labor and improve accuracy. However, developing such tools is challenging due to the highly variable appearance of skin cancers and complex objects in the background. In this paper, we present SkinSAM, a fine-tuned model based on the Segment Anything Model that showed outstanding segmentation performance. The models are validated on HAM10000 dataset which includes 10015 dermatoscopic images. While larger models (ViT_L, ViT_H) performed better than the smaller one (ViT_b), the finetuned model (ViT_b_finetuned) exhibited the greatest improvement, with a Mean pixel accuracy of 0.945, Mean dice score of 0.8879, and Mean IoU score of 0.7843. Among the lesion types, vascular lesions showed the best segmentation results. Our research demonstrates the great potential of adapting SAM to medical image segmentation tasks.

Advancing Medical Imaging with Language Models: A Journey from N-grams to ChatGPT

In this paper, we aimed to provide a review and tutorial for researchers in the field of medical imaging using language models to improve their tasks at hand. We began by providing an overview of the history and concepts of language models, with a special focus on large language models. We then reviewed the current literature on how language models are being used to improve medical imaging, emphasizing different applications such as image captioning, report generation, report classification, finding extraction, visual question answering, interpretable diagnosis, and more for various modalities and organs. The ChatGPT was specially highlighted for researchers to explore more potential applications. We covered the potential benefits of accurate and efficient language models for medical imaging analysis, including improving clinical workflow efficiency, reducing diagnostic errors, and assisting healthcare professionals in providing timely and accurate diagnoses. Overall, our goal was to bridge the gap between language models and medical imaging and inspire new ideas and innovations in this exciting area of research. We hope that this review paper will serve as a useful resource for researchers in this field and encourage further exploration of the possibilities of language models in medical imaging.

Practical and Ethical Challenges of Large Language Models in Education: A Systematic Literature Review

Educational technology innovations that have been developed based on large language models (LLMs) have shown the potential to automate the laborious process of generating and analysing textual content. While various innovations have been developed to automate a range of educational tasks (e.g., question generation, feedback provision, and essay grading), there are concerns regarding the practicality and ethicality of these innovations. Such concerns may hinder future research and the adoption of LLMs-based innovations in authentic educational contexts. To address this, we conducted a systematic literature review of 118 peer-reviewed papers published since 2017 to pinpoint the current state of research on using LLMs to automate and support educational tasks. The practical and ethical challenges of LLMs-based innovations were also identified by assessing their technological readiness, model performance, replicability, system transparency, privacy, equality, and beneficence. The findings were summarised into three recommendations for future studies, including updating existing innovations with state-of-the-art models (e.g., GPT-3), embracing the initiative of open-sourcing models/systems, and adopting a human-centred approach throughout the developmental process. These recommendations could support future research to develop practical and ethical innovations for supporting diverse educational tasks and benefiting students, teachers, and institutions.

Towards Universal Fake Image Detectors that Generalize Across Generative Models

With generative models proliferating at a rapid rate, there is a growing need for general purpose fake image detectors. In this work, we first show that the existing paradigm, which consists of training a deep network for real-vs-fake classification, fails to detect fake images from newer breeds of generative models when trained to detect GAN fake images. Upon analysis, we find that the resulting classifier is asymmetrically tuned to detect patterns that make an image fake. The real class becomes a sink class holding anything that is not fake, including generated images from models not accessible during training. Building upon this discovery, we propose to perform real-vs-fake classification without learning; i.e., using a feature space not explicitly trained to distinguish real from fake images. We use nearest neighbor and linear probing as instantiations of this idea. When given access to the feature space of a large pretrained vision-language model, the very simple baseline of nearest neighbor classification has surprisingly good generalization ability in detecting fake images from a wide variety of generative models; e.g., it improves upon the SoTA by +15.07 mAP and +25.90% acc when tested on unseen diffusion and autoregressive models.

GLIGEN: Open-Set Grounded Text-to-Image Generation

Large-scale text-to-image diffusion models have made amazing advances. However, the status quo is to use text input alone, which can impede controllability. In this work, we propose GLIGEN, Grounded-Language-to-Image Generation, a novel approach that builds upon and extends the functionality of existing pre-trained text-to-image diffusion models by enabling them to also be conditioned on grounding inputs. To preserve the vast concept knowledge of the pre-trained model, we freeze all of its weights and inject the grounding information into new trainable layers via a gated mechanism. Our model achieves open-world grounded text2img generation with caption and bounding box condition inputs, and the grounding ability generalizes well to novel spatial configuration and concepts. GLIGEN's zero-shot performance on COCO and LVIS outperforms that of existing supervised layout-to-image baselines by a large margin.

Contrastive Learning for Diverse Disentangled Foreground Generation

We introduce a new method for diverse foreground generation with explicit control over various factors. Existing image inpainting based foreground generation methods often struggle to generate diverse results and rarely allow users to explicitly control specific factors of variation (e.g., varying the facial identity or expression for face inpainting results). We leverage contrastive learning with latent codes to generate diverse foreground results for the same masked input. Specifically, we define two sets of latent codes, where one controls a pre-defined factor (``known''), and the other controls the remaining factors (``unknown''). The sampled latent codes from the two sets jointly bi-modulate the convolution kernels to guide the generator to synthesize diverse results. Experiments demonstrate the superiority of our method over state-of-the-arts in result diversity and generation controllability.

What Knowledge Gets Distilled in Knowledge Distillation?

Knowledge distillation aims to transfer useful information from a teacher network to a student network, with the primary goal of improving the student's performance for the task at hand. Over the years, there has a been a deluge of novel techniques and use cases of knowledge distillation. Yet, despite the various improvements, there seems to be a glaring gap in the community's fundamental understanding of the process. Specifically, what is the knowledge that gets distilled in knowledge distillation? In other words, in what ways does the student become similar to the teacher? Does it start to localize objects in the same way? Does it get fooled by the same adversarial samples? Does its data invariance properties become similar? Our work presents a comprehensive study to try to answer these questions and more. Our results, using image classification as a case study and three state-of-the-art knowledge distillation techniques, show that knowledge distillation methods can indeed indirectly distill other kinds of properties beyond improving task performance. By exploring these questions, we hope for our work to provide a clearer picture of what happens during knowledge distillation.

GIRAFFE HD: A High-Resolution 3D-aware Generative Model

3D-aware generative models have shown that the introduction of 3D information can lead to more controllable image generation. In particular, the current state-of-the-art model GIRAFFE can control each object's rotation, translation, scale, and scene camera pose without corresponding supervision. However, GIRAFFE only operates well when the image resolution is low. We propose GIRAFFE HD, a high-resolution 3D-aware generative model that inherits all of GIRAFFE's controllable features while generating high-quality, high-resolution images ($512^2$ resolution and above). The key idea is to leverage a style-based neural renderer, and to independently generate the foreground and background to force their disentanglement while imposing consistency constraints to stitch them together to composite a coherent final image. We demonstrate state-of-the-art 3D controllable high-resolution image generation on multiple natural image datasets.