Continual Pretraining on Encrypted Synthetic Data for Privacy-Preserving LLMs

Preserving privacy in sensitive data while pretraining large language models on small, domain-specific corpora presents a significant challenge. In this work, we take an exploratory step toward privacy-preserving continual pretraining by proposing an entity-based framework that synthesizes encrypted training data to protect personally identifiable information (PII). Our approach constructs a weighted entity graph to guide data synthesis and applies deterministic encryption to PII entities, enabling LLMs to encode new knowledge through continual pretraining while granting authorized access to sensitive data through decryption keys. Our results on limited-scale datasets demonstrate that our pretrained models outperform base models and ensure PII security, while exhibiting a modest performance gap compared to models trained on unencrypted synthetic data. We further show that increasing the number of entities and leveraging graph-based synthesis improves model performance, and that encrypted models retain instruction-following capabilities with long retrieved contexts. We discuss the security implications and limitations of deterministic encryption, positioning this work as an initial investigation into the design space of encrypted data pretraining for privacy-preserving LLMs. Our code is available at https://github.com/DataArcTech/SoE.

GaussianEM: Model compositional and conformational heterogeneity using 3D Gaussians

Understanding protein flexibility and its dynamic interactions with other molecules is essential for protein function study. Cryogenic electron microscopy (cryo-EM) provides an opportunity to directly observe macromolecular dynamics. However, analyzing datasets that contain both continuous motions and discrete states remains highly challenging. Here we present GaussianEM, a Gaussian pseudo-atomic framework that simultaneously models compositional and conformational heterogeneity from experimental cryo-EM images. GaussianEM employs a two-encoder-one-decoder architecture to map an image to its individual Gaussian components, and represent structural variability through changes in Gaussian parameters. This approach provides an intuitive and interpretable description of conformational changes, preserves local structural consistency along the transition trajectories, and naturally bridges the gap between density-based models and corresponding atomic models. We demonstrate the effectiveness of GaussianEM on both simulated and experimental datasets.