ECG-MoE: Mixture-of-Expert Electrocardiogram Foundation Model

Electrocardiography (ECG) analysis is crucial for cardiac diagnosis, yet existing foundation models often fail to capture the periodicity and diverse features required for varied clinical tasks. We propose ECG-MoE, a hybrid architecture that integrates multi-model temporal features with a cardiac period-aware expert module. Our approach uses a dual-path Mixture-of-Experts to separately model beat-level morphology and rhythm, combined with a hierarchical fusion network using LoRA for efficient inference. Evaluated on five public clinical tasks, ECG-MoE achieves state-of-the-art performance with 40% faster inference than multi-task baselines.

Position: General Alignment Has Hit a Ceiling; Edge Alignment Must Be Taken Seriously

Large language models are being deployed in complex socio-technical systems, which exposes limits in current alignment practice. We take the position that the dominant paradigm of General Alignment, which compresses diverse human values into a single scalar reward, reaches a structural ceiling in settings with conflicting values, plural stakeholders, and irreducible uncertainty. These failures follow from the mathematics and incentives of scalarization and lead to \textbf{structural} value flattening, \textbf{normative} representation loss, and \textbf{cognitive} uncertainty blindness. We introduce Edge Alignment as a distinct approach in which systems preserve multi dimensional value structure, support plural and democratic representation, and incorporate epistemic mechanisms for interaction and clarification. To make this approach practical, we propose seven interdependent pillars organized into three phases. We identify key challenges in data collection, training objectives, and evaluation, outlining complementary technical and governance directions. Taken together, these measures reframe alignment as a lifecycle problem of dynamic normative governance rather than as a single instance optimization task.

Simulator and Experience Enhanced Diffusion Model for Comprehensive ECG Generation

Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Electrocardiograms (ECGs) are the most widely used non-invasive tool for cardiac assessment, yet large, well-annotated ECG corpora are scarce due to cost, privacy, and workflow constraints. Generating ECGs can be beneficial for the mechanistic understanding of cardiac electrical activity, enable the construction of large, heterogeneous, and unbiased datasets, and facilitate privacy-preserving data sharing. Generating realistic ECG signals from clinical context is important yet underexplored. Recent work has leveraged diffusion models for text-to-ECG generation, but two challenges remain: (i) existing methods often overlook the physiological simulator knowledge of cardiac activity; and (ii) they ignore broader, experience-based clinical knowledge grounded in real-world practice. To address these gaps, we propose SE-Diff, a novel physiological simulator and experience enhanced diffusion model for comprehensive ECG generation. SE-Diff integrates a lightweight ordinary differential equation (ODE)-based ECG simulator into the diffusion process via a beat decoder and simulator-consistent constraints, injecting mechanistic priors that promote physiologically plausible waveforms. In parallel, we design an LLM-powered experience retrieval-augmented strategy to inject clinical knowledge, providing more guidance for ECG generation. Extensive experiments on real-world ECG datasets demonstrate that SE-Diff improves both signal fidelity and text-ECG semantic alignment over baselines, proving its superiority for text-to-ECG generation. We further show that the simulator-based and experience-based knowledge also benefit downstream ECG classification.

Conditional Neural ODE for Longitudinal Parkinson's Disease Progression Forecasting

Parkinson's disease (PD) shows heterogeneous, evolving brain-morphometry patterns. Modeling these longitudinal trajectories enables mechanistic insight, treatment development, and individualized 'digital-twin' forecasting. However, existing methods usually adopt recurrent neural networks and transformer architectures, which rely on discrete, regularly sampled data while struggling to handle irregular and sparse magnetic resonance imaging (MRI) in PD cohorts. Moreover, these methods have difficulty capturing individual heterogeneity including variations in disease onset, progression rate, and symptom severity, which is a hallmark of PD. To address these challenges, we propose CNODE (Conditional Neural ODE), a novel framework for continuous, individualized PD progression forecasting. The core of CNODE is to model morphological brain changes as continuous temporal processes using a neural ODE model. In addition, we jointly learn patient-specific initial time and progress speed to align individual trajectories into a shared progression trajectory. We validate CNODE on the Parkinson's Progression Markers Initiative (PPMI) dataset. Experimental results show that our method outperforms state-of-the-art baselines in forecasting longitudinal PD progression.

Graph ODEs and Beyond: A Comprehensive Survey on Integrating Differential Equations with Graph Neural Networks

Graph Neural Networks (GNNs) and differential equations (DEs) are two rapidly advancing areas of research that have shown remarkable synergy in recent years. GNNs have emerged as powerful tools for learning on graph-structured data, while differential equations provide a principled framework for modeling continuous dynamics across time and space. The intersection of these fields has led to innovative approaches that leverage the strengths of both, enabling applications in physics-informed learning, spatiotemporal modeling, and scientific computing. This survey aims to provide a comprehensive overview of the burgeoning research at the intersection of GNNs and DEs. We will categorize existing methods, discuss their underlying principles, and highlight their applications across domains such as molecular modeling, traffic prediction, and epidemic spreading. Furthermore, we identify open challenges and outline future research directions to advance this interdisciplinary field. A comprehensive paper list is provided at https://github.com/Emory-Melody/Awesome-Graph-NDEs. This survey serves as a resource for researchers and practitioners seeking to understand and contribute to the fusion of GNNs and DEs

Couler: Unified Machine Learning Workflow Optimization in Cloud

Machine Learning (ML) has become ubiquitous, fueling data-driven applications across various organizations. Contrary to the traditional perception of ML in research, ML workflows can be complex, resource-intensive, and time-consuming. Expanding an ML workflow to encompass a wider range of data infrastructure and data types may lead to larger workloads and increased deployment costs. Currently, numerous workflow engines are available (with over ten being widely recognized). This variety poses a challenge for end-users in terms of mastering different engine APIs. While efforts have primarily focused on optimizing ML Operations (MLOps) for a specific workflow engine, current methods largely overlook workflow optimization across different engines. In this work, we design and implement Couler, a system designed for unified ML workflow optimization in the cloud. Our main insight lies in the ability to generate an ML workflow using natural language (NL) descriptions. We integrate Large Language Models (LLMs) into workflow generation, and provide a unified programming interface for various workflow engines. This approach alleviates the need to understand various workflow engines' APIs. Moreover, Couler enhances workflow computation efficiency by introducing automated caching at multiple stages, enabling large workflow auto-parallelization and automatic hyperparameters tuning. These enhancements minimize redundant computational costs and improve fault tolerance during deep learning workflow training. Couler is extensively deployed in real-world production scenarios at Ant Group, handling approximately 22k workflows daily, and has successfully improved the CPU/Memory utilization by more than 15% and the workflow completion rate by around 17%.