RareLens: Towards End-to-End Rare Disease Care via Aligning Divergent Large Language Model Reasoning

Rare diseases collectively affect an estimated 3.5% to 5.9% of the population, yet more than 70% of patients are misdiagnosed and many endure years of evaluation before a diagnosis is reached, because early presentations are nonspecific and relevant expertise is scarce and unevenly distributed. Artificial intelligence could provide support, but existing systems address isolated stages of care, overwhelmingly diagnosis. They typically depend on the results of downstream investigations, and they treat the variability between models as noise to be eliminated. Here we present RareLens, a system that supports clinical decision-making across the entire rare disease trajectory by exploiting this variability. When heterogeneous large language models evaluate the same case, they generate divergent but complementary reasoning, which RareLens aligns and calibrates into a single convergent, actionable decision at each stage. Four coordinated modules perform primary-visit risk screening, diagnosis, treatment planning and prognosis. Developed and evaluated on RareBench, a real-world dataset of 157,525 cases spanning all 33 Orphanet categories and more than 7,000 conditions, RareLens outperformed every frontier model tested, including GPT-5, DeepSeek-R1, Claude-3.7-Sonnet and Gemini-2.5-Pro, at each stage. It achieved an area under the curve of 0.917 for screening and top-1 accuracies of 65.5% and 89.8% for diagnosis and treatment. In an external study spanning 1,287 cases and 23 physicians, autonomous RareLens and physicians assisted by RareLens both substantially outperformed unaided physicians. These findings indicate that aligning divergent model reasoning, rather than scaling a single model, offers a generalizable strategy for high-uncertainty clinical decision-making.

SWE-Together: Evaluating Coding Agents in Interactive User Sessions

Most coding-agent benchmarks are static: an agent receives a complete task description up front and is judged only by its final code. Real coding assistance is interactive, with users clarifying goals, adding constraints, and correcting mistakes over multiple turns. We introduce SWE-Together, a multi-turn benchmark reconstructed from real user-agent coding sessions. To make real interactions verifiable, we curate 109 repository-level tasks from 11,260 recorded sessions, selecting sessions with recoverable repository states, clear user goals, and observable outcomes. To replay these interactions across agents, we build a reactive LLM-based user simulator that preserves the original users' intents and provides feedback when the coding agent's progress requires it. To evaluate agents as collaborators, we measure both final repository correctness and the number of corrective feedback turns required during the interaction. Experiments with frontier coding agents show that stronger agents generally achieve higher final success rates while requiring fewer interventions, suggesting an improved user experience.

The Courtroom Trial of Pixels: Robust Image Manipulation Localization via Adversarial Evidence and Reinforcement Learning Judgment

Although some existing image manipulation localization (IML) methods incorporate authenticity-related supervision, this information is typically utilized merely as an auxiliary training signal to enhance the model's sensitivity to manipulation artifacts, rather than being explicitly modeled as localization evidence opposing the manipulated regions. Consequently, when manipulation traces are subtle or degraded by post-processing and noise, these methods struggle to explicitly compare manipulated and authentic evidence, resulting in unreliable predictions in ambiguous areas. To address these issues, we propose a courtroom-style adjudication framework that regards IML task as the confrontation of evidence followed by judgment. The framework comprises a prosecution stream, a defense stream, and a judge model. We first build a dual-hypothesis segmentation architecture on a shared multi-scale encoder, in which the prosecution stream asserts manipulation and the defense stream asserts authenticity. Guided by edge priors, it produces evidence for manipulated and authentic regions through cascaded multi-level fusion, bidirectional disagreement suppression, and dynamic debate refinement. We further develop a reinforcement learning judge model that performs strategic re-inference and refinement on uncertain regions, yielding a manipulated-region mask. The judge model is trained with advantage-based rewards and a soft-IoU objective, and reliability is calibrated via entropy and cross-hypothesis consistency. Experimental results show that our model achieves superior average performance compared with SOTA IML methods.

Beyond Single-Sample: Reliable Multi-Sample Distillation for Video Understanding

Traditional black-box distillation for Large Vision-Language Models (LVLMs) typically relies on a single teacher response per input, which often yields high-variance responses and format inconsistencies in multimodal or temporal scenarios. To mitigate this unreliable supervision, we propose R-MSD (Reliable Multi-Sample Distillation), a framework that explicitly models teacher sampling variance to enhance distillation stability. Rather than relying on a single teacher response, our approach leverages a task-adaptive teacher pool to provide robust supervision tailored to both closed-ended and open-ended reasoning. By integrating quality-aware signal matching with an adversarial distillation objective, our approach effectively filters teacher noise while maximizing knowledge transfer. Extensive evaluations across comprehensive video understanding benchmarks demonstrate that R-MSD consistently outperforms single sample distillation methods. We additionally include an original SFT+RL 4B baseline under the same training budget, which shows only marginal gains, while our method achieves significant improvements. With a 4B student model, our approach delivers gains on VideoMME (+1.5%), Video-MMMU (+3.2%), and MathVerse (+3.6%).

SkillsBench: Benchmarking How Well Agent Skills Work Across Diverse Tasks

Agent Skills are structured packages of procedural knowledge that augment LLM agents at inference time. Despite rapid adoption, there is no standard way to measure whether they actually help. We present SkillsBench, a benchmark of 86 tasks across 11 domains paired with curated Skills and deterministic verifiers. Each task is evaluated under three conditions: no Skills, curated Skills, and self-generated Skills. We test 7 agent-model configurations over 7,308 trajectories. Curated Skills raise average pass rate by 16.2 percentage points(pp), but effects vary widely by domain (+4.5pp for Software Engineering to +51.9pp for Healthcare) and 16 of 84 tasks show negative deltas. Self-generated Skills provide no benefit on average, showing that models cannot reliably author the procedural knowledge they benefit from consuming. Focused Skills with 2--3 modules outperform comprehensive documentation, and smaller models with Skills can match larger models without them.

The Llama 4 Herd: Architecture, Training, Evaluation, and Deployment Notes

This document consolidates publicly reported technical details about Metas Llama 4 model family. It summarizes (i) released variants (Scout and Maverick) and the broader herd context including the previewed Behemoth teacher model, (ii) architectural characteristics beyond a high-level MoE description covering routed/shared-expert structure, early-fusion multimodality, and long-context design elements reported for Scout (iRoPE and length generalization strategies), (iii) training disclosures spanning pre-training, mid-training for long-context extension, and post-training methodology (lightweight SFT, online RL, and lightweight DPO) as described in release materials, (iv) developer-reported benchmark results for both base and instruction-tuned checkpoints, and (v) practical deployment constraints observed across major serving environments, including provider-specific context limits and quantization packaging. The manuscript also summarizes licensing obligations relevant to redistribution and derivative naming, and reviews publicly described safeguards and evaluation practices. The goal is to provide a compact technical reference for researchers and practitioners who need precise, source-backed facts about Llama 4.

Rubric-Based Benchmarking and Reinforcement Learning for Advancing LLM Instruction Following

Recent progress in large language models (LLMs) has led to impressive performance on a range of tasks, yet advanced instruction following (IF)-especially for complex, multi-turn, and system-prompted instructions-remains a significant challenge. Rigorous evaluation and effective training for such capabilities are hindered by the lack of high-quality, human-annotated benchmarks and reliable, interpretable reward signals. In this work, we introduce AdvancedIF (we will release this benchmark soon), a comprehensive benchmark featuring over 1,600 prompts and expert-curated rubrics that assess LLMs ability to follow complex, multi-turn, and system-level instructions. We further propose RIFL (Rubric-based Instruction-Following Learning), a novel post-training pipeline that leverages rubric generation, a finetuned rubric verifier, and reward shaping to enable effective reinforcement learning for instruction following. Extensive experiments demonstrate that RIFL substantially improves the instruction-following abilities of LLMs, achieving a 6.7% absolute gain on AdvancedIF and strong results on public benchmarks. Our ablation studies confirm the effectiveness of each component in RIFL. This work establishes rubrics as a powerful tool for both training and evaluating advanced IF in LLMs, paving the way for more capable and reliable AI systems.

Large Model Empowered Embodied AI: A Survey on Decision-Making and Embodied Learning

Embodied AI aims to develop intelligent systems with physical forms capable of perceiving, decision-making, acting, and learning in real-world environments, providing a promising way to Artificial General Intelligence (AGI). Despite decades of explorations, it remains challenging for embodied agents to achieve human-level intelligence for general-purpose tasks in open dynamic environments. Recent breakthroughs in large models have revolutionized embodied AI by enhancing perception, interaction, planning and learning. In this article, we provide a comprehensive survey on large model empowered embodied AI, focusing on autonomous decision-making and embodied learning. We investigate both hierarchical and end-to-end decision-making paradigms, detailing how large models enhance high-level planning, low-level execution, and feedback for hierarchical decision-making, and how large models enhance Vision-Language-Action (VLA) models for end-to-end decision making. For embodied learning, we introduce mainstream learning methodologies, elaborating on how large models enhance imitation learning and reinforcement learning in-depth. For the first time, we integrate world models into the survey of embodied AI, presenting their design methods and critical roles in enhancing decision-making and learning. Though solid advances have been achieved, challenges still exist, which are discussed at the end of this survey, potentially as the further research directions.

Bridging Semantic Logic Gaps: A Cognition-Inspired Multimodal Boundary-Preserving Network for Image Manipulation Localization

The existing image manipulation localization (IML) models mainly relies on visual cues, but ignores the semantic logical relationships between content features. In fact, the content semantics conveyed by real images often conform to human cognitive laws. However, image manipulation technology usually destroys the internal relationship between content features, thus leaving semantic clues for IML. In this paper, we propose a cognition-inspired multimodal boundary-preserving network (CMB-Net). Specifically, CMB-Net utilizes large language models (LLMs) to analyze manipulated regions within images and generate prompt-based textual information to compensate for the lack of semantic relationships in the visual information. Considering that the erroneous texts induced by hallucination from LLMs will damage the accuracy of IML, we propose an image-text central ambiguity module (ITCAM). It assigns weights to the text features by quantifying the ambiguity between text and image features, thereby ensuring the beneficial impact of textual information. We also propose an image-text interaction module (ITIM) that aligns visual and text features using a correlation matrix for fine-grained interaction. Finally, inspired by invertible neural networks, we propose a restoration edge decoder (RED) that mutually generates input and output features to preserve boundary information in manipulated regions without loss. Extensive experiments show that CMB-Net outperforms most existing IML models.

Beyond Fully Supervised Pixel Annotations: Scribble-Driven Weakly-Supervised Framework for Image Manipulation Localization

Deep learning-based image manipulation localization (IML) methods have achieved remarkable performance in recent years, but typically rely on large-scale pixel-level annotated datasets. To address the challenge of acquiring high-quality annotations, some recent weakly supervised methods utilize image-level labels to segment manipulated regions. However, the performance is still limited due to insufficient supervision signals. In this study, we explore a form of weak supervision that improves the annotation efficiency and detection performance, namely scribble annotation supervision. We re-annotated mainstream IML datasets with scribble labels and propose the first scribble-based IML (Sc-IML) dataset. Additionally, we propose the first scribble-based weakly supervised IML framework. Specifically, we employ self-supervised training with a structural consistency loss to encourage the model to produce consistent predictions under multi-scale and augmented inputs. In addition, we propose a prior-aware feature modulation module (PFMM) that adaptively integrates prior information from both manipulated and authentic regions for dynamic feature adjustment, further enhancing feature discriminability and prediction consistency in complex scenes. We also propose a gated adaptive fusion module (GAFM) that utilizes gating mechanisms to regulate information flow during feature fusion, guiding the model toward emphasizing potential tampered regions. Finally, we propose a confidence-aware entropy minimization loss (${\mathcal{L}}_{ {CEM }}$). This loss dynamically regularizes predictions in weakly annotated or unlabeled regions based on model uncertainty, effectively suppressing unreliable predictions. Experimental results show that our method outperforms existing fully supervised approaches in terms of average performance both in-distribution and out-of-distribution.