Early prediction of onset of sepsis in Clinical Setting

This study proposes the use of Machine Learning models to predict the early onset of sepsis using deidentified clinical data from Montefiore Medical Center in Bronx, NY, USA. A supervised learning approach was adopted, wherein an XGBoost model was trained utilizing 80\% of the train dataset, encompassing 107 features (including the original and derived features). Subsequently, the model was evaluated on the remaining 20\% of the test data. The model was validated on prospective data that was entirely unseen during the training phase. To assess the model's performance at the individual patient level and timeliness of the prediction, a normalized utility score was employed, a widely recognized scoring methodology for sepsis detection, as outlined in the PhysioNet Sepsis Challenge paper. Metrics such as F1 Score, Sensitivity, Specificity, and Flag Rate were also devised. The model achieved a normalized utility score of 0.494 on test data and 0.378 on prospective data at threshold 0.3. The F1 scores were 80.8\% and 67.1\% respectively for the test data and the prospective data for the same threshold, highlighting its potential to be integrated into clinical decision-making processes effectively. These results bear testament to the model's robust predictive capabilities and its potential to substantially impact clinical decision-making processes.

MotifClass: Weakly Supervised Text Classification with Higher-order Metadata Information

We study the problem of weakly supervised text classification, which aims to classify text documents into a set of pre-defined categories with category surface names only and without any annotated training document provided. Most existing approaches leverage textual information in each document. However, in many domains, documents are accompanied by various types of metadata (e.g., authors, venue, and year of a research paper). These metadata and their combinations may serve as strong category indicators in addition to textual contents. In this paper, we explore the potential of using metadata to help weakly supervised text classification. To be specific, we model the relationships between documents and metadata via a heterogeneous information network. To effectively capture higher-order structures in the network, we use motifs to describe metadata combinations. We propose a novel framework, named MotifClass, which (1) selects category-indicative motif instances, (2) retrieves and generates pseudo-labeled training samples based on category names and indicative motif instances, and (3) trains a text classifier using the pseudo training data. Extensive experiments on real-world datasets demonstrate the superior performance of MotifClass to existing weakly supervised text classification approaches. Further analysis shows the benefit of considering higher-order metadata information in our framework.