A Clinical-oriented Multi-level Contrastive Learning Method for Disease Diagnosis in Low-quality Medical Images

Representation learning offers a conduit to elucidate distinctive features within the latent space and interpret the deep models. However, the randomness of lesion distribution and the complexity of low-quality factors in medical images pose great challenges for models to extract key lesion features. Disease diagnosis methods guided by contrastive learning (CL) have shown significant advantages in lesion feature representation. Nevertheless, the effectiveness of CL is highly dependent on the quality of the positive and negative sample pairs. In this work, we propose a clinical-oriented multi-level CL framework that aims to enhance the model's capacity to extract lesion features and discriminate between lesion and low-quality factors, thereby enabling more accurate disease diagnosis from low-quality medical images. Specifically, we first construct multi-level positive and negative pairs to enhance the model's comprehensive recognition capability of lesion features by integrating information from different levels and qualities of medical images. Moreover, to improve the quality of the learned lesion embeddings, we introduce a dynamic hard sample mining method based on self-paced learning. The proposed CL framework is validated on two public medical image datasets, EyeQ and Chest X-ray, demonstrating superior performance compared to other state-of-the-art disease diagnostic methods.

HRLAIF: Improvements in Helpfulness and Harmlessness in Open-domain Reinforcement Learning From AI Feedback

Reinforcement Learning from AI Feedback (RLAIF) has the advantages of shorter annotation cycles and lower costs over Reinforcement Learning from Human Feedback (RLHF), making it highly efficient during the rapid strategy iteration periods of large language model (LLM) training. Using ChatGPT as a labeler to provide feedback on open-domain prompts in RLAIF training, we observe an increase in human evaluators' preference win ratio for model responses, but a decrease in evaluators' satisfaction rate. Analysis suggests that the decrease in satisfaction rate is mainly due to some responses becoming less helpful, particularly in terms of correctness and truthfulness, highlighting practical limitations of basic RLAIF. In this paper, we propose Hybrid Reinforcement Learning from AI Feedback (HRLAIF). This method enhances the accuracy of AI annotations for responses, making the model's helpfulness more robust in training process. Additionally, it employs AI for Red Teaming, further improving the model's harmlessness. Human evaluation results show that HRLAIF inherits the ability of RLAIF to enhance human preference for outcomes at a low cost while also improving the satisfaction rate of responses. Compared to the policy model before Reinforcement Learning (RL), it achieves an increase of 2.08\% in satisfaction rate, effectively addressing the issue of a decrease of 4.58\% in satisfaction rate after basic RLAIF.

Narrowing the semantic gaps in U-Net with learnable skip connections: The case of medical image segmentation

Most state-of-the-art methods for medical image segmentation adopt the encoder-decoder architecture. However, this U-shaped framework still has limitations in capturing the non-local multi-scale information with a simple skip connection. To solve the problem, we firstly explore the potential weakness of skip connections in U-Net on multiple segmentation tasks, and find that i) not all skip connections are useful, each skip connection has different contribution; ii) the optimal combinations of skip connections are different, relying on the specific datasets. Based on our findings, we propose a new segmentation framework, named UDTransNet, to solve three semantic gaps in U-Net. Specifically, we propose a Dual Attention Transformer (DAT) module for capturing the channel- and spatial-wise relationships to better fuse the encoder features, and a Decoder-guided Recalibration Attention (DRA) module for effectively connecting the DAT tokens and the decoder features to eliminate the inconsistency. Hence, both modules establish a learnable connection to solve the semantic gaps between the encoder and the decoder, which leads to a high-performance segmentation model for medical images. Comprehensive experimental results indicate that our UDTransNet produces higher evaluation scores and finer segmentation results with relatively fewer parameters over the state-of-the-art segmentation methods on different public datasets. Code: https://github.com/McGregorWwww/UDTransNet.

Self-supervised Domain Adaptation for Breaking the Limits of Low-quality Fundus Image Quality Enhancement

Retinal fundus images have been applied for the diagnosis and screening of eye diseases, such as Diabetic Retinopathy (DR) or Diabetic Macular Edema (DME). However, both low-quality fundus images and style inconsistency potentially increase uncertainty in the diagnosis of fundus disease and even lead to misdiagnosis by ophthalmologists. Most of the existing image enhancement methods mainly focus on improving the image quality by leveraging the guidance of high-quality images, which is difficult to be collected in medical applications. In this paper, we tackle image quality enhancement in a fully unsupervised setting, i.e., neither paired images nor high-quality images. To this end, we explore the potential of the self-supervised task for improving the quality of fundus images without the requirement of high-quality reference images. Specifically, we construct multiple patch-wise domains via an auxiliary pre-trained quality assessment network and a style clustering. To achieve robust low-quality image enhancement and address style inconsistency, we formulate two self-supervised domain adaptation tasks to disentangle the features of image content, low-quality factor and style information by exploring intrinsic supervision signals within the low-quality images. Extensive experiments are conducted on EyeQ and Messidor datasets, and results show that our DASQE method achieves new state-of-the-art performance when only low-quality images are available.

Co-training with High-Confidence Pseudo Labels for Semi-supervised Medical Image Segmentation

High-quality pseudo labels are essential for semi-supervised semantic segmentation. Consistency regularization and pseudo labeling-based semi-supervised methods perform co-training using the pseudo labels from multi-view inputs. However, such co-training models tend to converge early to a consensus during training, so that the models degenerate to the self-training ones. Besides, the multi-view inputs are generated by perturbing or augmenting the original images, which inevitably introduces noise into the input leading to low-confidence pseudo labels. To address these issues, we propose an \textbf{U}ncertainty-guided Collaborative Mean-Teacher (UCMT) for semi-supervised semantic segmentation with the high-confidence pseudo labels. Concretely, UCMT consists of two main components: 1) collaborative mean-teacher (CMT) for encouraging model disagreement and performing co-training between the sub-networks, and 2) uncertainty-guided region mix (UMIX) for manipulating the input images according to the uncertainty maps of CMT and facilitating CMT to produce high-confidence pseudo labels. Combining the strengths of UMIX with CMT, UCMT can retain model disagreement and enhance the quality of pseudo labels for the co-training segmentation. Extensive experiments on four public medical image datasets including 2D and 3D modalities demonstrate the superiority of UCMT over the state-of-the-art. Code is available at: https://github.com/Senyh/UCMT.

Edge Enhanced Image Style Transfer via Transformers

In recent years, arbitrary image style transfer has attracted more and more attention. Given a pair of content and style images, a stylized one is hoped that retains the content from the former while catching style patterns from the latter. However, it is difficult to simultaneously keep well the trade-off between the content details and the style features. To stylize the image with sufficient style patterns, the content details may be damaged and sometimes the objects of images can not be distinguished clearly. For this reason, we present a new transformer-based method named STT for image style transfer and an edge loss which can enhance the content details apparently to avoid generating blurred results for excessive rendering on style features. Qualitative and quantitative experiments demonstrate that STT achieves comparable performance to state-of-the-art image style transfer methods while alleviating the content leak problem.

Contactless Oxygen Monitoring with Gated Transformer

With the increasing popularity of telehealth, it becomes critical to ensure that basic physiological signals can be monitored accurately at home, with minimal patient overhead. In this paper, we propose a contactless approach for monitoring patients' blood oxygen at home, simply by analyzing the radio signals in the room, without any wearable devices. We extract the patients' respiration from the radio signals that bounce off their bodies and devise a novel neural network that infers a patient's oxygen estimates from their breathing signal. Our model, called \emph{Gated BERT-UNet}, is designed to adapt to the patient's medical indices (e.g., gender, sleep stages). It has multiple predictive heads and selects the most suitable head via a gate controlled by the person's physiological indices. Extensive empirical results show that our model achieves high accuracy on both medical and radio datasets.

Generalized Deep Learning-based Proximal Gradient Descent for MR Reconstruction

The data consistency for the physical forward model is crucial in inverse problems, especially in MR imaging reconstruction. The standard way is to unroll an iterative algorithm into a neural network with a forward model embedded. The forward model always changes in clinical practice, so the learning component's entanglement with the forward model makes the reconstruction hard to generalize. The proposed method is more generalizable for different MR acquisition settings by separating the forward model from the deep learning component. The deep learning-based proximal gradient descent was proposed to create a learned regularization term independent of the forward model. We applied the one-time trained regularization term to different MR acquisition settings to validate the proposed method and compared the reconstruction with the commonly used $\ell_1$ regularization. We showed ~3 dB improvement in the peak signal to noise ratio, compared with conventional $\ell_1$ regularized reconstruction. We demonstrated the flexibility of the proposed method in choosing different undersampling patterns. We also evaluated the effect of parameter tuning for the deep learning regularization.

Supervised Contrastive Regression

Deep regression models typically learn in an end-to-end fashion and do not explicitly try to learn a regression-aware representation. Their representations tend to be fragmented and fail to capture the continuous nature of regression tasks. In this paper, we propose Supervised Contrastive Regression (SupCR), a framework that learns a regression-aware representation by contrasting samples against each other based on their target distance. SupCR is orthogonal to existing regression models, and can be used in combination with such models to improve performance. Extensive experiments using five real-world regression datasets that span computer vision, human-computer interaction, and healthcare show that using SupCR achieves the state-of-the-art performance and consistently improves prior regression baselines on all datasets, tasks, and input modalities. SupCR also improves robustness to data corruptions, resilience to reduced training data, performance on transfer learning, and generalization to unseen targets.

Targeted Supervised Contrastive Learning for Long-Tailed Recognition

Real-world data often exhibits long tail distributions with heavy class imbalance, where the majority classes can dominate the training process and alter the decision boundaries of the minority classes. Recently, researchers have investigated the potential of supervised contrastive learning for long-tailed recognition, and demonstrated that it provides a strong performance gain. In this paper, we show that while supervised contrastive learning can help improve performance, past baselines suffer from poor uniformity brought in by imbalanced data distribution. This poor uniformity manifests in samples from the minority class having poor separability in the feature space. To address this problem, we propose targeted supervised contrastive learning (TSC), which improves the uniformity of the feature distribution on the hypersphere. TSC first generates a set of targets uniformly distributed on a hypersphere. It then makes the features of different classes converge to these distinct and uniformly distributed targets during training. This forces all classes, including minority classes, to maintain a uniform distribution in the feature space, improves class boundaries, and provides better generalization even in the presence of long-tail data. Experiments on multiple datasets show that TSC achieves state-of-the-art performance on long-tailed recognition tasks.