CLEF: EEG Foundation Model for Learning Clinical Semantics

Clinical EEG interpretation requires reasoning over full EEG sessions and integrating signal patterns with clinical context. Existing EEG foundation models are largely designed for short-window decoding and do not incorporate clinical context. We introduce CLEF, a clinically grounded long-context EEG foundation model. CLEF represents EEG sessions as 3D multitaper spectrogram tokens, enabling tractable Transformer modeling at session scale, and aligns embeddings with neurologist reports and structured EHR data through contrastive objectives. We evaluate CLEF on a new 234-task benchmark spanning disease phenotypes, medication exposures, and EEG findings, with more than 260k EEG sessions from over 108k patients. CLEF outperforms prior EEG foundation models on 229 of 234 tasks, improving mean AUROC from 0.65 to 0.74. Reconstruction-only pretraining surpasses prior EEG foundation models, while report and EHR alignment yields further gains. Held-out concept and external-cohort experiments suggest that these representations transfer beyond observed alignment targets. These results support session-scale, clinically grounded representation learning as a promising foundation-model paradigm for clinical EEG.

WavesFM: Hierarchical Representation Learning for Longitudinal Wearable Sensor Waveforms

Wearable sensors enable the continuous acquisition of high-resolution physiological waveforms, such as photoplethysmography and accelerometry, under free-living conditions. However, inferring health-related phenotypes from these signals presents significant challenges due to high sampling frequencies, multimodal dependencies, and extreme sequence lengths (e.g., weeks of recordings), compounded by a scarcity of ground-truth labels. To address these challenges, existing self-supervised learning (SSL) methodologies typically follow two paradigms: (1) learning rich morphological representations from short waveform segments while collapsing longitudinal dynamics through simple aggregation, or (2) modeling behavioral patterns from coarse, hand-crafted features (e.g. heart rate, step counts) spanning longer horizons but foregoing subtle, predictive signatures in raw waveforms. To bridge this gap, we propose WavesFM, a foundation model utilizing a two-stage SSL framework for longitudinal physiological data. Specifically, we decompose the learning problem into two stages: first, a segment-level encoder is pretrained to extract local embeddings from short waveforms; subsequently, a temporal encoder is trained to model the sequence of these embeddings across a multi-day horizon. This hierarchical approach overcomes the computational complexity of high-resolution, long-sequence data, allowing the overall model to capture both local signal semantics and the complex circadian and inter-day variations governing physiological dynamics. Pretrained on over 6.8M hours (N=324k individuals) of recordings for the first stage and 5.3M hours (N=10k) for the second stage, WavesFM demonstrates superior performance across 58 diverse tasks spanning demographics, lifestyle, health conditions, and medications.

EgoLive: A Large-Scale Egocentric Dataset from Real-World Human Tasks

The advancement of robot learning is currently hindered by the scarcity of large-scale, high-quality datasets. While established data collection methods such as teleoperation and universal manipulation interfaces dominate current datasets, they suffer from inherent limitations in scalability and real-world deployability. Human egocentric video collection, by contrast, has emerged as a promising approach to enable scalable, natural and in-the-wild data collection. As such, we present EgoLive, a large-scale, high-quality egocentric dataset designed explicitly for robot manipulation learning. EgoLive establishes three distinctive technical advantages over existing egocentric datasets: first, it represents the largest open-source annotated egocentric dataset focused on real-world task-oriented human routines to date; second, it delivers leading data quality via a customized head-mounted capture device and comprehensive high-precision multi-modal annotations; third, all data is collected exclusively in unconstrained real-world scenarios and encompasses vertical field human working data, including home service, retail, and other practical work scenarios, providing superior diversity and ecological validity. With the introduction of EgoLive, we aim to provide the research community with a scalable, high-quality dataset that accelerates breakthroughs in generalizable robotic models and facilitates the real-world deployment of robot systems.

JoyAI-RA 0.1: A Foundation Model for Robotic Autonomy

Robotic autonomy in open-world environments is fundamentally limited by insufficient data diversity and poor cross-embodiment generalization. Existing robotic datasets are often limited in scale and task coverage, while relatively large differences across robot embodiments impede effective behavior knowledge transfer. To address these challenges, we propose JoyAI-RA, a vision-language-action (VLA) embodied foundation model tailored for generalizable robotic manipulation. JoyAI-RA presents a multi-source multi-level pretraining framework that integrates web data, large-scale egocentric human manipulation videos, simulation-generated trajectories, and real-robot data. Through training on heterogeneous multi-source data with explicit action-space unification, JoyAI-RA effectively bridges embodiment gaps, particularly between human manipulation and robotic control, thereby enhancing cross-embodiment behavior learning. JoyAI-RA outperforms state-of-the-art methods in both simulation and real-world benchmarks, especially on diverse tasks with generalization demands.

Multiscale Structure-Guided Latent Diffusion for Multimodal MRI Translation

Although diffusion models have achieved remarkable progress in multi-modal magnetic resonance imaging (MRI) translation tasks, existing methods still tend to suffer from anatomical inconsistencies or degraded texture details when handling arbitrary missing-modality scenarios. To address these issues, we propose a latent diffusion-based multi-modal MRI translation framework, termed MSG-LDM. By leveraging the available modalities, the proposed method infers complete structural information, which preserves reliable boundary details. Specifically, we introduce a style--structure disentanglement mechanism in the latent space, which explicitly separates modality-specific style features from shared structural representations, and jointly models low-frequency anatomical layouts and high-frequency boundary details in a multi-scale feature space. During the structure disentanglement stage, high-frequency structural information is explicitly incorporated to enhance feature representations, guiding the model to focus on fine-grained structural cues while learning modality-invariant low-frequency anatomical representations. Furthermore, to reduce interference from modality-specific styles and improve the stability of structure representations, we design a style consistency loss and a structure-aware loss. Extensive experiments on the BraTS2020 and WMH datasets demonstrate that the proposed method outperforms existing MRI synthesis approaches, particularly in reconstructing complete structures. The source code is publicly available at https://github.com/ziyi-start/MSG-LDM.

IDRL: An Individual-Aware Multimodal Depression-Related Representation Learning Framework for Depression Diagnosis

Depression is a severe mental disorder, and reliable identification plays a critical role in early intervention and treatment. Multimodal depression detection aims to improve diagnostic performance by jointly modeling complementary information from multiple modalities. Recently, numerous multimodal learning approaches have been proposed for depression analysis; however, these methods suffer from the following limitations: 1) inter-modal inconsistency and depression-unrelated interference, where depression-related cues may conflict across modalities while substantial irrelevant content obscures critical depressive signals, and 2) diverse individual depressive presentations, leading to individual differences in modality and cue importance that hinder reliable fusion. To address these issues, we propose Individual-aware Multimodal Depression-related Representation Learning Framework (IDRL) for robust depression diagnosis. Specifically, IDRL 1) disentangles multimodal representations into a modality-common depression space, a modality-specific depression space, and a depression-unrelated space to enhance modality alignment while suppressing irrelevant information, and 2) introduces an individual-aware modality-fusion module (IAF) that dynamically adjusts the weights of disentangled depression-related features based on their predictive significance, thereby achieving adaptive cross-modal fusion for different individuals. Extensive experiments demonstrate that IDRL achieves superior and robust performance for multimodal depression detection.

Visually-Guided Controllable Medical Image Generation via Fine-Grained Semantic Disentanglement

Medical image synthesis is crucial for alleviating data scarcity and privacy constraints. However, fine-tuning general text-to-image (T2I) models remains challenging, mainly due to the significant modality gap between complex visual details and abstract clinical text. In addition, semantic entanglement persists, where coarse-grained text embeddings blur the boundary between anatomical structures and imaging styles, thus weakening controllability during generation. To address this, we propose a Visually-Guided Text Disentanglement framework. We introduce a cross-modal latent alignment mechanism that leverages visual priors to explicitly disentangle unstructured text into independent semantic representations. Subsequently, a Hybrid Feature Fusion Module (HFFM) injects these features into a Diffusion Transformer (DiT) through separated channels, enabling fine-grained structural control. Experimental results in three datasets demonstrate that our method outperforms existing approaches in terms of generation quality and significantly improves performance on downstream classification tasks. The source code is available at https://github.com/hx111/VG-MedGen.

BrainSTR: Spatio-Temporal Contrastive Learning for Interpretable Dynamic Brain Network Modeling

Dynamic functional connectivity captures time-varying brain states for better neuropsychiatric diagnosis and spatio-temporal interpretability, i.e., identifying when discriminative disease signatures emerge and where they reside in the connectivity topology. Reliable interpretability faces major challenges: diagnostic signals are often subtle and sparsely distributed across both time and topology, while nuisance fluctuations and non-diagnostic connectivities are pervasive. To address these issues, we propose BrainSTR, a spatio-temporal contrastive learning framework for interpretable dynamic brain network modeling. BrainSTR learns state-consistent phase boundaries via a data-driven Adaptive Phase Partition module, identifies diagnostically critical phases with attention, and extracts disease-related connectivity within each phase using an Incremental Graph Structure Generator regularized by binarization, temporal smoothness, and sparsity. Then, we introduce a spatio-temporal supervised contrastive learning approach that leverages diagnosis-relevant spatio-temporal patterns to refine the similarity metric between samples and capture more discriminative spatio-temporal features, thereby constructing a well-structured semantic space for coherent and interpretable representations. Experiments on ASD, BD, and MDD validate the effectiveness of BrainSTR, and the discovered critical phases and subnetworks provide interpretable evidence consistent with prior neuroimaging findings. Our code: https://anonymous.4open.science/r/BrainSTR1.

Learning the Hierarchical Organization in Brain Network for Brain Disorder Diagnosis

Brain network analysis based on functional Magnetic Resonance Imaging (fMRI) is pivotal for diagnosing brain disorders. Existing approaches typically rely on predefined functional sub-networks to construct sub-network associations. However, we identified many cross-network interaction patterns with high Pearson correlations that this strict, prior-based organization fails to capture. To overcome this limitation, we propose the Brain Hierarchical Organization Learning (BrainHO) to learn inherently hierarchical brain network dependencies based on their intrinsic features rather than predefined sub-network labels. Specifically, we design a hierarchical attention mechanism that allows the model to aggregate nodes into a hierarchical organization, effectively capturing intricate connectivity patterns at the subgraph level. To ensure diverse, complementary, and stable organizations, we incorporate an orthogonality constraint loss, alongside a hierarchical consistency constraint strategy, to refine node-level features using high-level graph semantics. Extensive experiments on the publicly available ABIDE and REST-meta-MDD datasets demonstrate that BrainHO not only achieves state-of-the-art classification performance but also uncovers interpretable, clinically significant biomarkers by precisely localizing disease-related sub-networks.

Physiology as Language: Translating Respiration to Sleep EEG

This paper introduces a novel cross-physiology translation task: synthesizing sleep electroencephalography (EEG) from respiration signals. To address the significant complexity gap between the two modalities, we propose a waveform-conditional generative framework that preserves fine-grained respiratory dynamics while constraining the EEG target space through discrete tokenization. Trained on over 28,000 individuals, our model achieves a 7% Mean Absolute Error in EEG spectrogram reconstruction. Beyond reconstruction, the synthesized EEG supports downstream tasks with performance comparable to ground truth EEG on age estimation (MAE 5.0 vs. 5.1 years), sex detection (AUROC 0.81 vs. 0.82), and sleep staging (Accuracy 0.84 vs. 0.88), significantly outperforming baselines trained directly on breathing. Finally, we demonstrate that the framework generalizes to contactless sensing by synthesizing EEG from wireless radio-frequency reflections, highlighting the feasibility of remote, non-contact neurological assessment during sleep.