MUSE: Harnessing Precise and Diverse Semantics for Few-Shot Whole Slide Image Classification

In computational pathology, few-shot whole slide image classification is primarily driven by the extreme scarcity of expert-labeled slides. Recent vision-language methods incorporate textual semantics generated by large language models, but treat these descriptions as static class-level priors that are shared across all samples and lack sample-wise refinement. This limits both the diversity and precision of visual-semantic alignment, hindering generalization under limited supervision. To overcome this, we propose the stochastic MUlti-view Semantic Enhancement (MUSE), a framework that first refines semantic precision via sample-wise adaptation and then enhances semantic richness through retrieval-augmented multi-view generation. Specifically, MUSE introduces Sample-wise Fine-grained Semantic Enhancement (SFSE), which yields a fine-grained semantic prior for each sample through MoE-based adaptive visual-semantic interaction. Guided by this prior, Stochastic Multi-view Model Optimization (SMMO) constructs an LLM-generated knowledge base of diverse pathological descriptions per class, then retrieves and stochastically integrates multiple matched textual views during training. These dynamically selected texts serve as enriched semantic supervisions to stochastically optimize the vision-language model, promoting robustness and mitigating overfitting. Experiments on three benchmark WSI datasets show that MUSE consistently outperforms existing vision-language baselines in few-shot settings, demonstrating that effective few-shot pathology learning requires not only richer semantic sources but also their active and sample-aware semantic optimization. Our code is available at: https://github.com/JiahaoXu-god/CVPR2026_MUSE.

Category-Prompt Refined Feature Learning for Long-Tailed Multi-Label Image Classification

Real-world data consistently exhibits a long-tailed distribution, often spanning multiple categories. This complexity underscores the challenge of content comprehension, particularly in scenarios requiring Long-Tailed Multi-Label image Classification (LTMLC). In such contexts, imbalanced data distribution and multi-object recognition pose significant hurdles. To address this issue, we propose a novel and effective approach for LTMLC, termed Category-Prompt Refined Feature Learning (CPRFL), utilizing semantic correlations between different categories and decoupling category-specific visual representations for each category. Specifically, CPRFL initializes category-prompts from the pretrained CLIP's embeddings and decouples category-specific visual representations through interaction with visual features, thereby facilitating the establishment of semantic correlations between the head and tail classes. To mitigate the visual-semantic domain bias, we design a progressive Dual-Path Back-Propagation mechanism to refine the prompts by progressively incorporating context-related visual information into prompts. Simultaneously, the refinement process facilitates the progressive purification of the category-specific visual representations under the guidance of the refined prompts. Furthermore, taking into account the negative-positive sample imbalance, we adopt the Asymmetric Loss as our optimization objective to suppress negative samples across all classes and potentially enhance the head-to-tail recognition performance. We validate the effectiveness of our method on two LTMLC benchmarks and extensive experiments demonstrate the superiority of our work over baselines. The code is available at https://github.com/jiexuanyan/CPRFL.