Seed2GS: Camera-Free, Training-Free Object Extraction from 3D Gaussian Scenes via a Single Reference-View Grounding

Extracting a target object from a pre-built 3D Gaussian Splatting (3DGS) scene enables interactive 3D editing. Existing methods either train for tens of minutes per scene, sacrifice accuracy, or require original reconstruction cameras that pre-built assets may not include. We present Seed2GS, which achieves the highest reported LERF-MASK accuracy without original reconstruction cameras or scene-specific representation training. Its key insight is to separate target identity from 3D coverage. QD-SAM3 selects one reliable reference mask from several open-vocabulary candidates, fixing identity once. Seed lift and visibility-adaptive virtual orbits then expose the object from new viewpoints, while tracking propagates the seed without repeated detection. Because the scene remains frozen, these masks supervise only one temporary foreground logit per Gaussian. On LERF-MASK, Seed2GS reaches 92.1% mean intersection over union (mIoU) with a measured compute-only latency of 9.3 seconds, 3.7 points above the strongest scene-trained baseline and 7.6 points above the closest camera-free baseline. With one fixed test reference per scene, the complete pipeline retains 91.1% mIoU; replacing its predicted seed with a ground-truth mask improves mIoU by only 0.72 points. On 3D-OVS, Seed2GS reaches 95.7% mIoU.

MCPI: Integrating Multimodal Data for Enhanced Prediction of Compound Protein Interactions

The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both compounds and target proteins. While various prediction methods employ different feature combinations, both molecular-based and network-based models encounter the common obstacle of incomplete feature representations. Thus, a promising solution to this issue is to fully integrate all relevant CPI features. This study proposed a novel model named MCPI, which is designed to improve the prediction performance of CPI by integrating multiple sources of information, including the PPI network, CCI network, and structural features of CPI. The results of the study indicate that the MCPI model outperformed other existing methods for predicting CPI on public datasets. Furthermore, the study has practical implications for drug development, as the model was applied to search for potential inhibitors among FDA-approved drugs in response to the SARS-CoV-2 pandemic. The prediction results were then validated through the literature, suggesting that the MCPI model could be a useful tool for identifying potential drug candidates. Overall, this study has the potential to advance our understanding of CPI and guide drug development efforts.