OpenSRH: optimizing brain tumor surgery using intraoperative stimulated Raman histology

Accurate intraoperative diagnosis is essential for providing safe and effective care during brain tumor surgery. Our standard-of-care diagnostic methods are time, resource, and labor intensive, which restricts access to optimal surgical treatments. To address these limitations, we propose an alternative workflow that combines stimulated Raman histology (SRH), a rapid optical imaging method, with deep learning-based automated interpretation of SRH images for intraoperative brain tumor diagnosis and real-time surgical decision support. Here, we present OpenSRH, the first public dataset of clinical SRH images from 300+ brain tumors patients and 1300+ unique whole slide optical images. OpenSRH contains data from the most common brain tumors diagnoses, full pathologic annotations, whole slide tumor segmentations, raw and processed optical imaging data for end-to-end model development and validation. We provide a framework for patch-based whole slide SRH classification and inference using weak (i.e. patient-level) diagnostic labels. Finally, we benchmark two computer vision tasks: multiclass histologic brain tumor classification and patch-based contrastive representation learning. We hope OpenSRH will facilitate the clinical translation of rapid optical imaging and real-time ML-based surgical decision support in order to improve the access, safety, and efficacy of cancer surgery in the era of precision medicine. Dataset access, code, and benchmarks are available at opensrh.mlins.org.

Is Continual Learning Truly Learning Representations Continually?

Continual learning (CL) aims to learn from sequentially arriving tasks without forgetting previous tasks. Whereas CL algorithms have tried to achieve higher average test accuracy across all the tasks learned so far, learning continuously useful representations is critical for successful generalization and downstream transfer. To measure representational quality, we re-train only the output layers using a small balanced dataset for all the tasks, evaluating the average accuracy without any biased predictions toward the current task. We also test on several downstream tasks, measuring transfer learning accuracy of the learned representations. By testing our new formalism on ImageNet-100 and ImageNet-1000, we find that using more exemplar memory is the only option to make a meaningful difference in learned representations, and most of the regularization- or distillation-based CL algorithms that use the exemplar memory fail to learn continuously useful representations in class-incremental learning. Surprisingly, unsupervised (or self-supervised) CL with sufficient memory size can achieve comparable performance to the supervised counterparts. Considering non-trivial labeling costs, we claim that finding more efficient unsupervised CL algorithms that minimally use exemplary memory would be the next promising direction for CL research.

Few-shot Subgoal Planning with Language Models

Pre-trained large language models have shown successful progress in many language understanding benchmarks. This work explores the capability of these models to predict actionable plans in real-world environments. Given a text instruction, we show that language priors encoded in pre-trained language models allow us to infer fine-grained subgoal sequences. In contrast to recent methods which make strong assumptions about subgoal supervision, our experiments show that language models can infer detailed subgoal sequences from few training sequences without any fine-tuning. We further propose a simple strategy to re-rank language model predictions based on interaction and feedback from the environment. Combined with pre-trained navigation and visual reasoning components, our approach demonstrates competitive performance on subgoal prediction and task completion in the ALFRED benchmark compared to prior methods that assume more subgoal supervision.

LEPUS: Prompt-based Unsupervised Multi-hop Reranking for Open-domain QA

We study unsupervised multi-hop reranking for multi-hop QA (MQA) with open-domain questions. Since MQA requires piecing information from multiple documents, the main challenge thus resides in retrieving and reranking chains of passages that support the reasoning process. Our approach relies on LargE models with Prompt-Utilizing reranking Strategy (LEPUS): we construct an instruction-like prompt based on a candidate document path and compute a relevance score of the path as the probability of generating a given question, according to a pre-trained language model. Though unsupervised, LEPUS yields competitive reranking performance against state-of-the-art methods that are trained on thousands of examples. Adding a small number of samples (e.g., $2$), we demonstrate further performance gain using in-context learning. Finally, we show that when integrated with a reader module, LEPUS can obtain competitive multi-hop QA performance, e.g., outperforming fully-supervised QA systems. Code will be released at https://github.com/mukhal/LEPUS

Fast Inference and Transfer of Compositional Task Structures for Few-shot Task Generalization

We tackle real-world problems with complex structures beyond the pixel-based game or simulator. We formulate it as a few-shot reinforcement learning problem where a task is characterized by a subtask graph that defines a set of subtasks and their dependencies that are unknown to the agent. Different from the previous meta-rl methods trying to directly infer the unstructured task embedding, our multi-task subtask graph inferencer (MTSGI) first infers the common high-level task structure in terms of the subtask graph from the training tasks, and use it as a prior to improve the task inference in testing. Our experiment results on 2D grid-world and complex web navigation domains show that the proposed method can learn and leverage the common underlying structure of the tasks for faster adaptation to the unseen tasks than various existing algorithms such as meta reinforcement learning, hierarchical reinforcement learning, and other heuristic agents.

RiCS: A 2D Self-Occlusion Map for Harmonizing Volumetric Objects

There have been remarkable successes in computer vision with deep learning. While such breakthroughs show robust performance, there have still been many challenges in learning in-depth knowledge, like occlusion or predicting physical interactions. Although some recent works show the potential of 3D data in serving such context, it is unclear how we efficiently provide 3D input to the 2D models due to the misalignment in dimensionality between 2D and 3D. To leverage the successes of 2D models in predicting self-occlusions, we design Ray-marching in Camera Space (RiCS), a new method to represent the self-occlusions of foreground objects in 3D into a 2D self-occlusion map. We test the effectiveness of our representation on the human image harmonization task by predicting shading that is coherent with a given background image. Our experiments demonstrate that our representation map not only allows us to enhance the image quality but also to model temporally coherent complex shadow effects compared with the simulation-to-real and harmonization methods, both quantitatively and qualitatively. We further show that we can significantly improve the performance of human parts segmentation networks trained on existing synthetic datasets by enhancing the harmonization quality with our method.

Simple and Effective Synthesis of Indoor 3D Scenes

We study the problem of synthesizing immersive 3D indoor scenes from one or more images. Our aim is to generate high-resolution images and videos from novel viewpoints, including viewpoints that extrapolate far beyond the input images while maintaining 3D consistency. Existing approaches are highly complex, with many separately trained stages and components. We propose a simple alternative: an image-to-image GAN that maps directly from reprojections of incomplete point clouds to full high-resolution RGB-D images. On the Matterport3D and RealEstate10K datasets, our approach significantly outperforms prior work when evaluated by humans, as well as on FID scores. Further, we show that our model is useful for generative data augmentation. A vision-and-language navigation (VLN) agent trained with trajectories spatially-perturbed by our model improves success rate by up to 1.5% over a state of the art baseline on the R2R benchmark. Our code will be made available to facilitate generative data augmentation and applications to downstream robotics and embodied AI tasks.

Learning Parameterized Task Structure for Generalization to Unseen Entities

Real world tasks are hierarchical and compositional. Tasks can be composed of multiple subtasks (or sub-goals) that are dependent on each other. These subtasks are defined in terms of entities (e.g., "apple", "pear") that can be recombined to form new subtasks (e.g., "pickup apple", and "pickup pear"). To solve these tasks efficiently, an agent must infer subtask dependencies (e.g. an agent must execute "pickup apple" before "place apple in pot"), and generalize the inferred dependencies to new subtasks (e.g. "place apple in pot" is similar to "place apple in pan"). Moreover, an agent may also need to solve unseen tasks, which can involve unseen entities. To this end, we formulate parameterized subtask graph inference (PSGI), a method for modeling subtask dependencies using first-order logic with subtask entities. To facilitate this, we learn entity attributes in a zero-shot manner, which are used as quantifiers (e.g. "is_pickable(X)") for the parameterized subtask graph. We show this approach accurately learns the latent structure on hierarchical and compositional tasks more efficiently than prior work, and show PSGI can generalize by modelling structure on subtasks unseen during adaptation.

SURF: Semi-supervised Reward Learning with Data Augmentation for Feedback-efficient Preference-based Reinforcement Learning

Preference-based reinforcement learning (RL) has shown potential for teaching agents to perform the target tasks without a costly, pre-defined reward function by learning the reward with a supervisor's preference between the two agent behaviors. However, preference-based learning often requires a large amount of human feedback, making it difficult to apply this approach to various applications. This data-efficiency problem, on the other hand, has been typically addressed by using unlabeled samples or data augmentation techniques in the context of supervised learning. Motivated by the recent success of these approaches, we present SURF, a semi-supervised reward learning framework that utilizes a large amount of unlabeled samples with data augmentation. In order to leverage unlabeled samples for reward learning, we infer pseudo-labels of the unlabeled samples based on the confidence of the preference predictor. To further improve the label-efficiency of reward learning, we introduce a new data augmentation that temporally crops consecutive subsequences from the original behaviors. Our experiments demonstrate that our approach significantly improves the feedback-efficiency of the state-of-the-art preference-based method on a variety of locomotion and robotic manipulation tasks.

Rich CNN-Transformer Feature Aggregation Networks for Super-Resolution

Recent vision transformers along with self-attention have achieved promising results on various computer vision tasks. In particular, a pure transformer-based image restoration architecture surpasses the existing CNN-based methods using multi-task pre-training with a large number of trainable parameters. In this paper, we introduce an effective hybrid architecture for super-resolution (SR) tasks, which leverages local features from CNNs and long-range dependencies captured by transformers to further improve the SR results. Specifically, our architecture comprises of transformer and convolution branches, and we substantially elevate the performance by mutually fusing two branches to complement each representation. Furthermore, we propose a cross-scale token attention module, which allows the transformer to efficiently exploit the informative relationships among tokens across different scales. Our proposed method achieves state-of-the-art SR results on numerous benchmark datasets.