FACT-E: Causality-Inspired Evaluation for Trustworthy Chain-of-Thought Reasoning

Chain-of-Thought (CoT) prompting has improved LLM reasoning, but models often generate explanations that appear coherent while containing unfaithful intermediate steps. Existing self-evaluation approaches are prone to inherent biases: the model may confidently endorse coherence even when the step-to-step implication is not valid, leading to unreliable faithfulness evaluation. We propose FACT-E, a causality-inspired framework for evaluating CoT quality. FACT-E uses controlled perturbations as an instrumental signal to separate genuine step-to-step dependence from bias-driven artifacts, producing more reliable faithfulness estimates (\textit{intra-chain faithfulness}). To select trustworthy trajectories, FACT-E jointly considers \textit{intra-chain faithfulness} and \textit{CoT-to-answer consistency}, ensuring that selected chains are both faithful internally and supportive of the correct final answer. Experiments on GSM8K, MATH, and CommonsenseQA show that FACT-E improves reasoning-trajectory selection and yields stronger in-context learning exemplars. FACT-E also reliably detects flawed reasoning under noisy conditions, providing a robust metric for trustworthy LLM reasoning.

Automated Prostate Cancer Diagnosis Based on Gleason Grading Using Convolutional Neural Network

The Gleason grading system using histological images is the most powerful diagnostic and prognostic predictor of prostate cancer. The current standard inspection is evaluating Gleason H&E-stained histopathology images by pathologists. However, it is complicated, time-consuming, and subject to observers. Deep learning (DL) based-methods that automatically learn image features and achieve higher generalization ability have attracted significant attention. However, challenges remain especially using DL to train the whole slide image (WSI), a predominant clinical source in the current diagnostic setting, containing billions of pixels, morphological heterogeneity, and artifacts. Hence, we proposed a convolutional neural network (CNN)-based automatic classification method for accurate grading of PCa using whole slide histopathology images. In this paper, a data augmentation method named Patch-Based Image Reconstruction (PBIR) was proposed to reduce the high resolution and increase the diversity of WSIs. In addition, a distribution correction (DC) module was developed to enhance the adaption of pretrained model to the target dataset by adjusting the data distribution. Besides, a Quadratic Weighted Mean Square Error (QWMSE) function was presented to reduce the misdiagnosis caused by equal Euclidean distances. Our experiments indicated the combination of PBIR, DC, and QWMSE function was necessary for achieving superior expert-level performance, leading to the best results (0.8885 quadratic-weighted kappa coefficient).

Boosted EfficientNet: Detection of Lymph Node Metastases in Breast Cancer Using Convolutional Neural Network

In recent years, advances in the development of whole-slide images have laid a foundation for the utilization of digital images in pathology. With the assistance of computer images analysis that automatically identifies tissue or cell types, they have greatly improved the histopathologic interpretation and diagnosis accuracy. In this paper, the Convolutional Neutral Network (CNN) has been adapted to predict and classify lymph node metastasis in breast cancer. Unlike traditional image cropping methods that are only suitable for large resolution images, we propose a novel data augmentation method named Random Center Cropping (RCC) to facilitate small resolution images. RCC enriches the datasets while retaining the image resolution and the center area of images. In addition, we reduce the downsampling scale of the network to further facilitate small resolution images better. Moreover, Attention and Feature Fusion (FF) mechanisms are employed to improve the semantic information of images. Experiments demonstrate that our methods boost performances of basic CNN architectures. And the best-performed method achieves an accuracy of 97.96% and an AUC of 99.68% on RPCam datasets, respectively.