Federated and distributed learning applications for electronic health records and structured medical data: A scoping review

Federated learning (FL) has gained popularity in clinical research in recent years to facilitate privacy-preserving collaboration. Structured data, one of the most prevalent forms of clinical data, has experienced significant growth in volume concurrently, notably with the widespread adoption of electronic health records in clinical practice. This review examines FL applications on structured medical data, identifies contemporary limitations and discusses potential innovations. We searched five databases, SCOPUS, MEDLINE, Web of Science, Embase, and CINAHL, to identify articles that applied FL to structured medical data and reported results following the PRISMA guidelines. Each selected publication was evaluated from three primary perspectives, including data quality, modeling strategies, and FL frameworks. Out of the 1160 papers screened, 34 met the inclusion criteria, with each article consisting of one or more studies that used FL to handle structured clinical/medical data. Of these, 24 utilized data acquired from electronic health records, with clinical predictions and association studies being the most common clinical research tasks that FL was applied to. Only one article exclusively explored the vertical FL setting, while the remaining 33 explored the horizontal FL setting, with only 14 discussing comparisons between single-site (local) and FL (global) analysis. The existing FL applications on structured medical data lack sufficient evaluations of clinically meaningful benefits, particularly when compared to single-site analyses. Therefore, it is crucial for future FL applications to prioritize clinical motivations and develop designs and methodologies that can effectively support and aid clinical practice and research.

Analysing Fairness of Privacy-Utility Mobility Models

Preserving the individuals' privacy in sharing spatial-temporal datasets is critical to prevent re-identification attacks based on unique trajectories. Existing privacy techniques tend to propose ideal privacy-utility tradeoffs, however, largely ignore the fairness implications of mobility models and whether such techniques perform equally for different groups of users. The quantification between fairness and privacy-aware models is still unclear and there barely exists any defined sets of metrics for measuring fairness in the spatial-temporal context. In this work, we define a set of fairness metrics designed explicitly for human mobility, based on structural similarity and entropy of the trajectories. Under these definitions, we examine the fairness of two state-of-the-art privacy-preserving models that rely on GAN and representation learning to reduce the re-identification rate of users for data sharing. Our results show that while both models guarantee group fairness in terms of demographic parity, they violate individual fairness criteria, indicating that users with highly similar trajectories receive disparate privacy gain. We conclude that the tension between the re-identification task and individual fairness needs to be considered for future spatial-temporal data analysis and modelling to achieve a privacy-preserving fairness-aware setting.

Information Theory Inspired Pattern Analysis for Time-series Data

Current methods for pattern analysis in time series mainly rely on statistical features or probabilistic learning and inference methods to identify patterns and trends in the data. Such methods do not generalize well when applied to multivariate, multi-source, state-varying, and noisy time-series data. To address these issues, we propose a highly generalizable method that uses information theory-based features to identify and learn from patterns in multivariate time-series data. To demonstrate the proposed approach, we analyze pattern changes in human activity data. For applications with stochastic state transitions, features are developed based on Shannon's entropy of Markov chains, entropy rates of Markov chains, entropy production of Markov chains, and von Neumann entropy of Markov chains. For applications where state modeling is not applicable, we utilize five entropy variants, including approximate entropy, increment entropy, dispersion entropy, phase entropy, and slope entropy. The results show the proposed information theory-based features improve the recall rate, F1 score, and accuracy on average by up to 23.01\% compared with the baseline models and a simpler model structure, with an average reduction of 18.75 times in the number of model parameters.

Using Entropy Measures for Monitoring the Evolution of Activity Patterns

In this work, we apply information theory inspired methods to quantify changes in daily activity patterns. We use in-home movement monitoring data and show how they can help indicate the occurrence of healthcare-related events. Three different types of entropy measures namely Shannon's entropy, entropy rates for Markov chains, and entropy production rate have been utilised. The measures are evaluated on a large-scale in-home monitoring dataset that has been collected within our dementia care clinical study. The study uses Internet of Things (IoT) enabled solutions for continuous monitoring of in-home activity, sleep, and physiology to develop care and early intervention solutions to support people living with dementia (PLWD) in their own homes. Our main goal is to show the applicability of the entropy measures to time-series activity data analysis and to use the extracted measures as new engineered features that can be fed into inference and analysis models. The results of our experiments show that in most cases the combination of these measures can indicate the occurrence of healthcare-related events. We also find that different participants with the same events may have different measures based on one entropy measure. So using a combination of these measures in an inference model will be more effective than any of the single measures.

SoK: Machine Learning with Confidential Computing

Privacy and security challenges in Machine Learning (ML) have become a critical topic to address, along with ML's pervasive development and the recent demonstration of large attack surfaces. As a mature system-oriented approach, confidential computing has been increasingly utilized in both academia and industry to improve privacy and security in various ML scenarios. In this paper, we systematize the findings on confidential computing-assisted ML security and privacy techniques for providing i) confidentiality guarantees and ii) integrity assurances. We further identify key challenges and provide dedicated analyses of the limitations in existing Trusted Execution Environment (TEE) systems for ML use cases. We discuss prospective works, including grounded privacy definitions, partitioned ML executions, dedicated TEE designs for ML, TEE-aware ML, and ML full pipeline guarantee. These potential solutions can help achieve a much strong TEE-enabled ML for privacy guarantees without introducing computation and system costs.

Privacy-Aware Adversarial Network in Human Mobility Prediction

As mobile devices and location-based services are increasingly developed in different smart city scenarios and applications, many unexpected privacy leakages have arisen due to geolocated data collection and sharing. User re-identification and other sensitive inferences are major privacy threats when geolocated data are shared with cloud-assisted applications. Significantly, four spatio-temporal points are enough to uniquely identify 95\% of the individuals, which exacerbates personal information leakages. To tackle malicious purposes such as user re-identification, we propose an LSTM-based adversarial mechanism with representation learning to attain a privacy-preserving feature representation of the original geolocated data (i.e., mobility data) for a sharing purpose. These representations aim to maximally reduce the chance of user re-identification and full data reconstruction with a minimal utility budget (i.e., loss). We train the mechanism by quantifying privacy-utility trade-off of mobility datasets in terms of trajectory reconstruction risk, user re-identification risk, and mobility predictability. We report an exploratory analysis that enables the user to assess this trade-off with a specific loss function and its weight parameters. The extensive comparison results on four representative mobility datasets demonstrate the superiority of our proposed architecture in mobility privacy protection and the efficiency of the proposed privacy-preserving features extractor. We show that the privacy of mobility traces attains decent protection at the cost of marginal mobility utility. Our results also show that by exploring the Pareto optimal setting, we can simultaneously increase both privacy (45%) and utility (32%).

FIB: A Method for Evaluation of Feature Impact Balance in Multi-Dimensional Data

Errors might not have the same consequences depending on the task at hand. Nevertheless, there is limited research investigating the impact of imbalance in the contribution of different features in an error vector. Therefore, we propose the Feature Impact Balance (FIB) score. It measures whether there is a balanced impact of features in the discrepancies between two vectors. We designed the FIB score to lie in [0, 1]. Scores close to 0 indicate that a small number of features contribute to most of the error, and scores close to 1 indicate that most features contribute to the error equally. We experimentally study the FIB on different datasets, using AutoEncoders and Variational AutoEncoders. We show how the feature impact balance varies during training and showcase its usability to support model selection for single output and multi-output tasks.

Distributed data analytics

Machine Learning (ML) techniques have begun to dominate data analytics applications and services. Recommendation systems are a key component of online service providers. The financial industry has adopted ML to harness large volumes of data in areas such as fraud detection, risk-management, and compliance. Deep Learning is the technology behind voice-based personal assistants, etc. Deployment of ML technologies onto cloud computing infrastructures has benefited numerous aspects of our daily life. The advertising and associated online industries in particular have fuelled a rapid rise the in deployment of personal data collection and analytics tools. Traditionally, behavioural analytics relies on collecting vast amounts of data in centralised cloud infrastructure before using it to train machine learning models that allow user behaviour and preferences to be inferred. A contrasting approach, distributed data analytics, where code and models for training and inference are distributed to the places where data is collected, has been boosted by two recent, ongoing developments: increased processing power and memory capacity available in user devices at the edge of the network, such as smartphones and home assistants; and increased sensitivity to the highly intrusive nature of many of these devices and services and the attendant demands for improved privacy. Indeed, the potential for increased privacy is not the only benefit of distributing data analytics to the edges of the network: reducing the movement of large volumes of data can also improve energy efficiency, helping to ameliorate the ever increasing carbon footprint of our digital infrastructure, enabling much lower latency for service interactions than is possible when services are cloud-hosted. These approaches often introduce challenges in privacy, utility, and efficiency trade-offs, while having to ensure fruitful user engagement.

Towards Battery-Free Machine Learning and Inference in Underwater Environments

This paper is motivated by a simple question: Can we design and build battery-free devices capable of machine learning and inference in underwater environments? An affirmative answer to this question would have significant implications for a new generation of underwater sensing and monitoring applications for environmental monitoring, scientific exploration, and climate/weather prediction. To answer this question, we explore the feasibility of bridging advances from the past decade in two fields: battery-free networking and low-power machine learning. Our exploration demonstrates that it is indeed possible to enable battery-free inference in underwater environments. We designed a device that can harvest energy from underwater sound, power up an ultra-low-power microcontroller and on-board sensor, perform local inference on sensed measurements using a lightweight Deep Neural Network, and communicate the inference result via backscatter to a receiver. We tested our prototype in an emulated marine bioacoustics application, demonstrating the potential to recognize underwater animal sounds without batteries. Through this exploration, we highlight the challenges and opportunities for making underwater battery-free inference and machine learning ubiquitous.

Privacy-Aware Human Mobility Prediction via Adversarial Networks

As various mobile devices and location-based services are increasingly developed in different smart city scenarios and applications, many unexpected privacy leakages have arisen due to geolocated data collection and sharing. While these geolocated data could provide a rich understanding of human mobility patterns and address various societal research questions, privacy concerns for users' sensitive information have limited their utilization. In this paper, we design and implement a novel LSTM-based adversarial mechanism with representation learning to attain a privacy-preserving feature representation of the original geolocated data (mobility data) for a sharing purpose. We quantify the utility-privacy trade-off of mobility datasets in terms of trajectory reconstruction risk, user re-identification risk, and mobility predictability. Our proposed architecture reports a Pareto Frontier analysis that enables the user to assess this trade-off as a function of Lagrangian loss weight parameters. The extensive comparison results on four representative mobility datasets demonstrate the superiority of our proposed architecture and the efficiency of the proposed privacy-preserving features extractor. Our results show that by exploring Pareto optimal setting, we can simultaneously increase both privacy (45%) and utility (32%).