Accurate Congenital Heart Disease ModelGeneration for 3D Printing

3D printing has been widely adopted for clinical decision making and interventional planning of Congenital heart disease (CHD), while whole heart and great vessel segmentation is the most significant but time-consuming step in the model generation for 3D printing. While various automatic whole heart and great vessel segmentation frameworks have been developed in the literature, they are ineffective when applied to medical images in CHD, which have significant variations in heart structure and great vessel connections. To address the challenge, we leverage the power of deep learning in processing regular structures and that of graph algorithms in dealing with large variations and propose a framework that combines both for whole heart and great vessel segmentation in CHD. Particularly, we first use deep learning to segment the four chambers and myocardium followed by bloodpool, where variations are usually small. We then extract the connection information and apply graph matching to determine the categories of all the vessels. Experimental results using 683D CT images covering 14 types of CHD show that our method can increase Dice score by 11.9% on average compared with the state-of-the-art whole heart and great vessel segmentation method in normal anatomy. The segmentation results are also printed out using 3D printers for validation.

Machine Vision Guided 3D Medical Image Compression for Efficient Transmission and Accurate Segmentation in the Clouds

Cloud based medical image analysis has become popular recently due to the high computation complexities of various deep neural network (DNN) based frameworks and the increasingly large volume of medical images that need to be processed. It has been demonstrated that for medical images the transmission from local to clouds is much more expensive than the computation in the clouds itself. Towards this, 3D image compression techniques have been widely applied to reduce the data traffic. However, most of the existing image compression techniques are developed around human vision, i.e., they are designed to minimize distortions that can be perceived by human eyes. In this paper we will use deep learning based medical image segmentation as a vehicle and demonstrate that interestingly, machine and human view the compression quality differently. Medical images compressed with good quality w.r.t. human vision may result in inferior segmentation accuracy. We then design a machine vision oriented 3D image compression framework tailored for segmentation using DNNs. Our method automatically extracts and retains image features that are most important to the segmentation. Comprehensive experiments on widely adopted segmentation frameworks with HVSMR 2016 challenge dataset show that our method can achieve significantly higher segmentation accuracy at the same compression rate, or much better compression rate under the same segmentation accuracy, when compared with the existing JPEG 2000 method. To the best of the authors' knowledge, this is the first machine vision guided medical image compression framework for segmentation in the clouds.