MetaMP: Seamless Metadata Enrichment and AI Application Framework for Enhanced Membrane Protein Visualization and Analysis

Structural biology has made significant progress in determining membrane proteins, leading to a remarkable increase in the number of available structures in dedicated databases. The inherent complexity of membrane protein structures, coupled with challenges such as missing data, inconsistencies, and computational barriers from disparate sources, underscores the need for improved database integration. To address this gap, we present MetaMP, a framework that unifies membrane-protein databases within a web application and uses machine learning for classification. MetaMP improves data quality by enriching metadata, offering a user-friendly interface, and providing eight interactive views for streamlined exploration. MetaMP was effective across tasks of varying difficulty, demonstrating advantages across different levels without compromising speed or accuracy, according to user evaluations. Moreover, MetaMP supports essential functions such as structure classification and outlier detection. We present three practical applications of Artificial Intelligence (AI) in membrane protein research: predicting transmembrane segments, reconciling legacy databases, and classifying structures with explainable AI support. In a validation focused on statistics, MetaMP resolved 77% of data discrepancies and accurately predicted the class of newly identified membrane proteins 98% of the time and overtook expert curation. Altogether, MetaMP is a much-needed resource that harmonizes current knowledge and empowers AI-driven exploration of membrane-protein architecture.

PHAX: A Structured Argumentation Framework for User-Centered Explainable AI in Public Health and Biomedical Sciences

Ensuring transparency and trust in AI-driven public health and biomedical sciences systems requires more than accurate predictions-it demands explanations that are clear, contextual, and socially accountable. While explainable AI (XAI) has advanced in areas like feature attribution and model interpretability, most methods still lack the structure and adaptability needed for diverse health stakeholders, including clinicians, policymakers, and the general public. We introduce PHAX-a Public Health Argumentation and eXplainability framework-that leverages structured argumentation to generate human-centered explanations for AI outputs. PHAX is a multi-layer architecture combining defeasible reasoning, adaptive natural language techniques, and user modeling to produce context-aware, audience-specific justifications. More specifically, we show how argumentation enhances explainability by supporting AI-driven decision-making, justifying recommendations, and enabling interactive dialogues across user types. We demonstrate the applicability of PHAX through use cases such as medical term simplification, patient-clinician communication, and policy justification. In particular, we show how simplification decisions can be modeled as argument chains and personalized based on user expertise-enhancing both interpretability and trust. By aligning formal reasoning methods with communicative demands, PHAX contributes to a broader vision of transparent, human-centered AI in public health.

AI Readiness in Healthcare through Storytelling XAI

Artificial Intelligence is rapidly advancing and radically impacting everyday life, driven by the increasing availability of computing power. Despite this trend, the adoption of AI in real-world healthcare is still limited. One of the main reasons is the trustworthiness of AI models and the potential hesitation of domain experts with model predictions. Explainable Artificial Intelligence (XAI) techniques aim to address these issues. However, explainability can mean different things to people with different backgrounds, expertise, and goals. To address the target audience with diverse needs, we develop storytelling XAI. In this research, we have developed an approach that combines multi-task distillation with interpretability techniques to enable audience-centric explainability. Using multi-task distillation allows the model to exploit the relationships between tasks, potentially improving interpretability as each task supports the other leading to an enhanced interpretability from the perspective of a domain expert. The distillation process allows us to extend this research to large deep models that are highly complex. We focus on both model-agnostic and model-specific methods of interpretability, supported by textual justification of the results in healthcare through our use case. Our methods increase the trust of both the domain experts and the machine learning experts to enable a responsible AI.

Cooperative Learning with Gaussian Processes for Euler-Lagrange Systems Tracking Control under Switching Topologies

This work presents an innovative learning-based approach to tackle the tracking control problem of Euler-Lagrange multi-agent systems with partially unknown dynamics operating under switching communication topologies. The approach leverages a correlation-aware cooperative algorithm framework built upon Gaussian process regression, which adeptly captures inter-agent correlations for uncertainty predictions. A standout feature is its exceptional efficiency in deriving the aggregation weights achieved by circumventing the computationally intensive posterior variance calculations. Through Lyapunov stability analysis, the distributed control law ensures bounded tracking errors with high probability. Simulation experiments validate the protocol's efficacy in effectively managing complex scenarios, establishing it as a promising solution for robust tracking control in multi-agent systems characterized by uncertain dynamics and dynamic communication structures.

Decentralized Event-Triggered Online Learning for Safe Consensus of Multi-Agent Systems with Gaussian Process Regression

Consensus control in multi-agent systems has received significant attention and practical implementation across various domains. However, managing consensus control under unknown dynamics remains a significant challenge for control design due to system uncertainties and environmental disturbances. This paper presents a novel learning-based distributed control law, augmented by an auxiliary dynamics. Gaussian processes are harnessed to compensate for the unknown components of the multi-agent system. For continuous enhancement in predictive performance of Gaussian process model, a data-efficient online learning strategy with a decentralized event-triggered mechanism is proposed. Furthermore, the control performance of the proposed approach is ensured via the Lyapunov theory, based on a probabilistic guarantee for prediction error bounds. To demonstrate the efficacy of the proposed learning-based controller, a comparative analysis is conducted, contrasting it with both conventional distributed control laws and offline learning methodologies.

Whom to Trust? Elective Learning for Distributed Gaussian Process Regression

This paper introduces an innovative approach to enhance distributed cooperative learning using Gaussian process (GP) regression in multi-agent systems (MASs). The key contribution of this work is the development of an elective learning algorithm, namely prior-aware elective distributed GP (Pri-GP), which empowers agents with the capability to selectively request predictions from neighboring agents based on their trustworthiness. The proposed Pri-GP effectively improves individual prediction accuracy, especially in cases where the prior knowledge of an agent is incorrect. Moreover, it eliminates the need for computationally intensive variance calculations for determining aggregation weights in distributed GP. Furthermore, we establish a prediction error bound within the Pri-GP framework, ensuring the reliability of predictions, which is regarded as a crucial property in safety-critical MAS applications.

Learning-based Control for PMSM Using Distributed Gaussian Processes with Optimal Aggregation Strategy

The growing demand for accurate control in varying and unknown environments has sparked a corresponding increase in the requirements for power supply components, including permanent magnet synchronous motors (PMSMs). To infer the unknown part of the system, machine learning techniques are widely employed, especially Gaussian process regression (GPR) due to its flexibility of continuous system modeling and its guaranteed performance. For practical implementation, distributed GPR is adopted to alleviate the high computational complexity. However, the study of distributed GPR from a control perspective remains an open problem. In this paper, a control-aware optimal aggregation strategy of distributed GPR for PMSMs is proposed based on the Lyapunov stability theory. This strategy exclusively leverages the posterior mean, thereby obviating the need for computationally intensive calculations associated with posterior variance in alternative approaches. Moreover, the straightforward calculation process of our proposed strategy lends itself to seamless implementation in high-frequency PMSM control. The effectiveness of the proposed strategy is demonstrated in the simulations.