Interpretable pap smear cell representation for cervical cancer screening

Screening is critical for prevention and early detection of cervical cancer but it is time-consuming and laborious. Supervised deep convolutional neural networks have been developed to automate pap smear screening and the results are promising. However, the interest in using only normal samples to train deep neural networks has increased owing to class imbalance problems and high-labeling costs that are both prevalent in healthcare. In this study, we introduce a method to learn explainable deep cervical cell representations for pap smear cytology images based on one class classification using variational autoencoders. Findings demonstrate that a score can be calculated for cell abnormality without training models with abnormal samples and localize abnormality to interpret our results with a novel metric based on absolute difference in cross entropy in agglomerative clustering. The best model that discriminates squamous cell carcinoma (SCC) from normals gives 0.908 +- 0.003 area under operating characteristic curve (AUC) and one that discriminates high-grade epithelial lesion (HSIL) 0.920 +- 0.002 AUC. Compared to other clustering methods, our method enhances the V-measure and yields higher homogeneity scores, which more effectively isolate different abnormality regions, aiding in the interpretation of our results. Evaluation using in-house and additional open dataset show that our model can discriminate abnormality without the need of additional training of deep models.

Ensemble-Based Deep Reinforcement Learning for Chatbots

Trainable chatbots that exhibit fluent and human-like conversations remain a big challenge in artificial intelligence. Deep Reinforcement Learning (DRL) is promising for addressing this challenge, but its successful application remains an open question. This article describes a novel ensemble-based approach applied to value-based DRL chatbots, which use finite action sets as a form of meaning representation. In our approach, while dialogue actions are derived from sentence clustering, the training datasets in our ensemble are derived from dialogue clustering. The latter aim to induce specialised agents that learn to interact in a particular style. In order to facilitate neural chatbot training using our proposed approach, we assume dialogue data in raw text only -- without any manually-labelled data. Experimental results using chitchat data reveal that (1) near human-like dialogue policies can be induced, (2) generalisation to unseen data is a difficult problem, and (3) training an ensemble of chatbot agents is essential for improved performance over using a single agent. In addition to evaluations using held-out data, our results are further supported by a human evaluation that rated dialogues in terms of fluency, engagingness and consistency -- which revealed that our proposed dialogue rewards strongly correlate with human judgements.

Deep Reinforcement Learning for Chatbots Using Clustered Actions and Human-Likeness Rewards

Training chatbots using the reinforcement learning paradigm is challenging due to high-dimensional states, infinite action spaces and the difficulty in specifying the reward function. We address such problems using clustered actions instead of infinite actions, and a simple but promising reward function based on human-likeness scores derived from human-human dialogue data. We train Deep Reinforcement Learning (DRL) agents using chitchat data in raw text---without any manual annotations. Experimental results using different splits of training data report the following. First, that our agents learn reasonable policies in the environments they get familiarised with, but their performance drops substantially when they are exposed to a test set of unseen dialogues. Second, that the choice of sentence embedding size between 100 and 300 dimensions is not significantly different on test data. Third, that our proposed human-likeness rewards are reasonable for training chatbots as long as they use lengthy dialogue histories of >=10 sentences.

A Study on Dialogue Reward Prediction for Open-Ended Conversational Agents

The amount of dialogue history to include in a conversational agent is often underestimated and/or set in an empirical and thus possibly naive way. This suggests that principled investigations into optimal context windows are urgently needed given that the amount of dialogue history and corresponding representations can play an important role in the overall performance of a conversational system. This paper studies the amount of history required by conversational agents for reliably predicting dialogue rewards. The task of dialogue reward prediction is chosen for investigating the effects of varying amounts of dialogue history and their impact on system performance. Experimental results using a dataset of 18K human-human dialogues report that lengthy dialogue histories of at least 10 sentences are preferred (25 sentences being the best in our experiments) over short ones, and that lengthy histories are useful for training dialogue reward predictors with strong positive correlations between target dialogue rewards and predicted ones.