Large pre-trained language models (PLMs) have shown remarkable performance across various natural language understanding (NLU) tasks, particularly in low-resource settings. Nevertheless, their potential in Automatic Speech Recognition (ASR) remains largely unexplored. This study investigates the potential usage of PLMs for language modelling in ASR. We compare the application of large-scale text sampling and probability conversion for approximating GPT-2 into an n-gram model. Furthermore, we introduce a vocabulary-restricted decoding method for random sampling, and evaluate the effects of domain difficulty and data size on the usability of generated text. Our findings across eight domain-specific corpora support the use of sampling-based approximation and show that interpolating with a large sampled corpus improves test perplexity over a baseline trigram by 15%. Our vocabulary-restricted decoding method pushes this improvement further by 5% in domain-specific settings.
Deep learning has made great strides in medical imaging, enabled by hardware advances in GPUs. One major constraint for the development of new models has been the saturation of GPU memory resources during training. This is especially true in computational pathology, where images regularly contain more than 1 billion pixels. These pathological images are traditionally divided into small patches to enable deep learning due to hardware limitations. In this work, we explore whether the shared GPU/CPU memory architecture on the M1 Ultra systems-on-a-chip (SoCs) recently released by Apple, Inc. may provide a solution. These affordable systems (less than \$5000) provide access to 128 GB of unified memory (Mac Studio with M1 Ultra SoC). As a proof of concept for gigapixel deep learning, we identified tissue from background on gigapixel areas from whole slide images (WSIs). The model was a modified U-Net (4492 parameters) leveraging large kernels and high stride. The M1 Ultra SoC was able to train the model directly on gigapixel images (16000$\times$64000 pixels, 1.024 billion pixels) with a batch size of 1 using over 100 GB of unified memory for the process at an average speed of 1 minute and 21 seconds per batch with Tensorflow 2/Keras. As expected, the model converged with a high Dice score of 0.989 $\pm$ 0.005. Training up until this point took 111 hours and 24 minutes over 4940 steps. Other high RAM GPUs like the NVIDIA A100 (largest commercially accessible at 80 GB, $\sim$\$15000) are not yet widely available (in preview for select regions on Amazon Web Services at \$40.96/hour as a group of 8). This study is a promising step towards WSI-wise end-to-end deep learning with prevalent network architectures.