AgentMD: Empowering Language Agents for Risk Prediction with Large-Scale Clinical Tool Learning

Clinical calculators play a vital role in healthcare by offering accurate evidence-based predictions for various purposes such as prognosis. Nevertheless, their widespread utilization is frequently hindered by usability challenges, poor dissemination, and restricted functionality. Augmenting large language models with extensive collections of clinical calculators presents an opportunity to overcome these obstacles and improve workflow efficiency, but the scalability of the manual curation process poses a significant challenge. In response, we introduce AgentMD, a novel language agent capable of curating and applying clinical calculators across various clinical contexts. Using the published literature, AgentMD has automatically curated a collection of 2,164 diverse clinical calculators with executable functions and structured documentation, collectively named RiskCalcs. Manual evaluations show that RiskCalcs tools achieve an accuracy of over 80% on three quality metrics. At inference time, AgentMD can automatically select and apply the relevant RiskCalcs tools given any patient description. On the newly established RiskQA benchmark, AgentMD significantly outperforms chain-of-thought prompting with GPT-4 (87.7% vs. 40.9% in accuracy). Additionally, we also applied AgentMD to real-world clinical notes for analyzing both population-level and risk-level patient characteristics. In summary, our study illustrates the utility of language agents augmented with clinical calculators for healthcare analytics and patient care.

Integrating Large Language Models into the Debugging C Compiler for generating contextual error explanations

This paper introduces a method for Large Language Models (LLM) to produce enhanced compiler error explanations, in simple language, within our Debugging C Compiler (DCC). It is well documented that compiler error messages have been known to present a barrier for novices learning how to program. Although our initial use of DCC in introductory programming (CS1) has been instrumental in teaching C to novice programmers by providing safeguards to commonly occurring errors and translating the usually cryptic compiler error messages at both compile- and run-time, we proposed that incorporating LLM-generated explanations would further enhance the learning experience for novice programmers. Through an expert evaluation, we observed that LLM-generated explanations for compiler errors were conceptually accurate in 90% of compile-time errors, and 75% of run-time errors. Additionally, the new DCC-help tool has been increasingly adopted by students, with an average of 1047 unique runs per week, demonstrating a promising initial assessment of using LLMs to complement compiler output to enhance programming education for beginners. We release our tool as open-source to the community.

MotionInput v2.0 supporting DirectX: A modular library of open-source gesture-based machine learning and computer vision methods for interacting and controlling existing software with a webcam

Touchless computer interaction has become an important consideration during the COVID-19 pandemic period. Despite progress in machine learning and computer vision that allows for advanced gesture recognition, an integrated collection of such open-source methods and a user-customisable approach to utilising them in a low-cost solution for touchless interaction in existing software is still missing. In this paper, we introduce the MotionInput v2.0 application. This application utilises published open-source libraries and additional gesture definitions developed to take the video stream from a standard RGB webcam as input. It then maps human motion gestures to input operations for existing applications and games. The user can choose their own preferred way of interacting from a series of motion types, including single and bi-modal hand gesturing, full-body repetitive or extremities-based exercises, head and facial movements, eye tracking, and combinations of the above. We also introduce a series of bespoke gesture recognition classifications as DirectInput triggers, including gestures for idle states, auto calibration, depth capture from a 2D RGB webcam stream and tracking of facial motions such as mouth motions, winking, and head direction with rotation. Three use case areas assisted the development of the modules: creativity software, office and clinical software, and gaming software. A collection of open-source libraries has been integrated and provide a layer of modular gesture mapping on top of existing mouse and keyboard controls in Windows via DirectX. With ease of access to webcams integrated into most laptops and desktop computers, touchless computing becomes more available with MotionInput v2.0, in a federated and locally processed method.

Learning for Safety-Critical Control with Control Barrier Functions

Modern nonlinear control theory seeks to endow systems with properties of stability and safety, and have been deployed successfully in multiple domains. Despite this success, model uncertainty remains a significant challenge in synthesizing safe controllers, leading to degradation in the properties provided by the controllers. This paper develops a machine learning framework utilizing Control Barrier Functions (CBFs) to reduce model uncertainty as it impact the safe behavior of a system. This approach iteratively collects data and updates a controller, ultimately achieving safe behavior. We validate this method in simulation and experimentally on a Segway platform.